Results 231 to 240 of about 103,145 (303)

Metabolite‐sensitive cross‐bridge models of human atria reveal the impact of diabetes on muscle mechanoenergetics

The Journal of Physiology, EarlyView.
Abstract figure legend In this study, we used mathematical modelling to explore the effect of diabetes on muscle mechanoenergetics. Our parameterisation of cross‐bridge models using data from non‐diabetic and diabetic human atrial tissues revealed lower values for cross‐bridge stiffness, detachment rates, attachment rates and lower ATP sensitivity in ...
Julia H. Musgrave, June‐Chiew Han, Marie‐Louise Ward, Andrew J. Taberner, Kenneth Tran   +4 more
wiley   +1 more source

Blow-Out Cardiac Rupture Caused by Takotsubo Syndrome: An Autopsy Case Report. [PDF]

JACC Case Rep
Nagao T, Fujita S, Sakamoto A, Kataoka E, Kawakami R, Ohtani H, Mori H, Muto M, Maekawa Y.   +8 more
europepmc   +1 more source

Catecholaminergic polymorphic ventricular tachycardia–linked ryanodine receptor variants exhibit domain‐specific calcium leak and calmodulin affinity properties

The Journal of Physiology, EarlyView.
Abstract figure legend Catecholaminergic polymorphic ventricular tachycardia (CPVT) variants in N terminal (NTD) and central domain (CD) but not pore domain induce a pathological RyR2 conformational shift upon protein kinase A (PKA) phosphorylation, similar to that seen in heart failure (HF), calcium/calmodulin‐dependent protein kinase II (CaMKII ...
Hitoshi Uchinoumi, Xiaoqiong Dong, Ivanita Stefanon, Yi Yang, Eduardo Hertel Ribeiro, Bengt Svensson, Xander H. T. Wehrens, Takeshi Yamamoto, Razvan L. Cornea, Robyn T. Rebbeck, Masafumi Yano, Donald M. Bers   +11 more
wiley   +1 more source

The right kind of rarefaction: Coronary microvascular remodeling in right ventricle failure. [PDF]

JHLT Open
Vahdatpour C, Clapham K, Kawut SM, Jones K, Ryan JJ, Petty D, Talbot S, Dumoff K, Keeley EC, Lal P, Bryant AJ, Parker AM, Mazurek JA, Mirson L, Murphy A, Baird A, Schwietert M, Schurr A, Stein A, Hansen SM, Ou Z, Presson AP, Miller D.   +22 more
europepmc   +1 more source

A deep learning‐enabled toolkit for the 3D segmentation of ventricular cardiomyocytes

The Journal of Physiology, EarlyView.
Abstract figure legend 3D cardiomyocyte segmentation enables comprehensive analyses of myocardial microstructure in health and disease; however, it is technically demanding. We present an open‐source toolkit for this task, which reduces challenges associated with sample preparation, image restoration, segmentation and proofreading.
Joachim Greiner, Fabio Frangiamore, Frédéric Sonak, Josef Madl, Thomas Seidel, Peter Kohl, Eva A. Rog‐Zielinska   +6 more
wiley   +1 more source

M1 Macrophages Are a Source of IL-1α: A Driver of Progesterone Metabolism and Myometrial Contraction. [PDF]

Cells
Nadeem L, Librach M, Boros-Rausch A, Matthews B, Aguiar-Cabeza E, Shynlova O, Lye SJ.   +6 more
europepmc   +1 more source

14‐3‐3 proteins: Regulators of cardiac excitation–contraction coupling and stress responses

The Journal of Physiology, EarlyView.
Abstract figure legend 14‐3‐3 protein interactions in cardiac regulation. Schematic representation of 14‐3‐3 binding partners in excitation–contraction coupling, transcriptional regulation/development and stress response pathways. Asterisks indicate targets where the exact 14‐3‐3 binding site is unknown.
Heather C. Spooner, Rose E. Dixon
wiley   +1 more source

Targeting senescence to improve cardiac function following myocardial infarction. [PDF]

Trends Cardiovasc Med
Van Wagoner DR.
europepmc   +1 more source

Repolarization adaptation to rapid change in heart rate in human models – a review

The Journal of Physiology, EarlyView.
Abstract figure legend This review focuses on non‐invasive assessment of repolarization duration and dispersion (heterogeneity) adaptation to change in heart rate (HR). HR was increased incrementally by left atrial pacing during an electrophysiology (EP) study and by a bolus injection of atropine and in a step up/down fashion by repeated right atrial ...
Lennart Bergfeldt, Karl‐Jonas Axelsson, Pia Dahlberg, Farzad Vahedi, Gunilla Lundahl, Lennart Gransberg   +5 more
wiley   +1 more source

Tensile Forces and Nanofiber Alignment Influence Both Innervated and Non-Innervated Skeletal Myofiber Formation in Custom Mechanobioreactors. [PDF]

Biotechnol J
Hilman MC, Mourkioti F, Das S, Cullen DK.   +3 more
europepmc   +1 more source