Results 241 to 250 of about 103,145 (303)

Combined inhibition of atrial‐specific potassium currents as a possible anti‐arrhythmic drug therapy: A match made in silico

The Journal of Physiology, EarlyView.
Vladimír Sobota
wiley   +1 more source

Electromechanical modelling and simulation of human‐induced pluripotent stem cell‐derived cardiomyocytes predict drug‐induced contractility effects

The Journal of Physiology, EarlyView.
Abstract figure legend A study described in this paper describes a new tool for hiPSC‐CM electromechanical behaviour simulations using mathematical modelling. The model enables in silico assays making drug testing quick, comprehensive and accurate. New hiPSC‐CM models can be used as a platform to integrate in vitro and in silico findings.
Milda Folkmanaite, Xin Zhou, Andreas Koschinski, Wan‐Hua Hong, Marilù Casini, Manuel Koch, Ursula Ravens, Remi Peyronnet, Manuela Zaccolo, Blanca Rodriguez   +9 more
wiley   +1 more source

The effect of clinically relevant changes in extracellular electrolyte concentrations on human atrial arrhythmias. [PDF]

Commun Med (Lond)
Corrado C, Roney CH, Narayan SM, Giles WR, Niederer SA.   +4 more
europepmc   +1 more source

Structural determinants of re‐entrant drivers in atrial fibrillation: insights from digital twins derived from 3D micrometre‐resolution imaging of human heart

The Journal of Physiology, EarlyView.
Abstract figure legend Digital heart models of human donor atria with cardiac co‐morbidities revealed that regions with AWT variation, aligned myofibres adjacent to disorganised zones and fibrotic borders promoted the localisation and stability of RDs. AWT had a global influence, whereas fibre orientation and fibrosis exerted chamber‐specific regional ...
Anuradha Kulathilaka, Roshan Sharma, James Kennelly, Ning Li, Jieyun Bai, Bruce H. Smaill, Mark L. Trew, Vadim V. Fedorov, Jichao Zhao   +8 more
wiley   +1 more source

Fulminant Eosinophilic Myocarditis in a Young Adult: Successful Recovery After Extracorporeal Membrane Oxygenation (ECMO) Support and Multisystem Complications. [PDF]

Cureus
Leivaditis V, Ayed S, Schallmaier P, Windmüller V, Papatriantafyllou A, Kammerer I, Schumacher B, Dahm M.   +7 more
europepmc   +1 more source

Computational modelling of the pro‐ and antiarrhythmic effects of atrial high rate‐dependent trafficking of small‐conductance calcium‐activated potassium channels

The Journal of Physiology, EarlyView.
Abstract figure legend Small‐conductance calcium‐activated potassium (SK) channels are important for atrial repolarization and can be targeted for atrial‐specific antiarrhythmic treatments. We developed a computational model with a calcium sensor to study the effects of increased pacing rate (5 Hz), which enhances SK‐channel gating and forward ...
Stefan Meier, Dobromir Dobrev, Paul G. A. Volders, Jordi Heijman   +3 more
wiley   +1 more source

<i>Toxocara</i>-induced eosinophilic myocarditis. [PDF]

Proc (Bayl Univ Med Cent)
Wilson P, Gong T, Carlisle R, Wang H, Sandkovsky U.   +4 more
europepmc   +1 more source

Atrial fibrosis in atrial fibrillation: Mechanisms, mapping techniques and clinical applications

The Journal of Physiology, EarlyView.
Abstract figure legend Summary of key aspects of atrial fibrosis in atrial fibrillation, highlighting atrial fibrosis as a hallmark of atrial fibrillation (AF). (1) Different types of fibrosis (blue), illustrating reparative and reactive fibrosis; (2) fibrosis detection techniques (green), illustrating late gadolinium enhancement cardiac magnetic ...
Caterina Vidal Horrach, Laura Bevis, Cynthia Nwanna, Alexander M Zolotarev, Mahmoud Ehnesh, Semhar Biniam Misghina, Sayed Al‐Aidarous, Shohreh Honarbakhsh, Caroline H. Roney   +8 more
wiley   +1 more source

Therapeutic Impact of Vericiguat on Ventricular Remodeling in a Pressure-Overload Heart Failure Model. [PDF]

Life (Basel)
Hao WR, Chen CC, Li FA, Chen HY, Liu JC, Cheng TH, Chen JJ.   +6 more
europepmc   +1 more source

Single-cell transcriptomics reveal mechanisms of skeletal muscle differentiation across duck embryonic development. [PDF]

Commun Biol
Sun Y, Li Z, Jie Y, Yang N, Yin Z, Hou Z.   +5 more
europepmc   +1 more source