Results 251 to 260 of about 180,856 (396)

Use-dependent block of single sodium channels by lidocaine in guinea pig ventricular myocytes

, 1989
Thomas V. McDonald, Kenneth R. Courtney, William T. Clusin   +2 more
openalex   +1 more source

The addition of vericiguat to sacubitril/valsartan improved the composite endpoint. Add a finishing touch on heart failure medical therapy by vericiguat as secret ingredient

European Journal of Heart Failure, EarlyView.
Haruyuki Kinoshita, Hiroshi Sugino, Masashi Kodama, Misato Saito, Yoji Sumimoto, Kenji Masada, Takashi Shimonaga, Akiyo Suga, Mayumi Toko, Kaori Taniyasu, Saki Ushirozako, Yumiko Katayama, Chiemi Hirahara, Masahiro Takada   +13 more
wiley   +1 more source

The Effect of Anti‐3‐Hydroxy‐3‐Methylglutaryl‐CoA Reductase (HMGCR) Human Autoantibodies on Muscle Regeneration in Mice

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Anti‐3‐hydroxy‐3‐methylglutaryl‐CoA reductase (HMGCR) autoantibodies (aAbs) are pathogenic in immune‐mediated necrotizing myopathy (IMNM), partly through complement activation. C5 inhibition did not restore muscle strength in mice or patients with overt IMNM, suggesting additional pathogenic mechanisms.
Sarah Julien, Honorine Tomasevic, Thara Jaworski, Rachid Zoubairi, Jeremie Martinet, Laurent Drouot, Olivier Boyer   +6 more
wiley   +1 more source

Differential sensitivity of αo and αi to ADP-ribosylation by pertussis toxin in the intact cultured embryonic chick ventricular myocyte

, 1988
Bruce T. Liang, Jonas Galper
openalex   +1 more source

Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription coupling.

Journal of Clinical Investigation, 2006
Xu Wu, Tong Zhang, Julie Bossuyt, Xiaodong Li, T. McKinsey, J. Dedman, E. Olson, Ju Chen, J. Brown, D. Bers   +9 more
semanticscholar   +1 more source

Bone Health Following Lifestyle‐Induced Weight Loss in Individuals With Overweight/Obesity: A Narrative Review

Obesity, EarlyView.
ABSTRACT Although weight loss has many health benefits for people with overweight/obesity, its potential negative impact on bone health needs to be considered. This review provides a comprehensive overview of the effects of intentional weight loss achieved by lifestyle changes on bone health outcomes in adults with overweight/obesity and discusses ...
Mélanie A. Legrand, Julien Paccou, Jean‐Michel Lecerf, Thierry Thomas, Roland Chapurlat, Bernard Cortet, Emmanuel Biver, Maria Papageorgiou   +7 more
wiley   +1 more source

Role of human Myocyte Enhancer Factor 2 (MEF2) proteins in cancer: structural insights, functional diversity, and regulatory mechanisms. [PDF]

Cancer Cell Int
Khandelwal A, Fathi AH, Shetty S, Mukhopadhyay A, Devi V, Kabekkodu SP.   +5 more
europepmc   +1 more source

Cardiac myocyte necrosis induced by angiotensin II. [PDF]

, 1991
Lip Bun Tan, Jorge E. Jalil, R Pick, Joseph S. Janicki, K. T. Weber   +4 more
openalex   +1 more source

Importance of myocyte-nonmyocyte interactions in cardiac development and disease.

Circulation Research, 2012
Ying Tian, E. Morrisey
semanticscholar   +1 more source

Accelerating virtual patient generation with a Bayesian optimization and machine learning surrogate model

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 486-494, March 2025.
Abstract The pharmaceutical industry has increasingly adopted model‐informed drug discovery and development (MID3) to enhance productivity in drug discovery and development. Quantitative systems pharmacology (QSP), which integrates drug action mechanisms and disease complexities to predict clinical endpoints and biomarkers is central to MID3.
Hiroaki Iwata, Ryuta Saito
wiley   +1 more source