Results 91 to 100 of about 36,191 (258)

A case of canine urothelial carcinoma of the urinary bladder with skull and skeletal metastases

Australian Veterinary Journal, EarlyView.
Canine urinary bladder neoplasia is uncommon, representing less than 1% of canine neoplasms. Amongst cases of urinary bladder neoplasia in dogs, primary urothelial carcinoma is the most frequent. Urothelial carcinomas are malignant invasive tumours which tend to be slow growing and metastasise late.
A Teh, T Sima, E Shinozaki, R Malik
wiley   +1 more source

Tumor Necrosis Factor Alpha Inhibits L-Type Ca2+ Channels in Sensitized Guinea Pig Airway Smooth Muscle through ERK 1/2 Pathway

Mediators of Inflammation, 2016
Tumor necrosis factor alpha (TNF-α) is a potent proinflammatory cytokine that plays a significant role in the pathogenesis of asthma by inducing hyperresponsiveness and airway remodeling. TNF-α diminishes the L-type voltage dependent Ca2+ channel (L-VDCC)
Jorge Reyes-García, Edgar Flores-Soto, Héctor Solís-Chagoyán, Bettina Sommer, Verónica Díaz-Hernández, Luz María García-Hernández, Luis M. Montaño   +6 more
doaj   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Calcium handling by vascular myocytes in hypertension

Brazilian Journal of Medical and Biological Research, 1997
Calcium ions (Ca2+) trigger the contraction of vascular myocytes and the level of free intracellular Ca2+ within the myocyte is precisely regulated by sequestration and extrusion mechanisms. Extensive evidence indicates that a defect in the regulation of
R.C.A. Tostes, D.W. Wilde, L.M. Bendhack, R.C. Webb   +3 more
doaj   +1 more source

Coupling of alpha(1)-Adrenoceptors to ERK1/2 in the Human Prostate [PDF]

, 2011
Introduction: alpha(1)-Adrenoceptors are considered critical for the regulation of prostatic smooth muscle tone. However, previous studies suggested further alpha(1)-adrenoceptor functions besides contraction.
Goettinger, Johanna, Martin Hennenberg, Christian G. Stief, Petter Hedlund, Göttinger, Johanna,, Stief, Christian G., Christian Gratzke, Andersson, Karl-Erik, Reich, Oliver,, Reich, Oliver, Johanna Göttinger, Stief, Christian G.,, Schlenker, Boris,, Bauer, Ricarda M.,, Hedlund, Petter,, Andersson, Karl-Erik,, Strittmatter, Frank, Hennenberg, Martin,, Bauer, Ricarda M., Oliver Reich, Gratzke, Christian,, Ricarda M. Bauer, Hedlund, Petter, Frank Strittmatter, Karl-Erik Andersson, Gratzke, Christian, Hennenberg, Martin, Strittmatter, Frank,, Schlenker, Boris, Boris Schlenker   +29 more
core   +1 more source

Cardiotoxicity of BRAF/MEK inhibitors

British Journal of Pharmacology, EarlyView.
Abstract Rapidly accelerated fibrosarcoma type B/B‐Raf proto‐oncogene, serine/threonine kinase (BRAF) and mitogen‐activated protein kinase (MEK) inhibitors have transformed outcomes in cancer therapy, particularly in melanoma. However, cardiovascular toxicities are increasingly recognized in real‐world clinical practice.
Katharina Seuthe, Valerie Lohner, Kevin Terre, Thomas Riffelmacher, Roman Pfister   +4 more
wiley   +1 more source

Epicardial Lineages and Cardiac Repair

Journal of Developmental Biology, 2013
The death of cardiac myocytes resulting from myocardial infarction is a major cause of heart failure worldwide. Effective therapies for regenerating lost cardiac myocytes are lacking.
Manvendra K. Singh, Jonathan A. Epstein
doaj   +1 more source

Cyclic AMP-Dependent Regulation of Kv7 Voltage-Gated Potassium Channels

Frontiers in Physiology, 2020
Voltage-gated Kv7 potassium channels, encoded by KCNQ genes, have major physiological impacts cardiac myocytes, neurons, epithelial cells, and smooth muscle cells. Cyclic adenosine monophosphate (cAMP), a well-known intracellular secondary messenger, can
Jennifer van der Horst, Iain A. Greenwood, Thomas A. Jepps   +2 more
doaj   +1 more source

Aquaporin-1 expression in visceral smooth muscle cells of female rat reproductive tract

, 2000
The aquaporins (AQ-s) are a group of intrinsic membrane proteins which facilitate movement of water across cell membranes ; their recent identification in the kidney has led to the reappraisal of the mechanisms and pathways of water movement across ...
Verco, Christopher J., Carati, C. J., Gannon, B. J., Warnes, Graham Malcolm   +3 more
core   +1 more source

Diabetes is associated with impairment of uterine contractility and high Caesarean section rate [PDF]

, 2011
Aims/hypothesis The prevalence of births worldwide complicated by diabetes mellitus is increasing. In the UK, for example,
S. Al-Qahtani, S. Wray, Al-Qahtani, S., Dawood, F., A. Heath, Burdyga, T., T. Burdyga, Quenby, Siobhan, F. Dawood, S. Quenby, Wray, S., Heath, Andrew C., R. Floyd, Floyd, R.   +13 more
core   +1 more source