Results 91 to 100 of about 1,322,246 (257)
Endothelin and increased contractility in adult rat ventricular myocytes. Role of intracellular alkalosis induced by activation of the protein kinase C-dependent Na(+)-H+ exchanger [PDF]
, 1991 Endothelin, a 21-amino acid vasoactive peptide, is among the most potent positively inotropic agents yet described in mammalian heart. Having demonstrated that endothelin's inotropic effect is due, in part, to an apparent sensitization of cardiac ...
Smith, T. W. +2 more
core +1 more source
Calcium handling by vascular myocytes in hypertension
Brazilian Journal of Medical and Biological Research, 1997 Calcium ions (Ca2+) trigger the contraction of vascular myocytes and the level of free intracellular Ca2+ within the myocyte is precisely regulated by sequestration and extrusion mechanisms. Extensive evidence indicates that a defect in the regulation of
R.C.A. Tostes +3 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney +4 more
wiley +1 more source
Resident phenotypically modulated vascular smooth muscle cells in healthy human arteries. [PDF]
, 2012 Vascular interstitial cells (VICs) are non-contractile cells with filopodia previously described in healthy blood vessels of rodents and their function remains unknown.
Reddy, M +10 more
core +1 more source
Endothelial cell impact on smooth muscle cell properties: role of hemodynamic forces [PDF]
, 2009 The vascular endothelium is a dynamic cell monolayer located at the interface of the vessel wall and bloodstream, where it regulates the physiological effects of humoral and hemodynamic stimuli on vessel tone and remodelling.
Killeen, Maria T.
core +2 more sources
The Journal of Physiology, EarlyView.Abstract figure legend Schematic overview of the experimental and computational framework for investigating hiPSC‐CM electrophysiology with MEA systems. The MEA‐based model integrates experimental data with phenotype‐specific ionic models and tissue‐level heterogeneity.
Sofia Botti +2 more
wiley +1 more source
Epicardial Lineages and Cardiac Repair
Journal of Developmental Biology, 2013 The death of cardiac myocytes resulting from myocardial infarction is a major cause of heart failure worldwide. Effective therapies for regenerating lost cardiac myocytes are lacking.
Manvendra K. Singh, Jonathan A. Epstein
doaj +1 more source
Cyclic AMP-Dependent Regulation of Kv7 Voltage-Gated Potassium Channels
Frontiers in Physiology, 2020 Voltage-gated Kv7 potassium channels, encoded by KCNQ genes, have major physiological impacts cardiac myocytes, neurons, epithelial cells, and smooth muscle cells. Cyclic adenosine monophosphate (cAMP), a well-known intracellular secondary messenger, can
Jennifer van der Horst +2 more
doaj +1 more source
The Kv7 Channel and Cardiovascular Risk Factors
Frontiers in Cardiovascular Medicine, 2017 Potassium channels play a pivotal role in the regulation of excitability in cells such as neurons, cardiac myocytes, and vascular smooth muscle cells.
Andreas L. Fosmo, Øyvind B. Skraastad
doaj +1 more source
TMEM16A channel signalling microdomains in the regulation of vascular function
The Journal of Physiology, EarlyView.Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley +1 more source