Results 101 to 110 of about 35,109 (214)
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.5‐Fluorouracil (5‐FU) induces cardiovascular toxicity by increasing ROS, MDA, Bax, and caspase‐3 while decreasing antioxidant defenses and Bcl‐2 levels. Apigenin and selenium enhance antioxidant capacity, restore Bcl‐2 expression, suppress apoptosis, and rebalance redox status.
Gözde Atila Uslu +4 more
wiley +1 more source
SIRT Family: Biological Functions and Therapeutic Targets
MedComm, Volume 7, Issue 8, August 2026.SIRT1–SIRT7 networks from transgenic mice to human‑relevant therapeutic targets. SIRT1–SIRT7 form an isoform‑, organ‑, and disease‑specific regulatory network. Transgenic Sirt1–7 mouse models define central regulatory SIRTs (SIRT1, SIRT3, SIRT6), context‑dependent modifiers (SIRT2, SIRT4, SIRT5, SIRT7), and their key mechanisms and target organs. These
Jia‐Yi Wang +9 more
wiley +1 more source
Glucose Transporter 1 in Health and Disease
MedComm, Volume 7, Issue 8, August 2026.As the quintessential facilitator of basal glucose uptake, glucose transporter 1 (GLUT1) is indispensable for maintaining systemic energy homeostasis. This graphical abstract delineates the multidimensional landscape of GLUT1 in normal physiology. It highlights its tissue‐specific metabolic roles—from fueling erythrocytes and fetal development to ...
Yi Tai +3 more
wiley +1 more source
Coronary Microvascular Dysfunction: Epidemiology, Pathophysiology, Diagnosis, and Treatment
MedComm, Volume 7, Issue 8, August 2026.This visual summary illustrates the key aspects of coronary microvascular dysfunction (CMD) in angina with nonobstructive coronary artery disease (NOCAD), including epidemiology, pathophysiology (microvascular remodeling and endothelial dysfunction), the protective NRG‐1/ErbB signaling pathway, diagnostic methods, and both Western and traditional ...
Zhao Ge +8 more
wiley +1 more source
Macrophage: Biological Functions, Diseases, and Therapeutic Targets
MedComm, Volume 7, Issue 8, August 2026.Macrophages are sentinel innate immune cells that arise from embryonic precursors and bone marrow monocytes, displaying a functional continuum that transcends the classical M1 (pro‐inflammatory)/M2 (anti‐inflammatory) dichotomy. Under homeostatic conditions, balanced M1/M2 polarization preserves tissue integrity by coordinating immune surveillance ...
Bihang Sun +4 more
wiley +1 more source
A case of canine urothelial carcinoma of the urinary bladder with skull and skeletal metastases
Australian Veterinary Journal, Volume 104, Issue 8, Page 509-514, August 2026.Canine urinary bladder neoplasia is uncommon, representing less than 1% of canine neoplasms. Amongst cases of urinary bladder neoplasia in dogs, primary urothelial carcinoma is the most frequent. Urothelial carcinomas are malignant invasive tumours which tend to be slow growing and metastasise late.
A Teh, T Sima, E Shinozaki, R Malik
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Lysine l‐Lactylation: Bridging Metabolism, Chromatin and Disease
Cell Proliferation, Volume 59, Issue 8, August 2026.Enzymatic regulation of KL‐la. The enzymatic regulation of KL‐la involves two distinct pathways for L‐lactate accumulation: intracellular production through glycolysis‐derived pyruvate conversion by lactate dehydrogenase (LDH) or direct cellular uptake via monocarboxylate transporters (MCTs). These L‐lactate pools fuel two distinct lactylation pathways—
Anoosha Malik +10 more
wiley +1 more source
Experimental Physiology, Volume 111, Issue 8, Page 3514-3524, 1 August 2026.Abstract Left ventricular assist devices have gained traction both as a bridge therapy and as a destination therapy in the management of heart failure. Many of these devices reinstate blood flow in a continuous manner as opposed to the pulsatile flow present in normal physiology.
Tania Warnakulasuriya +2 more
wiley +1 more source
Protein kinase Cδ and pharmacomechanical coupling: Re‐envisioning cerebral vascular control
The Journal of Physiology, Volume 604, Issue 15, Page 6324-6347, 1 August 2026.Abstract figure legend Top, G‐protein coupled receptors trigger electromechanical and pharmacomechanical coupling, the latter via signal transduction pathways that inhibit myosin light chain phosphatase. Middle, the relative contribution of electromechanical and pharmacomechanical coupling varies with the concentration and the vessel area to which ...
Nadia Haghbin +10 more
wiley +1 more source
CaV1.2 dynamics in native male arterial myocytes
The Journal of Physiology, Volume 604, Issue 15, Page 6302-6323, 1 August 2026.Abstract figure legend Proposed model of microtubule‐dependent CaV1.2 reorganization in vascular disease. Schematic illustration of microtubule‐mediated delivery and stabilization of CaV1.2 channels into enlarged plasma membrane clusters in response to Ang II or hyperglycaemia, promoting cooperative gating and enhanced Ca2+ influx. Abstract L‐type CaV1.
Miguel Martin‐Aragon Baudel +9 more
wiley +1 more source