Results 131 to 140 of about 62,427 (259)

Na+-leak channel, non-selective (NALCN) regulates myometrial excitability and facilitates successful parturition [PDF]

, 2018
Background/Aims: Uterine contractility is controlled by electrical signals generated by myometrial smooth muscle cells. Because aberrant electrical signaling may cause inefficient uterine contractions and poor reproductive outcomes, there is great ...
Amazu, Chinwendu, Bok, Rachael, England, Sarah K., Hurt, K. Joseph, Ma, Xiaofeng, Reinl, Erin L., Wang, Yong, Wu, Wenjie, Zhao, Peinan   +8 more
core   +3 more sources

Uncertainty quantification via polynomial chaos expansion of myocardial fibre orientation and cardiac activation patterns

The Journal of Physiology, EarlyView.
Abstract figure legend Graphical representation of methods. We implemented three biventricular geometric models (Zenger et al., 2020) with rule‐based myocardial fibre orientations (Bayer et al., 2018). We evaluated variability in the fibre orientation via four sets of parameter distributions to determine the role of the primary and imbrication angles ...
Lindsay C. R. Tanner, Anna Busatto, Jake A. Bergquist, Wilson W. Good, Brian Zenger, Gernot Plank, Akil Narayan, Karli Gillette, Rob S. MacLeod   +8 more
wiley   +1 more source

The inwardly rectifying K+ channel KIR7.1 controls uterine excitability throughout pregnancy

EMBO Molecular Medicine, 2014
Abnormal uterine activity in pregnancy causes a range of important clinical disorders, including preterm birth, dysfunctional labour and post‐partum haemorrhage.
Conor McCloskey, Cara Rada, Elizabeth Bailey, Samantha McCavera, Hugo A van den Berg, Jolene Atia, David A Rand, Anatoly Shmygol, Yi‐Wah Chan, Siobhan Quenby, Jan J Brosens, Manu Vatish, Jie Zhang, Jerod S Denton, Michael J Taggart, Catherine Kettleborough, David Tickle, Jeff Jerman, Paul Wright, Timothy Dale, Srinivasan Kanumilli, Derek J Trezise, Steve Thornton, Pamela Brown, Roberto Catalano, Nan Lin, Sarah K England, Andrew M Blanks   +27 more
doaj   +1 more source

Changes in expression and activity of the secretory pathway Ca2+ATPase 1 (SPCA1) in A7r5 vascular smooth muscle cells cultured at different glucose concentrations [PDF]

, 2009
Diabetes mellitus-related vascular disease is often associated with both a dysregulation of Ca\(^{2+}\) homoeostasis and enhanced secretory activity in VSMCs (vascular smooth muscle cells).
Al-Bader, Aronson, Barbagallo, Byron, Curtis, Di Napoli, Dode, Dode, Fleischhacker, Francesco Michelangeli, Han, Hiromura, Kawada, Levy, Li, Mazzone, Missiaen, Mitchell, Ogunbayo, Owens, Pei Lai, Reinhardt, Shahbazi, Smogorzewski, Stalker, Teshima, Thyberg, Thyberg, Tong, Vanoevelen, Varadi, Wootton, Wootton, Wright, Yousif   +34 more
core   +6 more sources

Prediabetic cardiomyopathy is attenuated by hypothalamic PVN oxytocin neuron activation

The Journal of Physiology, EarlyView.
Abstract figure legend A long‐term high‐fat, high‐fructose diet induces prediabetes with insulin resistance, hyperinsulinaemia, elevated triglycerides and metabolic‐associated steatotic liver disease (MASLD) in male rats. Animals developed prediabetic cardiomyopathy characterized by diastolic dysfunction, interstitial fibrosis and tachycardia ...
Anna Nilsson, Joan Escobar, Kira Kuraoka, Ian Venter, Cielo A. Carnate, Matthew W. Kay, David Mendelowitz, Kathryn J. Schunke   +7 more
wiley   +1 more source

A deep learning‐enabled toolkit for the 3D segmentation of ventricular cardiomyocytes

The Journal of Physiology, EarlyView.
Abstract figure legend 3D cardiomyocyte segmentation enables comprehensive analyses of myocardial microstructure in health and disease; however, it is technically demanding. We present an open‐source toolkit for this task, which reduces challenges associated with sample preparation, image restoration, segmentation and proofreading.
Joachim Greiner, Fabio Frangiamore, Frédéric Sonak, Josef Madl, Thomas Seidel, Peter Kohl, Eva A. Rog‐Zielinska   +6 more
wiley   +1 more source

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source

Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model

The Journal of Physiology, EarlyView.
Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley   +1 more source

Potential health benefits of cold‐water immersion: the central role of PGC‐1α

The Journal of Physiology, EarlyView.
Abstract figure legend Cold‐water immersion (CWI) elicits autonomic, somato‐motoric (shivering thermogenesis), endocrine and metabolic, sensory transduction, and local biophysical effects that may converge on the transcriptional co‐activator PGC‐1α (centre).
Erich Hohenauer, Wafa Douzi, Johannes Burtscher   +2 more
wiley   +1 more source

Selective Gene Expression Analysis of Muscular and Vascular Components in Hearts Using Laser Microdissection Method

International Journal of Vascular Medicine, 2012
Background. The heart consists of various kinds of cell components. However, it has not been feasible to separately analyze the gene expression of individual components.
Ayami Ikeda, Hisashi Kai, Hidemi Kajimoto, Suguru Yasuoka, Masayoshi Kage, Tsutomu Imaizumi   +5 more
doaj   +1 more source