Results 151 to 160 of about 287,296 (284)

Structure mirroring function: What's the ‘matter’ with the funny current?

The Journal of Physiology, EarlyView.
Abstract figure legend The ‘funny’ (If) current of cardiac pacemaker cells has been first identified in the late 1970s as a major mechanism in the generation and control of cardiac pacemaking. Decades of studies have since described the properties of the funny current and of its molecular components, HCN channels, in the heart and brain, providing the ...
Andrea Saponaro, Dario DiFrancesco
wiley   +1 more source

In silico modelling of multi‐electrode arrays for enhancing cardiac drug testing on hiPSC‐CM heterogeneous tissues

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of the experimental and computational framework for investigating hiPSC‐CM electrophysiology with MEA systems. The MEA‐based model integrates experimental data with phenotype‐specific ionic models and tissue‐level heterogeneity.
Sofia Botti, Rolf Krause, Luca F. Pavarino   +2 more
wiley   +1 more source

Selective Gene Expression Analysis of Muscular and Vascular Components in Hearts Using Laser Microdissection Method

International Journal of Vascular Medicine, 2012
Background. The heart consists of various kinds of cell components. However, it has not been feasible to separately analyze the gene expression of individual components.
Ayami Ikeda, Hisashi Kai, Hidemi Kajimoto, Suguru Yasuoka, Masayoshi Kage, Tsutomu Imaizumi   +5 more
doaj   +1 more source

Models of cardiomyocyte–non‐myocyte electrical interactions

The Journal of Physiology, EarlyView.
Abstract figure legend Cardiomyocyte–non‐myocyte (CM–NM) electrotonic coupling. Left: conceptual contact‐based interactions between CM and other NM via connexin (Cx) proteins. Three basic scenarios are proposed: (i) ‘zero‐sided coupling’ where there are no electrical connections between CM and NM, (ii) ‘single‐sided coupling’ where NM are connected to ...
Ana Simon‐Chica, Axel Loewe, Peter Kohl   +2 more
wiley   +1 more source

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source

What's Your Diagnosis? Dog With a Laryngeal Mass

Veterinary Clinical Pathology, EarlyView.
Benjamin J. Haythornthwaite, Dylan Yaffy, Emma J. Holmes   +2 more
wiley   +1 more source

Rotating Frame Relaxation Time Mapping for the Visualization of the Sinoatrial Node Without Contrast Agent

NMR in Biomedicine, Volume 38, Issue 8, August 2025.
In this study, we have found that SAN structure displays higher relaxation time compared to remote myocardium. TRAFF2 and T1ρ are highly correlated with SAN size determined by histology. TRAFF2 and T1ρ relaxation time maps are feasible non‐invasive methods to visualize SAN structure.
Yi Li, Victor Casula, Tarja Huhta, Sarah Mailhiot, Katja Tolkkinen, Jouni Karjalainen, Timo Liimatainen   +6 more
wiley   +1 more source

Ultrafast Imaging of Physiological Brain Pulsations With Magnetic Resonance Encephalography—From Noise to Predictive Clinical Biomarker

NMR in Biomedicine, Volume 38, Issue 8, August 2025.
Human brain pulsations shown in this picture drive both blood and CSF flow. These pulsations can now be accurately detected with ultrafast MREG imaging. The ultrafast imaging offers early detection of abnormal brain pulsations that can precede tissue degeneration in Alzheimer's disease or predict mortality in brain lymphoma treatment. ABSTRACT Over the
Vesa Kiviniemi, Heta Helakari, Lauri Raitamaa, Niko Huotari, Zalan Rajna, Matti Järvelä, Ahmed Elabasy, Johanna Tuunanen, Valter Poltojainen, Tommi Väyrynen, Timo Tuovinen, Janne Kananen, Vesa Korhonen   +12 more
wiley   +1 more source

Pleiotropic Effects of the NSAID Fenamates on Chloride Channels: Opportunity for Ion Channelopathies?

Pharmacology Research &Perspectives, Volume 13, Issue 4, August 2025.
ABSTRACT Chloride channels are involved in many cellular processes, including cell volume regulation, modulation of cell excitability, and electrolyte and water secretion. Mutations of these proteins are associated with heterogeneous diseases such as myotonia, cystic fibrosis, epilepsy, deafness, lysosomal storage disease, and various kinds of renal ...
Paola Laghetti, Ilaria Saltarella, Simone Dell'Atti, Jean‐François Desaphy, Concetta Altamura   +4 more
wiley   +1 more source

Propranolol and Oxytocin‐Induced Contractility in Gravid Human Myometrium: An Ex Vivo Laboratory Study

BJOG: An International Journal of Obstetrics &Gynaecology, Volume 132, Issue 9, Page 1228-1237, August 2025.
ABSTRACT Objective To determine the effect of propranolol on myometrial contractions induced by low dose and high dose oxytocin. Design Prospective ex vivo laboratory study. Setting Mount Sinai Hospital, Toronto. Population Full‐term parturients who underwent elective caesarean deliveries (CD).
Mrinalini Balki, Lauren M. Miller, Jayalakshmi Caliaperumal, Stella Wang, Ella Huszti, John C. Kingdom   +5 more
wiley   +1 more source