Results 151 to 160 of about 62,427 (259)

Heat Therapy: Targeting Health, Disease, and Disability

Comprehensive Physiology, Volume 16, Issue 1, February 2026.
The predominance of evidence suggests heat therapy has an impact on all aspects of health and performance, but the drivers of that improvement, the extent to which they are improved, and the specific populations in which improvements manifest are far from completely understood.
Rauchelle E. Richey, Robert D. Hyldahl, Brendan W. Kaiser, Paige C. Geiger, John R. Halliwill, Christopher T. Minson   +5 more
wiley   +1 more source

BACH2 alleviates immune checkpoint inhibitors‐induced cardiac pyroptosis via transcriptionally promoting GRSF1

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
Immune checkpoint inhibitors cause elevated cardiac injuries in humans and mice. ICIs cause myocyte pyroptosis and cardiotoxicity, not via the adaptive immune system BACH2 ameliorates ICIs‐induced pyroptosis through transcriptionally promoting GRSF1. Lipoic acid, as a transcriptional inducer of BACH2, suppresses ICIs‐induced cardiotoxicity.
Mengying Cao, Zilong Liu, Di Zhao, Hongyuan Zhang, Xinjie He, Wenhao Wang, Xiaolin Wang, Cheng Yang, Pan Gao, Yunzeng Zou   +9 more
wiley   +1 more source

Multi‐Omics Revealed the Effects of Intrauterine Hyperglycemia Exposure on the Development of Skeletal Muscle in Offspring

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Gestational diabetes mellitus (GDM), a common pregnancy complication characterized by maternal hyperglycemia, negatively impacts offspring health. Skeletal muscle, a critical tissue for glucose and lipid metabolism, is especially vulnerable to prenatal environmental insults.
Rui Liu, Junsen She, Xinyuan Li, Yishang Yan, Jiaying Mo, Jianzhong Sheng, Hongbo Yang, Hefeng Huang   +7 more
wiley   +1 more source

Tissue‐Specific Extracellular Vesicles Enriched From Circulation: Exploring the Liquid Biopsy Perspective

Journal of Extracellular Biology, Volume 5, Issue 2, February 2026.
ABSTRACT Extracellular vesicles (EVs) released from tissues can be found in human biofluids. EVs reflect the phenotypic state of their cell of origin, carrying informative molecular biomarkers within and between tissues, and represent a promising target for liquid biopsy.
Biancamaria Pierri, Erez Eitan, Kenneth W. Witwer, Diane B. Re, Andrea A. Baccarelli, Haotian Wu   +5 more
wiley   +1 more source

The many dimeric faces of Lys49 PLA2‐like proteins: Conformational plasticity and membrane binding drive functional dimer states

Protein Science, Volume 35, Issue 2, February 2026.
Abstract Lys49 secreted phospholipase A2‐like proteins (sPLA2s) are major myotoxins in viperid snake venoms, causing rapid muscle damage in envenomation. Beyond their clinical relevance, these small non‐catalytic proteins provide a model to study how quaternary structure and conformational dynamics enable catalysis‐independent membrane disruption ...
Diane C. A. Lima, Vinicius Firmino dos Santos, Bernardo Rassi, Richard J. Ward, Thereza A. Soares   +4 more
wiley   +1 more source

Biochemical and Physiological Effects of Galanin in Health and Disease

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Galanin is a biologically active neuropeptide hormone that mediates its effects through three galanin receptors. Galanin signaling induces changes in glucose homeostasis amongst others and plays a dynamic role in the physiological health of many organ systems.
Patrick Mireles, Yubo Wang, Kathryn Rhodes, Sharon DeMorrow   +3 more
wiley   +1 more source

High voltage activated calcium channels [PDF]

, 1991
Biel, Martin, Bosse, Eva, Flockerzi, Veit, Hofmann, Franz, Hullin, Roger   +4 more
core   +1 more source

High Burden of Premature Ventricular Contractions Upregulates Transcriptional Markers of Inflammation and Promotes Adverse Cardiac Remodeling Linked to Cardiomyopathy. [PDF]

Circ Arrhythm Electrophysiol
Medina-Contreras JML, Balderas-Villalobos J, Gomez-Arroyo J, Hayles J, Kaszala K, Tan AY, Samsó M, Huizar JF, Eltit JM.   +8 more
europepmc   +1 more source

Effects of GLP-1 and GIP on cholinergic-induced contractility in isolated jejunal muscle from obese patients with and without type 2 diabetes mellitus. [PDF]

Front Physiol
Malinauskas M, Stukas D, Rysevaite-Kyguoliene K, Gudaityte R, Kupčinskas L, Casselbrant A, Jankauskaite L, Maleckas A.   +7 more
europepmc   +1 more source

Histological assessment of radiotherapy-induced injury in the anal canal: an exploratory study. [PDF]

Int J Colorectal Dis
Leventi A, Sibbons P, Tsigka A, Korkolis D, Peponi E, Skafida Ε, Moorghen M, Vaizey CJ, Glynne-Jones R, Maeda Y.   +9 more
europepmc   +1 more source