Results 11 to 20 of about 285,913 (271)

Arterial smooth muscle cell PKD2 (TRPP1) channels regulate systemic blood pressure

eLife, 2018
Systemic blood pressure is determined, in part, by arterial smooth muscle cells (myocytes). Several Transient Receptor Potential (TRP) channels are proposed to be expressed in arterial myocytes, but it is unclear if these proteins control physiological ...
Simon Bulley, Carlos Fernández-Peña, Raquibul Hasan, M Dennis Leo, Padmapriya Muralidharan, Charles E Mackay, Kirk W Evanson, Luiz Moreira-Junior, Alejandro Mata-Daboin, Sarah K Burris, Qian Wang, Korah P Kuruvilla, Jonathan H Jaggar   +12 more
doaj   +2 more sources

Calcium currents in isolated rabbit coronary arterial smooth muscle myocytes.

The Journal of Physiology, 1990
1. Calcium inward currents were recorded from relaxed enzymatically isolated smooth muscle cells from the rabbit epicardial left descending coronary artery using a single‐pipette voltage‐clamp technique. Outward K+ currents were blocked with CsCl‐tetraethylammonium‐filled pipette solutions. 2. Relaxed coronary smooth muscle cells had a maximum diameter
J J Matsuda, E. F. Shibata, K A Volk
openaire   +5 more sources

LIM-only protein, CRP2, switched on smooth muscle gene activity in adult cardiac myocytes [PDF]

Proceedings of the National Academy of Sciences, 2007
Smooth muscle α-actin gene activity appears in promyocardial cells well before cardiac myocyte differentiation and is down-regulated during the onset of rhythmic contractility and cardiac morphogenesis. The levels of LIM-only CRP2 correlated well with smooth muscle gene activity. Cardiomyocyte-specific expression of CRP2 in transgenic mice
Narasimhaswamy S. Belaguli, Jiang Chang, Robert J. Schwartz, David F. Chang   +3 more
openaire   +4 more sources

Functional and autoradiographic evidence for endothelin 1 receptors on human and rat cardiac myocytes. Comparison with single smooth muscle cells. [PDF]

Circulation Research, 1990
This study aimed to determine whether receptors for endothelin were present on the cardiac myocyte as well as on vascular smooth muscle cells. Low- and high-resolution autoradiography was performed using 125I-endothelin 1 on intact rat myocardium and samples of human ventricle obtained from explanted hearts at the time of transplant.
C J Moody, Magdi H. Yacoub, Sian E. Harding, M Chester, M R Dashwood, S. M. Jones, R M Sykes   +6 more
openaire   +4 more sources

Immunohistochemistry using an antibody to unphosphorylated connexin 43 to identify human myometrial interstitial cells [PDF]

Reproductive Biology and Endocrinology, 2008
Background Myometrial smooth myocytes contract as a result of electrical signalling via a process called excitation-contraction coupling. This process is understood in great detail at the cellular level but the generation and coordination of electrical ...
De Ridder, Dirk, Deprest, Jan, Gevaert, Thomas, Hutchings, Graham, Nilius, Bernd, Roskams, Tania, Van Lommel, Alfons   +6 more
core   +5 more sources

Cellular distribution of smooth muscle actins during mammalian embryogenesis: expression of the alpha-vascular but not the gamma-enteric isoform in differentiating striated myocytes. [PDF]

The Journal of cell biology, 1989
The cellular distribution of the alpha-vascular and gamma-enteric smooth muscle actin isoforms was analyzed in rat embryos from gestational day (gd) 8 through the first neonatal week by in situ antigen localization using isoactin specific monoclonal antibodies.
James L. Lessard, Nancy M. Sawtell
openaire   +3 more sources

Hypotension due to Kir6.1 gain‐of‐function in vascular smooth muscle [PDF]

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2013
BACKGROUND: K(ATP) channels, assembled from pore‐forming (Kir6.1 or Kir6.2) and regulatory (SUR1 or SUR2) subunits, link metabolism to excitability. Loss of Kir6.2 results in hypoglycemia and hyperinsulinemia, whereas loss of Kir6.1 causes Prinzmetal ...
Bernal-Mizrachi, Carlos, Blumer, Kendall J, Dietrich, Hans H, Harter, Theresa M, Knutsen, Russell H, Koster, Joseph C, Li, Anlong, Mecham, Robert P, Moreno-Dominguez, Alex, Nichols, Colin G, Osei-Owusu, Patrick, Remedi, Maria S, Uchida, Keita, Zhang, Haixia   +13 more
core   +3 more sources

TMEM16A channel upregulation in arterial smooth muscle cells produces vasoconstriction during diabetes.

American Journal of Physiology. Heart and Circulatory Physiology, 2021
The pathological involvement of anion channels in vascular dysfunction that occurs during type 2 diabetes (T2D) is unclear. Here, we tested the hypothesis that TMEM16A, a calcium (Ca2+)-activated chloride (Cl-) channel, contributes to modifications in ...
M. Leo, Dieniffer Peixoto-Nieves, Wen Yin, Somasundaram Raghavan, P. Muralidharan, Alejandro Mata-Daboin, J. Jaggar   +6 more
semanticscholar   +1 more source

Defining cardiac cell populations and relative cellular composition of the early fetal human heart

PLoS ONE, 2022
While the adult human heart is primarily composed of cardiomyocytes, fibroblasts, endothelial and smooth muscle cells, the cellular composition during early development remains largely unknown.
Jennifer M. Dewing, Vinay Saunders, Ita O’Kelly, David I. Wilson   +3 more
doaj   +2 more sources

MALAT1: A Pivotal lncRNA in the Phenotypic Switch of Gastric Smooth Muscle Cells via the Targeting of the miR-449a/DLL1 Axis in Diabetic Gastroparesis

Frontiers in Pharmacology, 2021
Diabetic gastroparesis (DGP) is a common complication of diabetes mellitus (DM). Our previous study suggested that the expression of the long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is closely related to ...
Yanjuan Wang, Yan Wang, Boqian Zhu, Ying Zhu, Ya Jiang, Wenjie Xiong, Lin Lin, Yaoyao Gong   +7 more
doaj   +1 more source