Results 11 to 20 of about 34,087 (176)

Arterial smooth muscle cell PKD2 (TRPP1) channels regulate systemic blood pressure

eLife, 2018
Systemic blood pressure is determined, in part, by arterial smooth muscle cells (myocytes). Several Transient Receptor Potential (TRP) channels are proposed to be expressed in arterial myocytes, but it is unclear if these proteins control physiological ...
Simon Bulley, Carlos Fernández-Peña, Raquibul Hasan, M Dennis Leo, Padmapriya Muralidharan, Charles E Mackay, Kirk W Evanson, Luiz Moreira-Junior, Alejandro Mata-Daboin, Sarah K Burris, Qian Wang, Korah P Kuruvilla, Jonathan H Jaggar   +12 more
doaj   +1 more source

Proliferative Role of Kv11 Channels in Murine Arteries

Frontiers in Physiology, 2017
K+ channels encoded by the ether-a-go-go related gene (ERG1 or KCNH2) are important determinants of the cardiac action potential. Expression of both cardiac isoforms (ERG1a and ERG1b) were identified in murine portal vein and distinctive voltage-gated K+
Vincenzo Barrese, Pilar Cidad, Shuk Y. Yeung, Jose R. López-López, Alister J. McNeish, Susumu Ohya, Maria T. Pérez-García, Iain A. Greenwood   +7 more
doaj   +1 more source

Immunohistochemistry using an antibody to unphosphorylated connexin 43 to identify human myometrial interstitial cells

Reproductive Biology and Endocrinology, 2008
Background Myometrial smooth myocytes contract as a result of electrical signalling via a process called excitation-contraction coupling. This process is understood in great detail at the cellular level but the generation and coordination of electrical ...
Van Lommel Alfons, Roskams Tania, Deprest Jan, Gevaert Thomas, Hutchings Graham, Nilius Bernd, De Ridder Dirk   +6 more
doaj   +1 more source

The use of calcium channel blockers in the treatment of cardiovascular diseases [PDF]

Arhiv za farmaciju, 2015
Voltage-sensitive calcium channels (L-type) mediate the entry of extracellular calcium into smooth muscle and cardiac myocytes and sinoatrial and atrioventricular nodal cells in response to electrical depolarization.
Đokić Mirjana
doaj   +1 more source

Characterization of Muscarinic Receptor-Mediated Cationic Currents in Longitudinal Smooth Muscle Cells of Mouse Small Intestine

Journal of Pharmacological Sciences, 2006
.: In mouse intestinal smooth muscle cells held at −50 mV, carbachol evoked an atropine-sensitive inward current in the intracellular presence of Cs+.
Takashi Sakamoto, Toshihiro Unno, Hayato Matsuyama, Mai Uchiyama, Mitsunobu Hattori, Masakazu Nishimura, Seiichi Komori   +6 more
doaj   +1 more source

The Selective Rat Toxicant Norbormide Blocks KATP Channels in Smooth Muscle Cells But Not in Insulin-Secreting Cells

Frontiers in Pharmacology, 2019
Norbormide is a toxicant selective for rats to which it induces a widespread vasoconstriction. In a recent paper, we hypothesized a role of ATP-sensitive potassium (KATP) channels in norbormide-induced vasoconstriction.
Simona Saponara, Fabio Fusi, Ottavia Spiga, Alfonso Trezza, Brian Hopkins, Brian Hopkins, Margaret A. Brimble, David Rennison, Sergio Bova   +8 more
doaj   +1 more source

Sources and regulation of nitric oxide synthesis in uterus smooth muscle cells [PDF]

The Ukrainian Biochemical Journal, 2019
It was proved that NO synthesis in isolated mitochondria of rat uterus smooth muscle depended on the entry of exogenous Ca2+ to mitochondria (inhibited by 1-10 mM Mg2+ in the absence of ATP and by 10 μM ruthenium red) and was suppressed by calmodulin ...
H. V. Danylovych , Yu. V. Danylovych, T. V. Bohach, S. O. Kosterin, S. O. Kosterin   +4 more
doaj   +1 more source

Myocardial repair with long-term and low-dose administration of a nitric oxide synthesis inhibitor. Myofibroblasts, type III collagen and fibronectin

Arquivos Brasileiros de Cardiologia, 1999
OBJECTIVE: To study the healing process of the myocardium in hypertensive rats undergoing inhibition of nitric oxide synthesis. METHODS: Two groups of animals were studied: one received L-NAME, 12mg/kg/day, and the other was a control group. The presence
Mônica Gomes Pessanha, Myriam Dumas Hahn, Carlos Alberto Mandarim-de-Lacerda   +2 more
doaj   +1 more source

Heteromeric Channels Formed From Alternating Kv7.4 and Kv7.5 α-Subunits Display Biophysical, Regulatory, and Pharmacological Characteristics of Smooth Muscle M-Currents

Frontiers in Physiology, 2020
Smooth muscle cells of the vasculature, viscera, and lungs generally express multiple α-subunits of the Kv7 voltage-gated potassium channel family, with increasing evidence that both Kv7.4 and Kv7.5 can conduct “M-currents” that are functionally ...
Lyubov I. Brueggemann, Leanne L. Cribbs, Kenneth L. Byron   +2 more
doaj   +1 more source

Piezo1 in Smooth Muscle Cells Is Involved in Hypertension-Dependent Arterial Remodeling

Cell Reports, 2015
The mechanically activated non-selective cation channel Piezo1 is a determinant of vascular architecture during early development. Piezo1-deficient embryos die at midgestation with disorganized blood vessels.
Kevin Retailleau, Fabrice Duprat, Malika Arhatte, Sanjeev Sumant Ranade, Rémi Peyronnet, Joana Raquel Martins, Martine Jodar, Céline Moro, Stefan Offermanns, Yuanyi Feng, Sophie Demolombe, Amanda Patel, Eric Honoré   +12 more
doaj   +1 more source