Results 11 to 20 of about 34,551 (223)

6-Nitrodopamine Potentiates Catecholamine-Induced Ca²⁺ _i Release in Human Aortic Smooth Muscle and Modulates Vascular Smooth Muscle Contractility. [PDF]

Basic Clin Pharmacol Toxicol
ABSTRACT Background In vascular smooth muscle, rises in intracellular calcium [Ca2+]i drive contraction downstream of α1‐adrenoceptor activation via IP3. Endothelium‐derived 6‐nitrodopamine (6‐ND) augments cardiac catecholamine actions; however, its effect on [Ca2+]i is unknown.
Britto-Júnior J, Lima AT, Qiao S, Tang HF, Cardenas V, Antunes E, De Nucci G, Ferro A.   +7 more
europepmc   +2 more sources

Myocardin Reverses Hypoxia-Inducible Factor-1α Mediated Phenotypic Modulation of Corpus Cavernosum Smooth Muscle Cells in Hypoxia Induced by Cobalt Chloride

The World Journal of Men's Health, 2023
Purpose: We aimed to investigate the mechanism of phenotypic transformation of corporal cavernosum smooth muscle cells (CCSMCs) under hypoxic conditions in vitro.
Xiongcai Zhou, Chao Luo, Junhong Fan, Guangqian Gao, Tao Wang, Haibo Zhang, Anyang Wei   +6 more
doaj   +1 more source

Differentiation of patient-specific void urine-derived human induced pluripotent stem cells to fibroblasts and skeletal muscle myocytes

Scientific Reports, 2023
Cell-based therapy is a major focus for treatment of stress urinary incontinence (SUI). However, derivation of primary cells requires tissue biopsies, which often have adverse effects on patients. A recent study used human induced pluripotent stem cells (
M. Kibschull, T. T. N. Nguyen, T. Chow, M. Alarab, S. J. Lye, I. Rogers, O. Shynlova   +6 more
doaj   +1 more source

The Role of Mechanotransduction on Vascular Smooth Muscle Myocytes Cytoskeleton and Contractile Function [PDF]

The Anatomical Record, 2014
ABSTRACTSmooth muscle (SM) exhibits a highly organized structural hierarchy that extends over multiple spatial scales to perform a wide range of functions at the cellular, tissue, and organ levels. Early efforts primarily focused on understanding vascular SM (VSM) function through biochemical signaling.
George J C, Ye, Alexander P, Nesmith, Kevin Kit, Parker   +2 more
openaire   +2 more sources

Mitochondrial Modulation Of Spontaneous Ca2+ Oscillations In Portal Vein Smooth Muscle Myocytes [PDF]

Biophysical Journal, 2009
Transient increases in cytosolic Ca2+ concentration ([Ca2+]c) regulate many smooth muscle activities including contraction, transcription, growth and apoptosis. The onset of some processes involve sarcoplasmic reticulum Ca2+ release triggered by either inositol 1,4,5-trisphosphate (InsP3) or occurring spontaneously. Mitochondrial Ca2+ uptake influences
Olson, Marnie L., Chalmers, Susan, Avlonitis, Nicolaos, Stanton-Humphreys, Megan N., Conway, Stuart J., McCarron, John G.   +5 more
openaire   +1 more source

Arterial smooth muscle cell PKD2 (TRPP1) channels regulate systemic blood pressure

eLife, 2018
Systemic blood pressure is determined, in part, by arterial smooth muscle cells (myocytes). Several Transient Receptor Potential (TRP) channels are proposed to be expressed in arterial myocytes, but it is unclear if these proteins control physiological ...
Simon Bulley, Carlos Fernández-Peña, Raquibul Hasan, M Dennis Leo, Padmapriya Muralidharan, Charles E Mackay, Kirk W Evanson, Luiz Moreira-Junior, Alejandro Mata-Daboin, Sarah K Burris, Qian Wang, Korah P Kuruvilla, Jonathan H Jaggar   +12 more
doaj   +1 more source

LIM-only protein, CRP2, switched on smooth muscle gene activity in adult cardiac myocytes [PDF]

Proceedings of the National Academy of Sciences, 2007
Smooth muscle α-actin gene activity appears in promyocardial cells well before cardiac myocyte differentiation and is down-regulated during the onset of rhythmic contractility and cardiac morphogenesis. The levels of LIM-only CRP2 correlated well with smooth muscle gene activity. Cardiomyocyte-specific expression of CRP2 in transgenic mice
David F, Chang, Narasimhaswamy S, Belaguli, Jiang, Chang, Robert J, Schwartz   +3 more
openaire   +2 more sources

Proliferative Role of Kv11 Channels in Murine Arteries

Frontiers in Physiology, 2017
K+ channels encoded by the ether-a-go-go related gene (ERG1 or KCNH2) are important determinants of the cardiac action potential. Expression of both cardiac isoforms (ERG1a and ERG1b) were identified in murine portal vein and distinctive voltage-gated K+
Vincenzo Barrese, Pilar Cidad, Shuk Y. Yeung, Jose R. López-López, Alister J. McNeish, Susumu Ohya, Maria T. Pérez-García, Iain A. Greenwood   +7 more
doaj   +1 more source

Immunohistochemistry using an antibody to unphosphorylated connexin 43 to identify human myometrial interstitial cells

Reproductive Biology and Endocrinology, 2008
Background Myometrial smooth myocytes contract as a result of electrical signalling via a process called excitation-contraction coupling. This process is understood in great detail at the cellular level but the generation and coordination of electrical ...
Van Lommel Alfons, Roskams Tania, Deprest Jan, Gevaert Thomas, Hutchings Graham, Nilius Bernd, De Ridder Dirk   +6 more
doaj   +1 more source

Characterization of Muscarinic Receptor-Mediated Cationic Currents in Longitudinal Smooth Muscle Cells of Mouse Small Intestine

Journal of Pharmacological Sciences, 2006
.: In mouse intestinal smooth muscle cells held at −50 mV, carbachol evoked an atropine-sensitive inward current in the intracellular presence of Cs+.
Takashi Sakamoto, Toshihiro Unno, Hayato Matsuyama, Mai Uchiyama, Mitsunobu Hattori, Masakazu Nishimura, Seiichi Komori   +6 more
doaj   +1 more source