Results 21 to 30 of about 36,191 (258)

Characterization of Muscarinic Receptor-Mediated Cationic Currents in Longitudinal Smooth Muscle Cells of Mouse Small Intestine

open access: yesJournal of Pharmacological Sciences, 2006
.: In mouse intestinal smooth muscle cells held at −50 mV, carbachol evoked an atropine-sensitive inward current in the intracellular presence of Cs+.
Takashi Sakamoto   +6 more
doaj   +1 more source

The use of calcium channel blockers in the treatment of cardiovascular diseases [PDF]

open access: yesArhiv za farmaciju, 2015
Voltage-sensitive calcium channels (L-type) mediate the entry of extracellular calcium into smooth muscle and cardiac myocytes and sinoatrial and atrioventricular nodal cells in response to electrical depolarization.
Đokić Mirjana
doaj   +1 more source

LIM-only protein, CRP2, switched on smooth muscle gene activity in adult cardiac myocytes [PDF]

open access: yesProceedings of the National Academy of Sciences, 2007
Smooth muscle α-actin gene activity appears in promyocardial cells well before cardiac myocyte differentiation and is down-regulated during the onset of rhythmic contractility and cardiac morphogenesis. The levels of LIM-only CRP2 correlated well with smooth muscle gene activity. Cardiomyocyte-specific expression of CRP2 in transgenic mice
David F, Chang   +3 more
openaire   +2 more sources

The Selective Rat Toxicant Norbormide Blocks KATP Channels in Smooth Muscle Cells But Not in Insulin-Secreting Cells

open access: yesFrontiers in Pharmacology, 2019
Norbormide is a toxicant selective for rats to which it induces a widespread vasoconstriction. In a recent paper, we hypothesized a role of ATP-sensitive potassium (KATP) channels in norbormide-induced vasoconstriction.
Simona Saponara   +8 more
doaj   +1 more source

Sources and regulation of nitric oxide synthesis in uterus smooth muscle cells [PDF]

open access: yesThe Ukrainian Biochemical Journal, 2019
It was proved that NO synthesis in isolated mitochondria of rat uterus smooth muscle depended on the entry of exogenous Ca2+ to mitochondria (inhibited by 1-10 mM Mg2+ in the absence of ATP and by 10 μM ruthenium red) and was suppressed by calmodulin ...
H. V. Danylovych   +4 more
doaj   +1 more source

Endothelins. Myocardial actions of a new class of cytokines [PDF]

open access: yes, 1992
There is growing evidence to support the existence of a dynamic interaction in vivo between cardiac myocytes and adjacent microvascular endothelial cells in the regulation of both cardiac myocyte and possibly endothelial cell phenotype and function ...
Smith, T. W.   +3 more
core   +1 more source

Nitric oxide mediates stretch-induced Ca2+ release via activation of phosphatidylinositol 3-kinase-Akt pathway in smooth muscle.

open access: yesPLoS ONE, 2008
BackgroundHollow smooth muscle organs such as the bladder undergo significant changes in wall tension associated with filling and distension, with attendant changes in muscle tone.
Bin Wei   +9 more
doaj   +1 more source

Myocardial repair with long-term and low-dose administration of a nitric oxide synthesis inhibitor. Myofibroblasts, type III collagen and fibronectin

open access: yesArquivos Brasileiros de Cardiologia, 1999
OBJECTIVE: To study the healing process of the myocardium in hypertensive rats undergoing inhibition of nitric oxide synthesis. METHODS: Two groups of animals were studied: one received L-NAME, 12mg/kg/day, and the other was a control group. The presence
Mônica Gomes Pessanha   +2 more
doaj   +1 more source

Calix[4]arene C-99 inhibits myosin ATPase activity and changes the organization of contractile filaments of myometrium [PDF]

open access: yesThe Ukrainian Biochemical Journal, 2015
Calix[4]arenes are cup-like macrocyclic (polyphenolic) compounds, they are regarded as promising molecular “platforms” for the design of new physiologically active compounds.
R. D. Labyntseva,   +5 more
doaj   +1 more source

Heteromeric Channels Formed From Alternating Kv7.4 and Kv7.5 α-Subunits Display Biophysical, Regulatory, and Pharmacological Characteristics of Smooth Muscle M-Currents

open access: yesFrontiers in Physiology, 2020
Smooth muscle cells of the vasculature, viscera, and lungs generally express multiple α-subunits of the Kv7 voltage-gated potassium channel family, with increasing evidence that both Kv7.4 and Kv7.5 can conduct “M-currents” that are functionally ...
Lyubov I. Brueggemann   +2 more
doaj   +1 more source

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