Results 11 to 20 of about 36,191 (258)

The inwardly rectifying K+ channel KIR7.1 controls uterine excitability throughout pregnancy [PDF]

EMBO Molecular Medicine, 2014
Abnormal uterine activity in pregnancy causes a range of important clinical disorders, including preterm birth, dysfunctional labour and post‐partum haemorrhage.
Conor McCloskey, Cara Rada, Elizabeth Bailey, Samantha McCavera, Hugo A van den Berg, Jolene Atia, David A Rand, Anatoly Shmygol, Yi‐Wah Chan, Siobhan Quenby, Jan J Brosens, Manu Vatish, Jie Zhang, Jerod S Denton, Michael J Taggart, Catherine Kettleborough, David Tickle, Jeff Jerman, Paul Wright, Timothy Dale, Srinivasan Kanumilli, Derek J Trezise, Steve Thornton, Pamela Brown, Roberto Catalano, Nan Lin, Sarah K England, Andrew M Blanks   +27 more
doaj   +2 more sources

Myocardin Reverses Hypoxia-Inducible Factor-1α Mediated Phenotypic Modulation of Corpus Cavernosum Smooth Muscle Cells in Hypoxia Induced by Cobalt Chloride

The World Journal of Men's Health, 2023
Purpose: We aimed to investigate the mechanism of phenotypic transformation of corporal cavernosum smooth muscle cells (CCSMCs) under hypoxic conditions in vitro.
Xiongcai Zhou, Chao Luo, Junhong Fan, Guangqian Gao, Tao Wang, Haibo Zhang, Anyang Wei   +6 more
doaj   +1 more source

Differentiation of patient-specific void urine-derived human induced pluripotent stem cells to fibroblasts and skeletal muscle myocytes

Scientific Reports, 2023
Cell-based therapy is a major focus for treatment of stress urinary incontinence (SUI). However, derivation of primary cells requires tissue biopsies, which often have adverse effects on patients. A recent study used human induced pluripotent stem cells (
M. Kibschull, T. T. N. Nguyen, T. Chow, M. Alarab, S. J. Lye, I. Rogers, O. Shynlova   +6 more
doaj   +1 more source

Arterial smooth muscle cell PKD2 (TRPP1) channels regulate systemic blood pressure

eLife, 2018
Systemic blood pressure is determined, in part, by arterial smooth muscle cells (myocytes). Several Transient Receptor Potential (TRP) channels are proposed to be expressed in arterial myocytes, but it is unclear if these proteins control physiological ...
Simon Bulley, Carlos Fernández-Peña, Raquibul Hasan, M Dennis Leo, Padmapriya Muralidharan, Charles E Mackay, Kirk W Evanson, Luiz Moreira-Junior, Alejandro Mata-Daboin, Sarah K Burris, Qian Wang, Korah P Kuruvilla, Jonathan H Jaggar   +12 more
doaj   +1 more source

Effects of 17β-oestradiol on rat detrusor smooth muscle contractility [PDF]

, 2009
The aim of this study was to investigate the effect of 17β-oestradiol (E2) on detrusor smooth muscle contractility and its possible neuroprotective role against ischaemic-like condition, which could arise during overactive bladder disease.
Keith L. Brain, Sgaragli, G, Giampietro Sgaragli, Pessina, F, Sgaragli, G., Pessina, F., Young, John, John S. Young, Valeri, A., Young, JS, Sgaragli, GIAN PIETRO, Valeri, A, Young, J. S., Aurora Valeri, Brain, K., Brain, K. L., Pessina, Federica, Federica Pessina, Brain, Keith; id_orcid   +18 more
core   +1 more source

Proliferative Role of Kv11 Channels in Murine Arteries

Frontiers in Physiology, 2017
K+ channels encoded by the ether-a-go-go related gene (ERG1 or KCNH2) are important determinants of the cardiac action potential. Expression of both cardiac isoforms (ERG1a and ERG1b) were identified in murine portal vein and distinctive voltage-gated K+
Vincenzo Barrese, Pilar Cidad, Shuk Y. Yeung, Jose R. López-López, Alister J. McNeish, Susumu Ohya, Maria T. Pérez-García, Iain A. Greenwood   +7 more
doaj   +1 more source

Divergent differentiation paths in airway smooth muscle culture: induction of functionally contractile myocytes [PDF]

American Journal of Physiology-Lung Cellular and Molecular Physiology, 1999
We tested the hypothesis that prolonged serum deprivation would allow a subset of cultured airway myocytes to reacquire the abundant contractile protein content, marked shortening capacity, and elongated morphology characteristic of contractile cells within intact tissue. Passage 1 or 2 canine tracheal smooth muscle (SM) cells were grown to confluence,
A J, Halayko, B, Camoretti-Mercado, S M, Forsythe, J E, Vieira, R W, Mitchell, M E, Wylam, M B, Hershenson, J, Solway   +7 more
openaire   +2 more sources

Mitochondrial Modulation Of Spontaneous Ca2+ Oscillations In Portal Vein Smooth Muscle Myocytes [PDF]

Biophysical Journal, 2009
Transient increases in cytosolic Ca2+ concentration ([Ca2+]c) regulate many smooth muscle activities including contraction, transcription, growth and apoptosis. The onset of some processes involve sarcoplasmic reticulum Ca2+ release triggered by either inositol 1,4,5-trisphosphate (InsP3) or occurring spontaneously. Mitochondrial Ca2+ uptake influences
Olson, Marnie L., Chalmers, Susan, Avlonitis, Nicolaos, Stanton-Humphreys, Megan N., Conway, Stuart J., McCarron, John G.   +5 more
openaire   +1 more source

Immunohistochemistry using an antibody to unphosphorylated connexin 43 to identify human myometrial interstitial cells

Reproductive Biology and Endocrinology, 2008
Background Myometrial smooth myocytes contract as a result of electrical signalling via a process called excitation-contraction coupling. This process is understood in great detail at the cellular level but the generation and coordination of electrical ...
Van Lommel Alfons, Roskams Tania, Deprest Jan, Gevaert Thomas, Hutchings Graham, Nilius Bernd, De Ridder Dirk   +6 more
doaj   +1 more source

Mechanisms altering airway smooth muscle cell Ca(2+) homeostasis in two asthma models [PDF]

, 2008
Background: Asthma is characterized by airway remodeling, altered mucus production and airway smooth muscle cell (ASMC) contraction causing extensive airway narrowing. In particular, alterations of ASMC contractility seem to be of crucial importance. The
Kellner, Julia, Tantzscher, Juliane, Edelmann, Martin, Bergner, Albrecht, Oelmez, Hamza, Huber, Rudolf M., Fischer, Rainald   +6 more
core   +1 more source