Inflammation and RegenerationCa2+ signals play a crucial role in maintaining cardiovascular homeostasis, including regulation of the heartbeat, blood pressure, and adaptation to changes in the external environment.
Tsukasa Koide +5 more
doaj +4 more sources
cGMP signals in smooth muscle cells and cardiac myocytes [PDF]
BMC Pharmacology, 2011 Background cGMP plays an important role in the cardiovascular system and is involved in smooth muscle relaxation and inhibition of platelet aggregation. cGMP concentrations inside cells are determined by an interplay of cGMP synthesis through natriuretic peptide or NO receptor guanylyl cyclases on the one hand and cGMP-degrading phosphodiesterases on ...
Krawutschke, Christian +2 more
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Smooth Muscle Cells, But Not Myocytes, of Host Origin in Transplanted Human Hearts [PDF]
Circulation, 2002 Background — There is increasing evidence to support a role for stem cells in the regeneration and repair of the human cardiovascular system.
Ruchira, Glaser +3 more
openaire +2 more sources
The Role of Mechanotransduction on Vascular Smooth Muscle Myocytes Cytoskeleton and Contractile Function [PDF]
The Anatomical Record, 2014 ABSTRACTSmooth muscle (SM) exhibits a highly organized structural hierarchy that extends over multiple spatial scales to perform a wide range of functions at the cellular, tissue, and organ levels. Early efforts primarily focused on understanding vascular SM (VSM) function through biochemical signaling.
George J C, Ye +2 more
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Divergent differentiation paths in airway smooth muscle culture: induction of functionally contractile myocytes [PDF]
American Journal of Physiology-Lung Cellular and Molecular Physiology, 1999 We tested the hypothesis that prolonged serum deprivation would allow a subset of cultured airway myocytes to reacquire the abundant contractile protein content, marked shortening capacity, and elongated morphology characteristic of contractile cells within intact tissue. Passage 1 or 2 canine tracheal smooth muscle (SM) cells were grown to confluence,
A J, Halayko +7 more
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Endothelin-Induced Sarcoplasmic Reticulum Calcium Depletion Waves in Vascular Smooth Muscle Cells [PDF]
, 2011 Agonist-stimulated waves of elevated cytoplasmic Ca2+ concentration ([Ca2+]i ) regulate blood vessel tone and vasomotion in vascular smooth muscle. Previous studies employing cytoplasmic Ca2+ indicators revealed that these Ca2+ waves were generated by a ...
Cornelis van Breemen +7 more
core +1 more source
An investigation of NAADP-dependent Ca²⁺ signalling mechanisms in arterial smooth muscle [PDF]
, 2007 Previous investigations on pulmonary artery smooth muscle cells have shown that nicotinic acid adenine dinucleotide diphosphate (NAADP) evokes highly localised intracellular Ca²⁺ bursts by mobilising thapsigargin-insensitive Ca²⁺ stores.
Kinnear, Nicholas P.
core +2 more sources
Protein changes associated with embryonic stem cell differentiation to vascular smooth muscle cells [PDF]
, 2006 PhDEmbryonic stem (ES) cells can differentiate into many different cell lines, including vascular smooth muscle cells (SMCs). The aim of this project is to characterize protein changes during this differentiation process.
Yin, Xiaoke
core +4 more sources
Effects of 17β-oestradiol on rat detrusor smooth muscle contractility [PDF]
, 2009 The aim of this study was to investigate the effect of 17β-oestradiol (E2) on detrusor smooth muscle contractility and its possible neuroprotective role against ischaemic-like condition, which could arise during overactive bladder disease.
Keith L. Brain +19 more
core +1 more source
Mitochondrial Modulation Of Spontaneous Ca2+ Oscillations In Portal Vein Smooth Muscle Myocytes [PDF]
Biophysical Journal, 2009 Transient increases in cytosolic Ca2+ concentration ([Ca2+]c) regulate many smooth muscle activities including contraction, transcription, growth and apoptosis. The onset of some processes involve sarcoplasmic reticulum Ca2+ release triggered by either inositol 1,4,5-trisphosphate (InsP3) or occurring spontaneously. Mitochondrial Ca2+ uptake influences
Olson, Marnie L. +5 more
openaire +1 more source