Results 221 to 230 of about 285,913 (271)

High-efficiency somatic mutagenesis in smooth muscle cells and cardiac myocytes in SM22?-Cre transgenic mice

genesis, 2005
The cytoskeletal protein SM22alpha is expressed in visceral and vascular smooth muscle cells (SMCs), in cardiac myocytes, and in the myotomal components of the somites during murine embryonic development. In this report, we describe the generation and characterization of transgenic mice expressing Cre-recombinase under the transcriptional control of ...
Lan Cheng, John J. Lepore, Edward E. Morrisey, Michael S. Parmacek, Min Min Lu, Patricia Mericko   +5 more
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Altered Ion Channel Activity in Murine Colonic Smooth Muscle Myocytes in an Experimental Colitis Model

Biochemical and Biophysical Research Communications, 2000
We have investigated the activity of calcium and potassium channels in a murine model of experimental colitis. Colonic myocytes from dextran sulphate sodium (DSS)-treated mice were examined by whole cell patch clamp techniques. Myeloperoxidase activity was enhanced 3. 5-fold in DSS-treated mouse colon.
AKBARALI HI, POTHOULAKIS C, CASTAGLIUOLO, IGNAZIO   +2 more
openaire   +5 more sources

The role of mechanical and humoral factors in growth regulation of vascular smooth muscle and cardiac myocytes

Current Opinion in Nephrology and Hypertension, 1993
Structural changes of the heart and blood vessels participate in the long-term regulation of the cardiovascular system. In hypertension and myocardial dysfunction, the adaptive process of cardiac and vascular remodeling may contribute to the pathophysiology and complications of these diseases.
V. Dzau
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Overexpression of human Hsp27 inhibits serum-induced proliferation in airway smooth muscle myocytes and confers resistance to hydrogen peroxide cytotoxicity [PDF]

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2007
Airway smooth muscle (ASM) hypertrophy and hyperplasia are characteristics of asthma that lead to thickening of the airway wall and obstruction of airflow. Very little is known about mechanisms underlying ASM remodeling, but in vascular smooth muscle, it is known that progression of atherosclerosis depends on the balance of myocyte proliferation and ...
Lisa Hanson, Jody L. Martin, Mariam Ba, Andrew J. Halayko, William T. Gerthoffer, Sonemany Salinthone   +5 more
openaire   +3 more sources

Synthesis and Expression of Tissue Factor Pathway Inhibitor by Serum-stimulated Fibroblasts, Vascular Smooth Muscle Cells and Cardiac Myocytes

Thrombosis and Haemostasis, 1999
SummaryTissue factor pathway inhibitor (TFPI) plays an important role in regulating tissue factor (TF)-initiated blood coagulation. Since serum stimulation of fibroblasts, vascular smooth muscle cells and cardiac myocytes in culture increases the expression of TF mRNA and antigen (Ag) in these cells, we hypothesized that serum may also induce increased
Steer Sa, W. Kisiel, Madhu S. Bajaj, M. N. Kuppuswamy, Bajaj Sp   +4 more
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Hypertension Differentially Affects the Expression of the Gap Junction Protein Connexin43 in Cardiac Myocytes and Aortic Smooth Muscle Cells

Advances in Experimental Medicine and Biology, 1997
Electrical and mechanical coupling of myocytes in heart and of smooth muscle cells in the aortic wall is thought to be mediated by intercellular channels aggregated at gap junctions. Connexin43 (Cx43) is one of the predominant membrane proteins forming junctional channels in the cardiovascular system.
Pascal Nicod, Jean-François Aubert, Paolo Meda, Jacques-Antoine Haefliger, Einar Castillo, Gérard Waeber, Bernard Waeber   +6 more
openaire   +4 more sources

Adenovirus-mediated Overexpression of Human Transforming Growth Factor-β1 in Rat Cardiac Fibroblasts, Myocytes and Smooth Muscle Cells

Journal of Molecular and Cellular Cardiology, 1996
Transforming growth factor-beta 1 (TGF-beta 1) is known to regulate cardiac cell function and its overexpression in the heart is thought to contribute to the development of cardiac hypertrophy and fibrosis. We wished to develop a high efficiency gene transfer method that could be used both in vitro and in vivo and result in the overexpression of TGF ...
Francisco Villarreal, Wolfgang H. Dillmann, Ann A. Lee, Frank J. Giordano   +3 more
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Leiomyoblastoma of the uterus: an immunohistochemical and electron microscopic study of distinctive tumours with immature smooth muscle cell differentiation mimicking fetal uterine myocytes

Histopathology, 2003
Aims:  We present three distinctive uterine tumours which exhibited immature smooth muscle differentiation mimicking smooth muscle cells of the fetal uterus.Methods and results:  The patients were 45, 46 and 49 years old, and all of them had simple hysterectomies.
Go Ogura, Toshimitsu Suzuki, Kazuo Watanabe   +2 more
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Inactivation of Calcium Channels in Vascular Smooth Muscle Myocytes

Cell Biochemistry and Biophysics, 2006
Many of the structural domains involved in Ca2+ channel (CACN) inactivation are also involved in determining their sensitivity to antagonist inhibition. We hypothesize that differences in inactivation properties and their structural determinants may suggest candidate domains as targets for the development of novel, selective antagonists.
Robert H. Cox, Martin Kathrins
openaire   +3 more sources

Adrenergic stimulation of diacylglycerol production in genital tract smooth muscle myocytes

In Vitro Cellular & Developmental Biology - Animal, 1993
Diacylglycerol (DAG) production has not been reported in previous studies that have characterized inositol phosphate production during alpha-1 adrenergic receptor signal transduction in the DDT1 MF-2 genital tract myocytes. The current study sought to measure norepinephrine (NE)-stimulated DAG production in these transformed myocytes utilizing thin ...
Mark Phillippe, R. Austin, Laura DiGiovonni   +2 more
openaire   +4 more sources