Results 21 to 30 of about 34,551 (223)
The use of calcium channel blockers in the treatment of cardiovascular diseases [PDF]
Arhiv za farmaciju, 2015 Voltage-sensitive calcium channels (L-type) mediate the entry of extracellular calcium into smooth muscle and cardiac myocytes and sinoatrial and atrioventricular nodal cells in response to electrical depolarization.
Đokić Mirjana
doaj +1 more source
Frontiers in Pharmacology, 2019 Norbormide is a toxicant selective for rats to which it induces a widespread vasoconstriction. In a recent paper, we hypothesized a role of ATP-sensitive potassium (KATP) channels in norbormide-induced vasoconstriction.
Simona Saponara +8 more
doaj +1 more source
Calcium currents in isolated rabbit coronary arterial smooth muscle myocytes.
The Journal of Physiology, 1990 1. Calcium inward currents were recorded from relaxed enzymatically isolated smooth muscle cells from the rabbit epicardial left descending coronary artery using a single‐pipette voltage‐clamp technique. Outward K+ currents were blocked with CsCl‐tetraethylammonium‐filled pipette solutions. 2. Relaxed coronary smooth muscle cells had a maximum diameter
J J, Matsuda, K A, Volk, E F, Shibata
openaire +3 more sources
Sources and regulation of nitric oxide synthesis in uterus smooth muscle cells [PDF]
The Ukrainian Biochemical Journal, 2019 It was proved that NO synthesis in isolated mitochondria of rat uterus smooth muscle depended on the entry of exogenous Ca2+ to mitochondria (inhibited by 1-10 mM Mg2+ in the absence of ATP and by 10 μM ruthenium red) and was suppressed by calmodulin ...
H. V. Danylovych +4 more
doaj +1 more source
Effects of polyamines on the muscarinic receptor‐operated cation current in guinea‐pig ileal smooth muscle myocytes [PDF]
British Journal of Pharmacology, 2004 The effects of extracellular and intracellular polyamines (PAs), spermine and putrescine, on the cation current (mICAT) evoked either by activating muscarinic receptors with carbachol or by intracellularly applied GTPγS (in the absence of carbachol) were studied using patch‐clamp recording techniques in single guinea‐pig ileal myocytes. Extracellular
Tsvilovskyy, V.V. +2 more
openaire +2 more sources
PLoS ONE, 2008 BackgroundHollow smooth muscle organs such as the bladder undergo significant changes in wall tension associated with filling and distension, with attendant changes in muscle tone.
Bin Wei +9 more
doaj +1 more source
Arquivos Brasileiros de Cardiologia, 1999 OBJECTIVE: To study the healing process of the myocardium in hypertensive rats undergoing inhibition of nitric oxide synthesis. METHODS: Two groups of animals were studied: one received L-NAME, 12mg/kg/day, and the other was a control group. The presence
Mônica Gomes Pessanha +2 more
doaj +1 more source
Frontiers in Physiology, 2020 Smooth muscle cells of the vasculature, viscera, and lungs generally express multiple α-subunits of the Kv7 voltage-gated potassium channel family, with increasing evidence that both Kv7.4 and Kv7.5 can conduct “M-currents” that are functionally ...
Lyubov I. Brueggemann +2 more
doaj +1 more source
Calix[4]arene C-99 inhibits myosin ATPase activity and changes the organization of contractile filaments of myometrium [PDF]
The Ukrainian Biochemical Journal, 2015 Calix[4]arenes are cup-like macrocyclic (polyphenolic) compounds, they are regarded as promising molecular “platforms” for the design of new physiologically active compounds.
R. D. Labyntseva, +5 more
doaj +1 more source
Piezo1 in Smooth Muscle Cells Is Involved in Hypertension-Dependent Arterial Remodeling
Cell Reports, 2015 The mechanically activated non-selective cation channel Piezo1 is a determinant of vascular architecture during early development. Piezo1-deficient embryos die at midgestation with disorganized blood vessels.
Kevin Retailleau +12 more
doaj +1 more source