Results 21 to 30 of about 287,296 (284)
The World Journal of Men's Health, 2023 Purpose: We aimed to investigate the mechanism of phenotypic transformation of corporal cavernosum smooth muscle cells (CCSMCs) under hypoxic conditions in vitro.
Xiongcai Zhou +6 more
doaj +1 more source
Scientific Reports, 2023 Cell-based therapy is a major focus for treatment of stress urinary incontinence (SUI). However, derivation of primary cells requires tissue biopsies, which often have adverse effects on patients. A recent study used human induced pluripotent stem cells (
M. Kibschull +6 more
doaj +1 more source
Mitochondrial Modulation Of Spontaneous Ca2+ Oscillations In Portal Vein Smooth Muscle Myocytes [PDF]
Biophysical Journal, 2009 Transient increases in cytosolic Ca2+ concentration ([Ca2+]c) regulate many smooth muscle activities including contraction, transcription, growth and apoptosis. The onset of some processes involve sarcoplasmic reticulum Ca2+ release triggered by either inositol 1,4,5-trisphosphate (InsP3) or occurring spontaneously. Mitochondrial Ca2+ uptake influences
Marnie L. Olson +5 more
openaire +2 more sources
Immunolocalization of KATP channel subunits in mouse and rat cardiac myocytes and the coronary vasculature. [PDF]
, 2005 BACKGROUND: Electrophysiological data suggest that cardiac KATP channels consist of Kir6.2 and SUR2A subunits, but the distribution of these (and other KATP channel subunits) is poorly defined.
Artman, M +13 more
core +3 more sources
Reproductive Biology and Endocrinology, 2008 Background Myometrial smooth myocytes contract as a result of electrical signalling via a process called excitation-contraction coupling. This process is understood in great detail at the cellular level but the generation and coordination of electrical ...
Van Lommel Alfons +6 more
doaj +1 more source
Distance constraints on activation of TRPV4 channels by AKAP150-bound PKCα in arterial myocytes. [PDF]
, 2017 TRPV4 (transient receptor potential vanilloid 4) channels are Ca2+-permeable channels that play a key role in regulating vascular tone. In arterial myocytes, opening of TRPV4 channels creates local increases in Ca2+ influx, detectable optically as "TRPV4
Moreno, Claudia M +6 more
core +3 more sources
Distribution of phenotypically disparate myocyte subpopulations in airway smooth muscle
Canadian Journal of Physiology and Pharmacology, 2005 Phenotype and functional heterogeneity of airway smooth muscle (ASM) cells in vitro is well known, but there is limited understanding of these features in vivo. We tested whether ASM is composed of myocyte subsets differing in contractile phenotype marker expression. We used flow cytometry to compare smooth muscle myosin heavy chain (smMHC) and smooth
Halayko, AJ +5 more
openaire +4 more sources
Validation of XE991 use as a Selective Irreversible Blocker of Native Kv7 Channels in Smooth Muscle Myocytes [PDF]
Biophysical Journal, 2012 A concern was recently raised about the selectivity of XE991 and its use as a Kv7 channel blocker in single cell electrophysiology and in vitro functional assays. In the present study, we evaluated the effects of XE991 on different components of the endogenous delayed rectifier potassium currents recorded in freshly isolated guinea pig airway myocytes ...
Lyubov I. Brueggemann, Kenneth L. Byron
openaire +2 more sources
The use of calcium channel blockers in the treatment of cardiovascular diseases [PDF]
Arhiv za farmaciju, 2015 Voltage-sensitive calcium channels (L-type) mediate the entry of extracellular calcium into smooth muscle and cardiac myocytes and sinoatrial and atrioventricular nodal cells in response to electrical depolarization.
Đokić Mirjana
doaj +1 more source
American Journal of Physiology. Heart and Circulatory Physiology, 2018 Hypoxic preconditioning, the protective effect of brief, intermittent hypoxic or ischemic episodes on subsequent more severe hypoxic episodes, has been known for 30 yr from studies on cardiac muscle.
Asmaa M Almohanna, S. Wray
semanticscholar +1 more source