Results 21 to 30 of about 62,427 (259)

Insights into Activation Mechanisms of Store-Operated TRPC1 Channels in Vascular Smooth Muscle. [PDF]

, 2020
In vascular smooth muscle cells (VMSCs), the stimulation of store-operated channels (SOCs) mediate Ca2+ influx pathways which regulate important cellular functions including contraction, proliferation, migration, and growth that are associated with the ...
Albert, AP, Baudel, MASM-A, Large, WA, Shi, J   +3 more
core   +1 more source

Divergent differentiation paths in airway smooth muscle culture: induction of functionally contractile myocytes [PDF]

American Journal of Physiology-Lung Cellular and Molecular Physiology, 1999
We tested the hypothesis that prolonged serum deprivation would allow a subset of cultured airway myocytes to reacquire the abundant contractile protein content, marked shortening capacity, and elongated morphology characteristic of contractile cells within intact tissue. Passage 1 or 2 canine tracheal smooth muscle (SM) cells were grown to confluence,
A J, Halayko, B, Camoretti-Mercado, S M, Forsythe, J E, Vieira, R W, Mitchell, M E, Wylam, M B, Hershenson, J, Solway   +7 more
openaire   +2 more sources

Key role for Kv11.1 (ether‐a‐go‐go related gene) channels in rat bladder contractility

Physiological Reports, 2023
In addition, to their established role in cardiac myocytes and neurons, ion channels encoded by ether‐a‐go‐go‐related genes (ERG1‐3 or kcnh2,3 and 6) (kcnh2) are functionally relevant in phasic smooth muscle.
Vincenzo Barrese, Zena Wehbe, Alice Linden, Sarah McDowell, Elizabeth Forrester, Oleksander Povstyan, Karen D. McCloskey, Iain A. Greenwood   +7 more
doaj   +1 more source

Smooth Muscle Cells, But Not Myocytes, of Host Origin in Transplanted Human Hearts [PDF]

Circulation, 2002
Background — There is increasing evidence to support a role for stem cells in the regeneration and repair of the human cardiovascular system.
Ruchira, Glaser, Min Min, Lu, Navneet, Narula, Jonathan A, Epstein   +3 more
openaire   +2 more sources

Myocardin Reverses Hypoxia-Inducible Factor-1α Mediated Phenotypic Modulation of Corpus Cavernosum Smooth Muscle Cells in Hypoxia Induced by Cobalt Chloride

The World Journal of Men's Health, 2023
Purpose: We aimed to investigate the mechanism of phenotypic transformation of corporal cavernosum smooth muscle cells (CCSMCs) under hypoxic conditions in vitro.
Xiongcai Zhou, Chao Luo, Junhong Fan, Guangqian Gao, Tao Wang, Haibo Zhang, Anyang Wei   +6 more
doaj   +1 more source

Differentiation of patient-specific void urine-derived human induced pluripotent stem cells to fibroblasts and skeletal muscle myocytes

Scientific Reports, 2023
Cell-based therapy is a major focus for treatment of stress urinary incontinence (SUI). However, derivation of primary cells requires tissue biopsies, which often have adverse effects on patients. A recent study used human induced pluripotent stem cells (
M. Kibschull, T. T. N. Nguyen, T. Chow, M. Alarab, S. J. Lye, I. Rogers, O. Shynlova   +6 more
doaj   +1 more source

The Role of Mechanotransduction on Vascular Smooth Muscle Myocytes Cytoskeleton and Contractile Function [PDF]

The Anatomical Record, 2014
ABSTRACTSmooth muscle (SM) exhibits a highly organized structural hierarchy that extends over multiple spatial scales to perform a wide range of functions at the cellular, tissue, and organ levels. Early efforts primarily focused on understanding vascular SM (VSM) function through biochemical signaling.
George J C, Ye, Alexander P, Nesmith, Kevin Kit, Parker   +2 more
openaire   +2 more sources

Steady-state modulation of voltage-gated K+ channels in rat arterial smooth muscle by cyclic AMP-dependent protein kinase and protein phosphatase 2B [PDF]

, 2015
Voltage-gated potassium channels (Kv) are important regulators of membrane potential in vascular smooth muscle cells, which is integral to controlling intracellular Ca2+ concentration and regulating vascular tone. Previous work indicates that Kv channels
A Adebiyi, A Cheong, A Cogolludo, A Moreno-Dominguez, AJ Wilson, AM Brainard, B Kyle, B Razani, B Razani, C Dart, C Dart, Carl P. Nelson, CL Moore, CP Nelson, CP Nelson, DP McEwen, DW Carr, EA Aiello, EA Aiello, EA Ko, EA Ko, F Plane, GC Wellman, GI Purves, H Li, H Miyoshi, HS Mason, IA Greenwood, J Couet, J Moral-Sanz, JB Stott, JD Scott, JD Turner, Jennifer L. Brignell, JM Quayle, Jonathon M. Willets, JR Martens, KD Luykenaar, KS Park, LF Santana, LJ Sampson, LM Davies, M Colledge, Mark S. Shapiro, Matthew D. Perry, MF Navedo, MG Gold, MT Nelson, NM Alto, NN Orie, Noel W. Davies, O Clement-Chomienne, P Skroblin, R. A. John Challiss, RD Rainbow, RD Rainbow, RD Rainbow, RH Cox, RT Dobrowsky, SA Barman, VM Coghlan, Y Hayabuchi, Y Hayabuchi, Y Hayabuchi, Y Yang   +64 more
core   +7 more sources

Mitochondrial Modulation Of Spontaneous Ca2+ Oscillations In Portal Vein Smooth Muscle Myocytes [PDF]

Biophysical Journal, 2009
Transient increases in cytosolic Ca2+ concentration ([Ca2+]c) regulate many smooth muscle activities including contraction, transcription, growth and apoptosis. The onset of some processes involve sarcoplasmic reticulum Ca2+ release triggered by either inositol 1,4,5-trisphosphate (InsP3) or occurring spontaneously. Mitochondrial Ca2+ uptake influences
Olson, Marnie L., Chalmers, Susan, Avlonitis, Nicolaos, Stanton-Humphreys, Megan N., Conway, Stuart J., McCarron, John G.   +5 more
openaire   +1 more source

Arterial smooth muscle cell PKD2 (TRPP1) channels regulate systemic blood pressure

eLife, 2018
Systemic blood pressure is determined, in part, by arterial smooth muscle cells (myocytes). Several Transient Receptor Potential (TRP) channels are proposed to be expressed in arterial myocytes, but it is unclear if these proteins control physiological ...
Simon Bulley, Carlos Fernández-Peña, Raquibul Hasan, M Dennis Leo, Padmapriya Muralidharan, Charles E Mackay, Kirk W Evanson, Luiz Moreira-Junior, Alejandro Mata-Daboin, Sarah K Burris, Qian Wang, Korah P Kuruvilla, Jonathan H Jaggar   +12 more
doaj   +1 more source