Results 31 to 40 of about 285,913 (271)

Distance constraints on activation of TRPV4 channels by AKAP150-bound PKCα in arterial myocytes. [PDF]

, 2017
TRPV4 (transient receptor potential vanilloid 4) channels are Ca2+-permeable channels that play a key role in regulating vascular tone. In arterial myocytes, opening of TRPV4 channels creates local increases in Ca2+ influx, detectable optically as "TRPV4
Moreno, Claudia M, Navedo, Manuel F, O'Dwyer, Samantha, Santana, L Fernando, Sato, Daisuke, Tajada, Sendoa, Woods, Sean   +6 more
core   +3 more sources

Hypoxic conditioning in blood vessels and smooth muscle tissues: effects on function, mechanisms, and unknowns.

American Journal of Physiology. Heart and Circulatory Physiology, 2018
Hypoxic preconditioning, the protective effect of brief, intermittent hypoxic or ischemic episodes on subsequent more severe hypoxic episodes, has been known for 30 yr from studies on cardiac muscle.
Asmaa M Almohanna, S. Wray
semanticscholar   +1 more source

Activation of native TRPC1/C5/C6 channels by endothelin-1 is mediated by both PIP3 and PIP2 in rabbit coronary artery myocytes [PDF]

, 2009
We investigate activation mechanisms of native TRPC1/C5/C6 channels (termed TRPC1 channels) by stimulation of endothelin-1 (ET-1) receptor subtypes in freshly dispersed rabbit coronary artery myocytes using single channel recording and ...
Ahmmed, Albert, Albert, Albert, Albert, Albert, Albert, Albert, Anthony P. Albert, Boualleque, Clapham, Davenport, Davenport, Drummond, Fukami, Hamill, Hardie, Helliwell, Inoue, Ivey, Kawanabe, Kinlay, Kwon, Large, Lemonnier, Liu, Miwa, Nakanishi, Nilius, Otsuguro, Peppiatt-Wildman, Rohacs, Saleh, Saleh, Saleh, Schiffrin, Sohag N. Saleh, Sugawara, Sumner, Trebak, Tseng, Vanhaesebroeck, Voets, Wang, William A. Large   +44 more
core   +2 more sources

The Selective Rat Toxicant Norbormide Blocks KATP Channels in Smooth Muscle Cells But Not in Insulin-Secreting Cells

Frontiers in Pharmacology, 2019
Norbormide is a toxicant selective for rats to which it induces a widespread vasoconstriction. In a recent paper, we hypothesized a role of ATP-sensitive potassium (KATP) channels in norbormide-induced vasoconstriction.
Simona Saponara, Fabio Fusi, Ottavia Spiga, Alfonso Trezza, Brian Hopkins, Brian Hopkins, Margaret A. Brimble, David Rennison, Sergio Bova   +8 more
doaj   +1 more source

Sources and regulation of nitric oxide synthesis in uterus smooth muscle cells [PDF]

The Ukrainian Biochemical Journal, 2019
It was proved that NO synthesis in isolated mitochondria of rat uterus smooth muscle depended on the entry of exogenous Ca2+ to mitochondria (inhibited by 1-10 mM Mg2+ in the absence of ATP and by 10 μM ruthenium red) and was suppressed by calmodulin ...
H. V. Danylovych , Yu. V. Danylovych, T. V. Bohach, S. O. Kosterin, S. O. Kosterin   +4 more
doaj   +1 more source

Steady-state modulation of voltage-gated K+ channels in rat arterial smooth muscle by cyclic AMP-dependent protein kinase and protein phosphatase 2B [PDF]

, 2015
Voltage-gated potassium channels (Kv) are important regulators of membrane potential in vascular smooth muscle cells, which is integral to controlling intracellular Ca2+ concentration and regulating vascular tone. Previous work indicates that Kv channels
A Adebiyi, A Cheong, A Cogolludo, A Moreno-Dominguez, AJ Wilson, AM Brainard, B Kyle, B Razani, B Razani, C Dart, C Dart, Carl P. Nelson, CL Moore, CP Nelson, CP Nelson, DP McEwen, DW Carr, EA Aiello, EA Aiello, EA Ko, EA Ko, F Plane, GC Wellman, GI Purves, H Li, H Miyoshi, HS Mason, IA Greenwood, J Couet, J Moral-Sanz, JB Stott, JD Scott, JD Turner, Jennifer L. Brignell, JM Quayle, Jonathon M. Willets, JR Martens, KD Luykenaar, KS Park, LF Santana, LJ Sampson, LM Davies, M Colledge, Mark S. Shapiro, Matthew D. Perry, MF Navedo, MG Gold, MT Nelson, NM Alto, NN Orie, Noel W. Davies, O Clement-Chomienne, P Skroblin, R. A. John Challiss, RD Rainbow, RD Rainbow, RD Rainbow, RH Cox, RT Dobrowsky, SA Barman, VM Coghlan, Y Hayabuchi, Y Hayabuchi, Y Hayabuchi, Y Yang   +64 more
core   +7 more sources

Cardioprotective effects of Cu(II)ATSM in human vascular smooth muscle cells and cardiomyocytes mediated by Nrf2 and DJ-1

Scientific Reports, 2016
Cu(II)ATSM was developed as a hypoxia sensitive positron emission tomography agent. Recent reports have highlighted the neuroprotective properties of Cu(II)ATSM, yet there are no reports that it confers cardioprotection.
S. Srivastava, P. Blower, A. Aubdool, R. Hider, G. Mann, R. Siow   +5 more
semanticscholar   +1 more source

Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy [PDF]

, 2003
It is generally believed that increase in adult contractile cardiac mass can be accomplished only by hypertrophy of existing myocytes. Documentation of myocardial regeneration in acute stress has challenged this dogma and led to the proposition that ...
Anversa P., CASTALDO, CLOTILDE, Kajstura J, Leri A, Nadal Ginard B, Quaini E, Quaini F, Tasca G, Torella D, Urbanek K   +9 more
core   +1 more source

Targeting protein–protein interactions within the cyclic AMP signaling system as a therapeutic strategy for cardiovascular disease [PDF]

, 2013
The cAMP signaling system can trigger precise physiological cellular responses that depend on the fidelity of many protein–protein interactions, which act to bring together signaling intermediates at defined locations within cells.
Brunton, Donald H Maurice, Dreiza, George S Baillie, Hayes, Li, Louisa CY Lee, Shenoy, Tavalin   +8 more
core   +1 more source

New perspectives to repair a broken heart [PDF]

, 2009
The aim of cardiac cell therapy is to restore at least in part the functionality of the diseased or injured myocardium by the use of stem/ progenitor cells.
BARILE, Lucio, CHIMENTI, ISOTTA, DI CONSIGLIO, ALBERTO, FORTE, ELVIRA, FRATI, GIACOMO, GAETANI, ROBERTO, GIACOMELLO, Alessandro, IONTA, VITTORIA, MESSINA, ELISA, MIRALDI, Fabio   +9 more
core   +1 more source