Results 31 to 40 of about 34,551 (223)

Transgenic Overexpression of β2-Adrenergic Receptors in Airway Smooth Muscle Alters Myocyte Function and Ablates Bronchial Hyperreactivity [PDF]

Journal of Biological Chemistry, 1999
beta(2)-Adrenergic receptors (beta(2)AR) act to relax airway smooth muscle and can serve to counteract hyperresponsiveness, although the effect may not be ablative even in the presence of exogenous agonist. Within this signaling cascade that ultimately transduces smooth muscle relaxation, a significant "spare receptor" pool has been hypothesized to be ...
D W, McGraw, S L, Forbes, L A, Kramer, D P, Witte, C N, Fortner, R J, Paul, S B, Liggett   +6 more
openaire   +2 more sources

Muller Muscle of the Upper Eyelid: Histopathological Features of Congenital and Acquired Ptosis

Oftalʹmologiâ, 2020
Purpose: to study the histological features of the Muller muscle of the upper eyelid in patients with congenital and acquired ptosis to understand the mechanism of ptosis. Material and methods.
M. G. Kataev, A. V. Shatskikh, M. A. Zaharova, Z. R. Dzagurova, A. V. Shahmatova, N. M. Kataeva   +5 more
doaj   +1 more source

Endothelial Myocyte Enhancer Factor 2c Inhibits Migration of Smooth Muscle Cells Through Fenestrations in the Internal Elastic Lamina [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2017
Objective— Laminar flow activates myocyte enhancer factor 2 (MEF2) transcription factors in vitro to induce expression of atheroprotective genes in the endothelium.
Yao Wei, Lu, Anthony M, Lowery, Li-Yan, Sun, Harold A, Singer, Guohao, Dai, Alejandro P, Adam, Peter A, Vincent, John J, Schwarz   +7 more
openaire   +2 more sources

Two isoforms of Trpm8 in rat vas deferens

Біологічні студії, 2019
Trpm8 is a nonselective Ca2+-permeable ion channel activated by temperatures below 28 °C and cooling chemical compounds such as menthol and icilin. Trpm8 is expressed in sensory neurons where it functions for temperature detection. However, Trpm8 is also
K. Gulak, A. Kondratskyi
doaj   +1 more source

Suppression of cardiomyocyte functions by β-CTX isolated from the Thai king cobra (Ophiophagus hannah) venom via an alternative method [PDF]

Journal of Venomous Animals and Toxins including Tropical Diseases, 2020
Background: Beta-cardiotoxin (β-CTX), the three-finger toxin isolated from king cobra (Ophiophagus hannah) venom, possesses β-blocker activity as indicated by its negative chronotropy and its binding property to both β-1 and β-2 adrenergic receptors and ...
Tuchakorn Lertwanakarn, Montamas Suntravat, Elda E. Sanchez, Worakan Boonhoh, R. John Solaro, Beata M. Wolska, Jody L. Martin, Pieter P. de Tombe, Kittipong Tachampa   +8 more
doaj   +1 more source

A computational model predicts sex-specific responses to calcium channel blockers in mammalian mesenteric vascular smooth muscle

eLife
The function of the smooth muscle cells lining the walls of mammalian systemic arteries and arterioles is to regulate the diameter of the vessels to control blood flow and blood pressure. Here, we describe an in silico model, which we call the ‘Hernandez–
Gonzalo Hernandez-Hernandez, Samantha C O'Dwyer, Pei-Chi Yang, Collin Matsumoto, Mindy Tieu, Zhihui Fong, Timothy J Lewis, L Fernando Santana, Colleen E Clancy   +8 more
doaj   +1 more source

TRPV4-Like Non-selective Cation Currents in Cultured Aortic Myocytes

Journal of Pharmacological Sciences, 2008
In this study, we provide evidence of critical changes in the expression of non-selective cation currents (NSCC) during culture in rat aortic myocytes.
Ryoichi Tanaka, Katsuhiko Muraki, Susumu Ohya, Hisao Yamamura, Noriyuki Hatano, Yuka Itoh, Yuji Imaizumi   +6 more
doaj   +1 more source

Myocardial Perfusion Defects in Hypertrophic Cardiomyopathy Mutation Carriers

Journal of the American Heart Association, EarlyView., 2021
Background Impaired myocardial blood flow (MBF) in the absence of epicardial coronary disease is a feature of hypertrophic cardiomyopathy (HCM). Although most evident in hypertrophied or scarred segments, reduced MBF can occur in apparently normal segments.
Rebecca K. Hughes, Claudia Camaioni, João B. Augusto, Kristopher Knott, Ellie Quinn, Gabriella Captur, Andreas Seraphim, George Joy, Petros Syrris, Perry M. Elliott, Saidi Mohiddin, Peter Kellman, Hui Xue, Luis R. Lopes, James C. Moon   +14 more
wiley   +1 more source

Validation of XE991 use as a Selective Irreversible Blocker of Native Kv7 Channels in Smooth Muscle Myocytes [PDF]

Biophysical Journal, 2012
A concern was recently raised about the selectivity of XE991 and its use as a Kv7 channel blocker in single cell electrophysiology and in vitro functional assays. In the present study, we evaluated the effects of XE991 on different components of the endogenous delayed rectifier potassium currents recorded in freshly isolated guinea pig airway myocytes ...
Brueggemann, Lyubov I., Byron, Kenneth L.   +1 more
openaire   +1 more source

Immune Checkpoint Inhibitor–Related Myositis and Associated Triad Overlap Syndrome

Arthritis Care &Research, EarlyView.
Objective Immune checkpoint inhibitor (ICI) myositis is a rare but a highly morbid condition, particularly with the ICI myositis triad syndrome of myositis, myocarditis, and myasthenia gravis. We report the clinical characteristics of ICI myositis and all‐cause mortality in these patients.
Selene Rubino, Grant W. Cannon, Brian C. Sauer, Jorge Rojas, Gregory J. Stoddard, Gary A. Kunkel, Jessica A. Walsh, Bryant R. England, Joshua F. Baker, Tawnie J. Braaten   +9 more
wiley   +1 more source