Results 51 to 60 of about 287,296 (284)

Two isoforms of Trpm8 in rat vas deferens

Біологічні студії, 2019
Trpm8 is a nonselective Ca2+-permeable ion channel activated by temperatures below 28 °C and cooling chemical compounds such as menthol and icilin. Trpm8 is expressed in sensory neurons where it functions for temperature detection. However, Trpm8 is also
K. Gulak, A. Kondratskyi
doaj   +1 more source

Transgenic Overexpression of β2-Adrenergic Receptors in Airway Smooth Muscle Alters Myocyte Function and Ablates Bronchial Hyperreactivity [PDF]

Journal of Biological Chemistry, 1999
beta(2)-Adrenergic receptors (beta(2)AR) act to relax airway smooth muscle and can serve to counteract hyperresponsiveness, although the effect may not be ablative even in the presence of exogenous agonist. Within this signaling cascade that ultimately transduces smooth muscle relaxation, a significant "spare receptor" pool has been hypothesized to be ...
David P. Witte, Stephen B. Liggett, Christopher N. Fortner, Lisa A. Kramer, Dennis W. McGraw, Richard J. Paul, Susan L. Forbes   +6 more
openaire   +3 more sources

A computational model predicts sex-specific responses to calcium channel blockers in mammalian mesenteric vascular smooth muscle

eLife
The function of the smooth muscle cells lining the walls of mammalian systemic arteries and arterioles is to regulate the diameter of the vessels to control blood flow and blood pressure. Here, we describe an in silico model, which we call the ‘Hernandez–
Gonzalo Hernandez-Hernandez, Samantha C O'Dwyer, Pei-Chi Yang, Collin Matsumoto, Mindy Tieu, Zhihui Fong, Timothy J Lewis, L Fernando Santana, Colleen E Clancy   +8 more
doaj   +1 more source

The lack of the Celf2a splicing factor converts a Duchenne genotype into a Becker phenotype [PDF]

, 2016
Substitutions, deletions and duplications in the dystrophin gene lead to either the severe Duchenne muscular dystrophy (DMD) or mild Becker muscular dystrophy depending on whether out-of-frame or in-frame transcripts are produced.
BOZZONI, Irene, Briganti, F, LEGNINI, IVANO, MARTONE, Julie, MORLANDO, MARIANGELA, Picillo, E, Politano, L, STHANDIER, Olga Elena   +7 more
core   +2 more sources

Endothelial Myocyte Enhancer Factor 2c Inhibits Migration of Smooth Muscle Cells Through Fenestrations in the Internal Elastic Lamina [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2017
Objective— Laminar flow activates myocyte enhancer factor 2 (MEF2) transcription factors in vitro to induce expression of atheroprotective genes in the endothelium. Here we sought to establish the role of Mef2c in the vascular endothelium in vivo. Approach and Results—
Peter Vincent, Harold A. Singer, Anthony M. Lowery, Li-Yan Sun, Yao Wei Lu, John J. Schwarz, Alejandro P. Adam, Guohao Dai   +7 more
openaire   +3 more sources

Resident phenotypically modulated vascular smooth muscle cells in healthy human arteries. [PDF]

, 2012
Vascular interstitial cells (VICs) are non-contractile cells with filopodia previously described in healthy blood vessels of rodents and their function remains unknown.
Greenwood, IA, Harhun, MI, Huggins, CL, Khong, TK, Moss, RF, Raje, D, Ratnasingham, K, Reddy, M, Szewczyk, K, Vasilikostas, G, Wan, A   +10 more
core   +1 more source

Cellular distribution of smooth muscle actins during mammalian embryogenesis: expression of the alpha-vascular but not the gamma- enteric isoform in differentiating striated myocytes

Journal of Cell Biology, 1989
The cellular distribution of the alpha-vascular and gamma-enteric smooth muscle actin isoforms was analyzed in rat embryos from gestational day (gd) 8 through the first neonatal week by in situ antigen localization using isoactin specific monoclonal ...
N. Sawtell, James L. Lessard
semanticscholar   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Comparative Statistical Mechanics of Muscle and Non-Muscle Contractile Systems: Stationary States of Near-Equilibrium Systems in A Linear Regime

Entropy, 2017
A. Huxley’s equations were used to determine the mechanical properties of muscle myosin II (MII) at the molecular level, as well as the probability of the occurrence of the different stages in the actin–myosin cycle.
Yves Lecarpentier, Victor Claes, Xénophon Krokidis, Jean-Louis Hébert, Oumar Timbely, François-Xavier Blanc, Francine Michel, Alexandre Vallée   +7 more
doaj   +1 more source

Cardiac stem cells: A promising treatment option for heart failure. [PDF]

, 2012
Cardiovascular diseases are the most common cause of death in the world. The development of heart failure is mainly due to the loss of cardiomyocytes following myocardial infarction and the absence of endogenous myocardial repair.
Huang, Lan, Zhao, Xiaohui
core   +1 more source