Evidence For Phosphorylation-Dependent Modulation of BK Channel Activity in Vascular Smooth Muscle (VSM) Myocytes and Resistance Arteries [PDF]
Biophysical Journal, 2016 VSM excitability is regulated by large conductance, calcium-activated K+ (BK) channels. We have previously reported that type I cGMP-dependent protein kinase (cGKI) phosphorylates the BK channel at key serine residues, leading to augmented BK current magnitude. Here, we investigate the cellular mechanisms regulating the temporal pattern (i.e. onset and
Barry D. Kyle +2 more
openaire +2 more sources
Suppression of cardiomyocyte functions by β-CTX isolated from the Thai king cobra (Ophiophagus hannah) venom via an alternative method [PDF]
Journal of Venomous Animals and Toxins including Tropical Diseases, 2020 Background: Beta-cardiotoxin (β-CTX), the three-finger toxin isolated from king cobra (Ophiophagus hannah) venom, possesses β-blocker activity as indicated by its negative chronotropy and its binding property to both β-1 and β-2 adrenergic receptors and ...
Tuchakorn Lertwanakarn +8 more
doaj +1 more source
Transgenic Overexpression of β2-Adrenergic Receptors in Airway Smooth Muscle Alters Myocyte Function and Ablates Bronchial Hyperreactivity [PDF]
Journal of Biological Chemistry, 1999 beta(2)-Adrenergic receptors (beta(2)AR) act to relax airway smooth muscle and can serve to counteract hyperresponsiveness, although the effect may not be ablative even in the presence of exogenous agonist. Within this signaling cascade that ultimately transduces smooth muscle relaxation, a significant "spare receptor" pool has been hypothesized to be ...
David P. Witte +6 more
openaire +3 more sources
Caveolin-3 differentially orchestrates cholinergic and serotonergic constriction of murine airways [PDF]
, 2018 The mechanisms of controlling airway smooth muscle (ASM) tone are of utmost clinical importance as inappropriate constriction is a hallmark in asthma and chronic obstructive pulmonary disease.
Hollenhorst, M. I. +7 more
core +2 more sources
Two isoforms of Trpm8 in rat vas deferens
Біологічні студії, 2019 Trpm8 is a nonselective Ca2+-permeable ion channel activated by temperatures below 28 °C and cooling chemical compounds such as menthol and icilin. Trpm8 is expressed in sensory neurons where it functions for temperature detection. However, Trpm8 is also
K. Gulak, A. Kondratskyi
doaj +1 more source
Muller Muscle of the Upper Eyelid: Histopathological Features of Congenital and Acquired Ptosis
Oftalʹmologiâ, 2020 Purpose: to study the histological features of the Muller muscle of the upper eyelid in patients with congenital and acquired ptosis to understand the mechanism of ptosis. Material and methods.
M. G. Kataev +5 more
doaj +1 more source
Endothelial Myocyte Enhancer Factor 2c Inhibits Migration of Smooth Muscle Cells Through Fenestrations in the Internal Elastic Lamina [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2017 Objective— Laminar flow activates myocyte enhancer factor 2 (MEF2) transcription factors in vitro to induce expression of atheroprotective genes in the endothelium. Here we sought to establish the role of Mef2c in the vascular endothelium in vivo. Approach and Results—
Peter Vincent +7 more
openaire +3 more sources
Resident phenotypically modulated vascular smooth muscle cells in healthy human arteries. [PDF]
, 2012 Vascular interstitial cells (VICs) are non-contractile cells with filopodia previously described in healthy blood vessels of rodents and their function remains unknown.
Greenwood, IA +10 more
core +1 more source
Cardiac stem cells: A promising treatment option for heart failure. [PDF]
, 2012 Cardiovascular diseases are the most common cause of death in the world. The development of heart failure is mainly due to the loss of cardiomyocytes following myocardial infarction and the absence of endogenous myocardial repair.
Huang, Lan, Zhao, Xiaohui
core +1 more source
Advanced Functional Materials, EarlyView.Oct4‐nanoscript, a biomimetic nanoparticle‐based artificial transcription factor, precisely regulates cellular rejuvenation by activating Oct4 target genes, restoring epigenetic marks, and reducing DNA damage. In a progeria model, it effectively rescued aging‐associated pathologies and extended lifespan.
Hongwon Kim +8 more
wiley +1 more source