Results 1 to 10 of about 87,129 (185)
CD8+ T cells drive myofibroblast activation and contraction via JAK/STAT3 and TGFβ signaling [PDF]
iScienceSummary: Fibrosis in rheumatic connective tissue diseases is marked by CD8+ T cell and pro-fibrotic myofibroblast infiltration, though the role of CD8+ T cells in myofibroblast activity remains unexplored.
Theodoros Ioannis Papadimitriou +10 more
doaj +2 more sources
Structure–Activity Relationships of N-Acyl Dopamines in Inhibiting Myofibroblast Transdifferentiation of Retinal Pigment Epithelial Cells [PDF]
BiomoleculesAberrant wound healing in the retina can manifest as proliferative vitreoretinopathy (PVR), which involves the myofibroblast transdifferentiation of retinal pigment epithelial (RPE) cells.
Dandan Zhao +8 more
doaj +2 more sources
Platelet Polyphosphate Signals Through NFκB to Induce Myofibroblast Differentiation [PDF]
BiomoleculesMyofibroblasts drive wound healing and fibrotic disease through generation of contractile force to promote wound closure and production of matrix proteins to generate scar tissue.
Patrick M. Suess +4 more
doaj +2 more sources
A Role of Myocardin Related Transcription Factor-A (MRTF-A) in Scleroderma Related Fibrosis. [PDF]
, 2015 In scleroderma (systemic sclerosis, SSc), persistent activation of myofibroblast leads to severe skin and organ fibrosis resistant to therapy. Increased mechanical stiffness in the involved fibrotic tissues is a hallmark clinical feature and a cause of ...
Abraham, D +11 more
core +8 more sources
Cells, 2021 During atrial fibrillation, cardiac tissue undergoes different remodeling processes at different scales from the molecular level to the tissue level. One central player that contributes to both electrical and structural remodeling is the myofibroblast ...
Jorge Sánchez +4 more
doaj +1 more source
Journal of Translational Medicine, 2023 Background Silica-induced pulmonary fibrosis (silicosis) is a diffuse interstitial fibrotic disease characterized by the massive deposition of extracellular matrix in lung tissue.
Yaqian Qu +12 more
doaj +1 more source
Current Opinion in Rheumatology, 2013 Interest in the myofibroblast as a key player in propagation of chronic progressive fibrosis continues to elicit many publications, with focus on its cellular origins and the mechanisms underpinning their differentiation and/or transition. The objective of the review is to highlight this recent progress.The epithelial origin of the myofibroblast in ...
Biao, Hu, Sem H, Phan
openaire +2 more sources
Phosphodiesterase type 10A inhibitor attenuates lung fibrosis by targeting myofibroblast activation
iScience, 2023 Summary: Pulmonary fibrosis (PF) is a fatal and irreversible respiratory disease accompanied by excessive fibroblast activation. Previous studies have suggested that cAMP signaling pathway and cGMP-PKG signaling pathway are continuously down-regulated in
Ya-Jun Li +8 more
doaj +1 more source
Myofibroblasts. II. Intestinal subepithelial myofibroblasts [PDF]
American Journal of Physiology-Cell Physiology, 1999 Intestinal subepithelial myofibroblasts (ISEMF) and the interstitial cells of Cajal are the two types of myofibroblasts identified in the intestine. Intestinal myofibroblasts are activated and proliferate in response to various growth factors, particularly the platelet-derived growth factor (PDGF) family, which includes PDGF-BB and stem cell factor ...
D W, Powell +5 more
openaire +2 more sources
Biomedicines, 2022 Myofibroblast activation is a cellular response elicited by a variety of physiological or pathological insults whereby cells initiate a coordinated response intended to eradicate the insult and then revert back to a basal state.
Naiyou Liu +9 more
doaj +1 more source