Results 21 to 30 of about 87,228 (284)

Novel Omega-3 Fatty Acid Epoxygenase Metabolite Reduces Kidney Fibrosis. [PDF]

, 2016
Cytochrome P450 (CYP) monooxygenases epoxidize the omega-3 polyunsaturated fatty acid (PUFA) docosahexaenoic acid into novel epoxydocosapentaenoic acids (EDPs) that have multiple biological actions.
Hammock, Bruce D, Hye Khan, Md Abdul, Imig, John D, Lee, Kin Sing Stephen, Levick, Scott P, Sharma, Amit   +5 more
core   +6 more sources

Multicentric myofibroblastic sarcoma [PDF]

BMJ Case Reports, 2014
We report a case of synchronous, multicentric low-grade myofibroblastic sarcoma presenting in a 62-year-old man. He initially presented with inflammatory symmetric polyarthritis and adhesive capsulitis of his shoulder and hips bilaterally and did not respond to a trial of disease modifying antirheumatic drugs.
Mihir Dilip, Wechalekar, Oliver, Ayres, Gelareh, Farshid, Mark, Clayer, Leslie G, Cleland   +4 more
openaire   +2 more sources

Endothelial to mesenchymal transition (EndoMT) in the pathogenesis of Systemic Sclerosis-associated pulmonary fibrosis and pulmonary arterial hypertension. Myth or reality? [PDF]

, 2016
Systemic Sclerosis (SSc) is a systemic autoimmune disease characterized by progressive fibrosis of skin and multiple internal organs and severe functional and structural microvascular alterations.
Jimenez, Sergio A., Piera-Velazquez, Sonsoles   +1 more
core   +2 more sources

Recovery of Altered Diabetic Myofibroblast Heterogeneity and Gene Expression Are Associated with CD301b+ Macrophages

Biomedicines, 2021
Diabetic wound healing is associated with impaired function and reduced numbers of myofibroblasts, a heterogeneous cell population with varying capacities to promote repair.
MaryEllen R. Haas, Darlene V. Nguyen, Brett A. Shook   +2 more
doaj   +1 more source

miR-21 promotes the fibrotic properties in oral mucosa through targeting PDCD4

Journal of Dental Sciences, 2022
Background/purpose: Oral submucous fibrosis (OSF) has been regarded as a premalignant disorder of oral cancer, and myofibroblasts are the main cells that are responsible for pathological fibrosis.
Yi-Wen Liao, Lo-Lin Tsai, Yu-Hsien Lee, Pei-Ling Hsieh, Cheng-Chia Yu, Ming-Yi Lu   +5 more
doaj   +1 more source

Human esophageal myofibroblast secretion of bone morphogenetic proteins and GREMLIN1 and paracrine regulation of squamous epithelial growth

Scientific Reports, 2018
We have previously shown myofibroblasts subjacent to the squamous epithelium in the normal human esophagus and an increase in esophagitis. Myofibroblast contribution to bone morphogenetic protein (BMP) signaling and to paracrine mediated epithelial ...
Chunying Zhang, Chao Niu, Kevin Yang, Anisa Shaker   +3 more
doaj   +1 more source

Dexmedetomidine alleviates pulmonary fibrosis through the ADORA2B-Mediated MAPK signaling pathway

Respiratory Research, 2023
Background Idiopathic pulmonary fibrosis (IPF) is a chronically progressive fibrotic pulmonary disease characterized by an uncertain etiology, a poor prognosis, and a paucity of efficacious treatment options.
Xiaofan Lai, Yingying Lin, Shaojie Huang, Lvya Pu, Qihao Zeng, Zhongxing Wang, Wenqi Huang   +6 more
doaj   +1 more source

Endothelial Cells Expressing Endothelial and Mesenchymal Cell Gene Products in Lung Tissue From Patients With Systemic Sclerosis-Associated Interstitial Lung Disease. [PDF]

, 2016
OBJECTIVE: To examine whether lung endothelial cells (ECs) from patients with systemic sclerosis (SSc)-associated interstitial lung disease (ILD) express mesenchymal cell-specific proteins and gene transcripts, indicative of the occurrence of endothelial-
Arciniegas, Beon, Cooley, Del Galdo, Falke, Gabrielli, Gilbane, Good, Goumans, Hashimoto, Herzog, Herzog, Hinz, Hinz, Humphreys, Jimenez, Katsumoto, Kendall, Kramann, Lamouille, LeBleu, Li, Li, Marelli-Berg, Matucci-Cerinic, McAnulty, Medici, Meeteren, Nolan, Pattanaik, Piera-Velazquez, Piera-Velazquez, Poslethwaite, Ranchoux, Rieder, Strieter, Varga, Veraldi, Wells, Yoshimatsu, Zeisberg, Zeisberg   +41 more
core   +2 more sources

PDGF-AB Reduces Myofibroblast Differentiation Without Increasing Proliferation After Myocardial Infarction

JACC: Basic to Translational Science, 2023
Summary: After myocardial infarction (MI), fibroblasts progress from proliferative to myofibroblast states, resulting in fibrosis. Platelet-derived growth factors (PDGFs) are reported to induce fibroblast proliferation, myofibroblast differentiation, and
Robert D. Hume, PhD, Tejas Deshmukh, MBBS, MClinTR, Tram Doan, PhD, Woo Jun Shim, PhD, Shaan Kanagalingam, BSc, Vikram Tallapragada, PhD, Fairooj Rashid, MSc, Maria Marcuello, PhD, Daniel Blessing, PhD, Dinesh Selvakumar, MBBS, Kalyan Raguram, BMed, Faraz Pathan, MBBS, PhD, Dinny Graham, PhD, Samir Ounzain, PhD, Eddy Kizana, PhD, Richard P. Harvey, PhD, Nathan J. Palpant, PhD, James J.H. Chong, MBBS, PhD   +17 more
doaj   +1 more source

Growth factor restriction impedes progression of wound healing following cataract surgery: identification of VEGF as a putative therapeutic target [PDF]

, 2016
Secondary visual loss occurs in millions of patients due to a wound-healing response, known as posterior capsule opacification (PCO), following cataract surgery. An intraocular lens (IOL) is implanted into residual lens tissue, known as the capsular bag,
A Parenti, AJ Maloof, B Amoozgar, B Hinz, B Lundqvist, B Thylefors, BP Danysh, C Biagi, D Belotti, D Spalton, D Xu, G Duncan, G Duncan, GC Brown, IM Wormstone, IM Wormstone, IM Wormstone, IM Wormstone, IM Wormstone, J Nagata, JA Eldred, JA Eldred, JF Boyce, JL Davis, JL Kovach, K Hayashi, K Ohta, L Leishman, MA Nanavaty, N Ferrara, NI Chaudhary, NV Palejwala, O Nishi, PJ Sime, R Alon, RJ Kelly, RL Avery, RU de Iongh, S Resnikoff, SC Kavoussi, T Hara, T Hara, TM Rabsilber, W Wu, X Huang   +44 more
core   +1 more source