Results 101 to 110 of about 55,400 (275)

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Genomic Analysis of Inbreeding Depression on Productive Traits in Rubia Galega Beef Cattle Breed

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT In autochthonous livestock breeds with small populations, such as the Rubia Galega from Galicia (Spain), mating between relatives is common and can lead to inbreeding depression. Genomic inbreeding coefficients were estimated for 4984 animals using ~63,000 SNPs to assess inbreeding depression in four key traits: age at first calving (AFC) with
N. Mejuto‐Vázquez, C. Hervás‐Rivero, R. Rodríguez‐Bermúdez, D. López‐Carbonell, M. Hermida, P. Martínez, L. Varona   +6 more
wiley   +1 more source

Accumulation of muscle ankyrin repeat protein transcript reveals local activation of primary myotube endcompartments during muscle morphogenesis [PDF]

, 1997
The characteristic shapes and positions of each individual body muscle are established during the process of muscle morphogenesis in response to patterning information from the surrounding mesenchyme. Throughout muscle morphogenesis, primary myotubes are
Adams, Aigner, Arber, Arber, Arber, Ashby, Blank, Buckingham, Chevallier, Chien, Chiquet, Chu, Condon, Connor, deLapeyriére, Duxson, Fontaine, Gatchalian, Grayson, Hauschka, Hilfer, Imaizumi-Scherrer, Jellies, Lance-Jones, Lanser, McMahon, Olson, Ontell, Rechsteiner, Ross, Schaeren-Wiemers, Schroeter, Schroeter, Shaw, Sweeney, Tucker, Witzemann, Zou   +37 more
core   +3 more sources

Impact of obesity and an obesogenic environment on cardiotoxin‐induced damage and recovery of human myotubes

Experimental Physiology, EarlyView.
Abstract Obesity (BMI ≥ 30 kg/m2) reduces skeletal muscle quality and impairs the myogenic response to muscle damage. The present study investigated if differences exist in myotubes from individuals with (OB) or without (LN) obesity incubated in control (bovine serum albumin [BSA]) or obesogenic (Ob) medium, at baseline or in response to cardiotoxin ...
Brian P. Sullivan, Lundon C. Burton, Allison Ellis, Christopher K. Kargl, Deborah Shera, Shihuan Kuang, James F. Markworth, Timothy P. Gavin   +7 more
wiley   +1 more source

Prmt5 is a regulator of muscle stem cell expansion in adult mice. [PDF]

, 2015
Skeletal muscle stem cells (MuSC), also called satellite cells, are indispensable for maintenance and regeneration of adult skeletal muscles. Yet, a comprehensive picture of the regulatory events controlling the fate of MuSC is missing.
Braun, Thomas, Günther, Stefan, Kim, Johnny, Krüger, Marcus, Künne, Carsten, Looso, Mario, Zhang, Ting, Zhou, Yonggang   +7 more
core  

Impacts of exercise, renin–angiotensin system modulation or both on skeletal muscle circadian gene expression

Experimental Physiology, EarlyView.
Abstract Ageing negatively affects quality of life and healthspan, and interventions are needed to slow this progressive decline. Previously, we have demonstrated the potential functional benefits of combining a genetically modified probiotic (GMP) targeting the non‐canonical arm of the renin–angiotensin system (RAS) with exercise training.
Emily L. Zumbro, Liliana C. Baptista, Taylor Taylor, Abbi R. Hernandez, Anisha Banerjee, Yi Sun, YouFeng Yang, Qiuhong Li, Thomas W. Buford   +8 more
wiley   +1 more source

Microgravity‐induced changes in skeletal muscle and possible countermeasures: What we can learn from bed rest and human space studies

Experimental Physiology, EarlyView.
Abstract Despite exercise countermeasures to sustain health and performance in spaceflight, complete maintenance of muscle mass and functions in microgravity is still not possible for most astronauts. The principal cause of the limited effectiveness of existing exercise countermeasures is the difficulty in achieving full loading forces in space.
Alessandra Bosutti, Bergita Ganse, Nicola A. Maffiuletti, Rob C. I. Wüst, Gustav J. Strijkers, Andy Sanderson, Hans Degens   +6 more
wiley   +1 more source

Culture conditions influence satellite cell activation and survival of single myofibers [PDF]

, 2018
Single myofiber isolation protocols allow to obtain an in vitro system in which the physical association between the myofiber and its stem cells, the satellite cells, is adequately preserved.
Adamo, Sergio, Benedetti, Anna, Bouche', Marina, Moresi, Viviana, Renzini, Alessandra, Silvestroni, Leopoldo   +5 more
core   +2 more sources

OR27-01 Upregulated Prdm16 Impairs Adipogenesis And Promotes Myogenesis Via PAX7 And Osteogenesis In Testosterone-treated Hypogonadal Men [PDF]

, 2023
Siresha Bathina, Mia Prado, Lina Aguirre, Georgia Colleluori, Elliot Ballato, Fnu Deepika, Virginia Fuenmayor Lopez, Dennis T. Villareal, Reina Armamento Villareal   +8 more
openalex   +1 more source

Downregulation of microRNA‐494 drives mitochondrial biogenesis and function in trained muscle

Experimental Physiology, EarlyView.
Abstract MicroRNAs (miRNAs) are key regulators of cellular processes, including mitochondrial function and energy metabolism. This study explores the regulation of miR‐494 in skeletal muscle and circulation, investigating its response to exercise training and an acute exercise bout, its association with metabolic disorders, and the effects of ...
Natália Pálešová, Klára Gabrišová, Jana Babulicová, Patrik Krumpolec, Zuzana Kovaničová, Tímea Kurdiová, Salvatore Modica, Christian Wolfrum, Jozef Ukropec, Barbara Ukropcová, Miroslav Baláž   +10 more
wiley   +1 more source