Results 131 to 140 of about 53,888 (279)

Hes6 acts in a positive feedback loop with the neurogenins to promote neuronal differentiation [PDF]

open access: yes, 2000
During the development of the vertebrate nervous system, neurogenesis is promoted by proneural bHLH proteins such as the neurogenins, which act as potent transcriptional activators of neuronal differentiation genes.
Anderson­, David J.   +3 more
core  

Estrogen‐Related Receptor Alpha Promotes Skeletal Muscle Regeneration and Mitigates Muscular Dystrophy

open access: yesThe FASEB Journal, Volume 39, Issue 19, 15 October 2025.
ERRα promotes muscle regeneration. ERRα drives angiogenic and mitochondrial metabolic gene program in proliferating and differentiating myogenic cells. ERRα also induces myogenic factor genes such as MyoG. Through these pathways ERRα promotes muscle regeneration in the skeletal muscle in acute injury and chronic myopathy.
Thi Thu Hao Nguyen   +8 more
wiley   +1 more source

MuRF1 Partners With TRIM72 to Impair Insulin Signaling in Skeletal Muscle Cells

open access: yesThe FASEB Journal, Volume 39, Issue 19, 15 October 2025.
Insulin activates IRS1–Akt signaling to promote glucose uptake. Under dexamethasone treatment, MuRF1 stabilizes TRIM72, which decreases IRS1 protein abundance and impairs glucose uptake in skeletal muscle cells. ABSTRACT Muscle RING‐finger protein 1 (MuRF1, gene name: TRIM63) is well known as a critical molecular regulator in skeletal muscle atrophy ...
Ibrahim Musa   +3 more
wiley   +1 more source

Quantification of Myosin Heavy‐Chain mRNA during Myogenesis [PDF]

open access: bronze, 1978
Jeffrey Robbins, Stuart M. Heywood
openalex   +1 more source

Single‐Cell RNA Sequencing Reveals the Heterogeneity in Differentiation Trajectory and Tumor Microenvironment Leading to More Aggressive Phenotypes of Papillary Thyroid Cancer in Children and Young Adult Patients

open access: yesAdvanced Science, Volume 12, Issue 39, October 20, 2025.
scRNA sequencing reveals distinct tumor ecosystem features in CAYA‐PTC, marked by enriched CD4T_Tfh, CD8T_Tex cells, and rapid malignant thyrocyte differentiation (absent of mild‐state BRAF‐like population) toward invasive states. Prominent emCAF_LAMP5 populations interact with endothelial cells and thyrocytes facilitate angiogenesis and metastasis ...
Kai Guo   +15 more
wiley   +1 more source

Cell Proliferation and Fusion during Myogenesis in Culture [PDF]

open access: bronze, 1974
Mario Molinaro, M. Martinozzi, V. Monesi
openalex   +1 more source

Pancreatic Cancer‐Derived Extracellular Vesicles Enriched with miR‐223‐5p Promote Skeletal Muscle Wasting Associated with Cachexia

open access: yesAdvanced Science, Volume 12, Issue 37, October 6, 2025.
EVs and EV‐microRNAs (miRNAs) mediate PDAC‐skeletal muscle communication. miR‐223‐5p reduces METTL14 transcription by targeting MAFA, which subsequently decreases m6A methylation in skeletal muscles, ultimately leading to muscle wasting. This study highlights the absorption of miRNA in PDAC‐derived EVs by skeletal muscles and reveals a previously ...
Kangjing Xu   +7 more
wiley   +1 more source

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