Results 61 to 70 of about 53,888 (279)

Cell‐Delivering Injectable Hydrogels with Tunable Microporous Structures Improve Therapeutic Efficacy for Volumetric Muscle Loss

Advanced Functional Materials, EarlyView.
The study presents an injectable hydrogel with tunable microporosity to improve mesenchymal stem cell delivery for volumetric muscle loss treatment. Mesenchymal stem cells encapsulated in porous hydrogels significantly promote the spreading, proliferation, and cytokine secretion of mesenchymal stem cells.
Hana Yasue, Tetsushi Taguchi, Taka‐Aki Asoh, Akihiro Nishiguchi   +3 more
wiley   +1 more source

myomiR-dependent switching of BAF60 variant incorporation into Brg1 chromatin remodeling complexes during embryo myogenesis [PDF]

, 2014
Myogenesis involves the stable commitment of progenitor cells followed by the execution of myogenic differentiation, processes that are coordinated by myogenic regulatory factors, microRNAs and BAF chromatin remodeling complexes.
Bajard, Bartel, Buckingham, Béthune, Chen, Chen, Darnell, de la Serna, de la Serna, Ebert, Forcales, Goljanek-Whysall, Goljanek-Whysall, Goljanek-Whysall, Gros, Hamburger, Hirai, Ho, Hornstein, Ivey, Kadam, Krützfeldt, Lamba, Lessard, Lickert, Liu, Liu, Loeb, Mallappa, Mann, McCarthy, McGlinn, Mishima, Mok, Ochi, Puri, Rao, Rosenberg, Saccone, Simone, Sohni, Stark, Sweetman, Sweetman, Takeuchi, van Rooij, Wang, Williams, Williams, Wu, Yoo, Yoo, Zhao   +52 more
core   +1 more source

Cell Surface Thiol Engineering Mechanoregulates Myogenic Differentiation via the FAK–PI3K–AKT Axis

Advanced Healthcare Materials, EarlyView.
Schematic diagram illustrating how cell surface modification of skeletal muscle progenitor cells through TCEP treatment reveals enhanced cell adhesion, intracellular tension, and myogenesis at 19.66 kPa stiffness, leading to optimal cell fusion. In contrast, no significant changes are observed in the softer (10.61 kPa) or stiffer (49.4 kPa) matrices ...
Juyeon Kim, Sung Sik Hur, Jae Hong Park, Myung Jin Ban, Jin‐Young Kim, Joo Hyun Kim, Ji Hyae Choo, Hae‐Won Kim, Ju Hun Lee, Man Ryul Lee, Yongsung Hwang   +10 more
wiley   +1 more source

The ESCRT-0 subcomplex component Hrs/Hgs is a master regulator of myogenesis via modulation of signaling and degradation pathways

BMC Biology, 2021
Background Myogenesis is a highly regulated process ending with the formation of myotubes, the precursors of skeletal muscle fibers. Differentiation of myoblasts into myotubes is controlled by myogenic regulatory factors (MRFs) that act as terminal ...
L. Coudert, A. Osseni, Y. G. Gangloff, L. Schaeffer, P. Leblanc   +4 more
doaj   +1 more source

Retinoic Acid Signaling Plays a Crucial Role in Excessive Caffeine Intake-Disturbed Apoptosis and Differentiation of Myogenic Progenitors

Frontiers in Cell and Developmental Biology, 2021
Whether or not the process of somitogenesis and myogenesis is affected by excessive caffeine intake still remains ambiguous. In this study, we first showed that caffeine treatment results in chest wall deformities and simultaneously reduced mRNA ...
Nian Wu, Nian Wu, Yingshi Li, Xiangyue He, Xiangyue He, Jiayi Lin, Denglu Long, Xin Cheng, Beate Brand-Saberi, Guang Wang, Guang Wang, Xuesong Yang, Xuesong Yang   +12 more
doaj   +1 more source

Post-transcriptional regulation of satellite cell quiescence by TTP-mediated mRNA decay. [PDF]

, 2015
Skeletal muscle satellite cells in their niche are quiescent and upon muscle injury, exit quiescence, proliferate to repair muscle tissue, and self-renew to replenish the satellite cell population.
Blackshear, Perry J, Cadwallader, Adam B, Clement, Sandra L, Doles, Jason D, Hall, Monica N, Hausburg, Melissa A, Lykke-Andersen, Jens, Olwin, Bradley B   +7 more
core   +2 more sources

Geometrically Tunable Scaffold‐Free Muscle Bioconstructs for Treating Volumetric Muscle Loss

Advanced Healthcare Materials, EarlyView.
Volumetric muscle loss is associated with traumatic muscle resulting in permanent functional impairment. Mold‐based, scaffold‐free, high‐density muscle tissue bioconstructs are developed in customizable geometric shapes and sizes. The transplanted rectangular solid‐shaped muscle bioconstructs improved muscle force recovery and tissue regeneration in ...
Bugra Ayan, Gaoxian Chen, Ishita Jain, Sha Chen, Gladys Chiang, Caroline Hu, Renato Reyes, Beu P. Oropeza, Ngan F. Huang   +8 more
wiley   +1 more source

Farewell to Professor David Yaffe – A Pillar of the Myogenesis Field

European Journal of Translational Myology, 2020
It is with great sadness that we have learned about the passing of Professor David Yaffe (1929-2020, Israel). Yehi Zichro Baruch - May his memory be a blessing. David was a man of family, science and nature.
Zipora Yablonka-Reuveni, Frank Stockdale, Uri Nudel, David Israeli, Helen M. Blau, Asher Shainberg, Sara Neuman, Gania Kessler-Icekson, Erica Meghid Krull, Bruce Paterson, Ora Saxel Fuchs, David Greenberg, Rachel Sarig, Orna Halevy, Eijiro Ozawa, Don J. Katcoff   +15 more
doaj   +1 more source

Overlapping functions of SIX homeoproteins during embryonic myogenesis.

PLoS Genetics, 2023
Four SIX homeoproteins display a combinatorial expression throughout embryonic developmental myogenesis and they modulate the expression of the myogenic regulatory factors.
Maud Wurmser, Rouba Madani, Nathalie Chaverot, Stéphanie Backer, Matthew Borok, Matthieu Dos Santos, Glenda Comai, Shahragim Tajbakhsh, Frédéric Relaix, Marc Santolini, Ramkumar Sambasivan, Rulang Jiang, Pascal Maire   +12 more
doaj   +1 more source

DNMT3B in vitro knocking-down is able to reverse embryonal rhabdomyosarcoma cell phenotype through inhibition of proliferation and induction of myogenic differentiation [PDF]

, 2016
Aberrant DNA methylation has been frequently observed in many human cancers, including rhabdomyosarcoma (RMS), the most common soft tissue sarcoma in children.
Camero, Simona, Ceccarelli, Simona, Clerico, Anna, Dominici, Carlo, Mannarino, Olga, Marampon, Francesco, Marchese, Cinzia, Mcdowell, Heather P, Megiorni, Francesca, Pizer, Barry, Pizzuti, Antonio, Shukla, Rajeev   +11 more
core   +1 more source