Results 91 to 100 of about 380,707 (403)

Hypertrophic cardiomyopathy and the myosin mesa: viewing an old disease in a new light

Biophysical Reviews, 2017
The sarcomere is an exquisitely designed apparatus that is capable of generating force, which in the case of the heart results in the pumping of blood throughout the body.
Darshan V. Trivedi, A. Adhikari, Saswata S. Sarkar, K. Ruppel, J. Spudich   +4 more
semanticscholar   +1 more source

Geometrically Tunable Scaffold‐Free Muscle Bioconstructs for Treating Volumetric Muscle Loss

Advanced Healthcare Materials, EarlyView.
Volumetric muscle loss is associated with traumatic muscle resulting in permanent functional impairment. Mold‐based, scaffold‐free, high‐density muscle tissue bioconstructs are developed in customizable geometric shapes and sizes. The transplanted rectangular solid‐shaped muscle bioconstructs improved muscle force recovery and tissue regeneration in ...
Bugra Ayan, Gaoxian Chen, Ishita Jain, Sha Chen, Gladys Chiang, Caroline Hu, Renato Reyes, Beu P. Oropeza, Ngan F. Huang   +8 more
wiley   +1 more source

Myosin VI Rewrites the Rules for Myosin Motors [PDF]

Cell, 2010
Myosin VI is the only type of myosin motor known to move toward the minus ends of actin filaments. This reversal in the direction of its movement is in part a consequence of the repositioning of its lever arm. In addition, myosin VI has a number of other specialized structural and functional adaptations that optimize performance of its unique cellular ...
Sweeney, H. Lee, Houdusse, Anne
openaire   +2 more sources

ROS‐Triggered Microgels for Programmable Drug Release in Volumetric Muscle Loss Repair

Advanced Healthcare Materials, EarlyView.
Reduced graphene oxide‐incorporated hyaluronic acid microgels are developed as ROS‐responsive, injectable platforms for curcumin delivery in volumetric muscle loss. The microgels exhibit strong antioxidative activity, high drug‐loading capacity, and ROS‐triggered release.
Seungjun Lee, Goeun Choe, Junghyun Kim, Junggeon Park, Jia Yi Erica Kok, Jae Young Lee   +5 more
wiley   +1 more source

Granular Hydrogels as Modular Biomaterials: From Structural Design to Biological Responses

Advanced Healthcare Materials, EarlyView.
Granular hydrogels are now emerging as promising biomaterials due to their inherent microporousity, injectability, and modularity. They have shown improvements in cell viability and migration, cellular/tissue infiltration, host tissue integration, mitigated foreign body response, and tissue regeneration.
Asmasadat Vaziri, Renata Maia, Pei Zhang, Liliana Agresti, Jelmer Sjollema, Mohammad‐Ali Shahbazi, Hélder A. Santos   +6 more
wiley   +1 more source

Multidimensional structure-function relationships in human β-cardiac myosin from population-scale genetic variation

Proceedings of the National Academy of Sciences of the United States of America, 2016
Significance Genetic variants in human β-cardiac myosin, which causes muscle contraction in the heart, can lead to hypertrophic cardiomyopathy (HCM), an inherited heart disease that can cause sudden death.
J. Homburger, Eric M. Green, C. Caleshu, Margaret S. Sunitha, Rebecca E. Taylor, K. Ruppel, Raghu Metpally, S. Colan, M. Michels, S. Day, I. Olivotto, C. Bustamante, F. Dewey, Carolyn Y. Ho, J. Spudich, E. Ashley   +15 more
semanticscholar   +1 more source

Calcium-independent contraction in lysed cell models of teleost retinal cones: activation by unregulated myosin light chain kinase or high magnesium and loss of cAMP inhibition. [PDF]

, 1987
The retinal cones of teleost fish contract at dawn and elongate at dusk. We have previously reported that we can selectively induce detergent-lysed models of cones to undergo either reactivated contraction or reactivated elongation, with rates and ...
Ackland, N, Burnside, B
core  

Internal Motility in Stiffening Actin-Myosin Networks

, 2003
We present a study on filamentous actin solutions containing heavy meromyosin subfragments of myosin II motor molecules. We focus on the viscoelastic phase behavior and internal dynamics of such networks during ATP depletion.
A. G. Weeds, C. F. Schmidt, D. Wachsstock, F. G. Schmidt, J. A. Spudich, J. Howard, P. Detmers, S. J. Kron, S. J. Kron, S. S. Margossian, T. Nishizaka   +10 more
core   +1 more source

Global morphogenetic flow is accurately predicted by the spatial distribution of myosin motors. [PDF]

, 2018
During embryogenesis tissue layers undergo morphogenetic flow rearranging and folding into specific shapes. While developmental biology has identified key genes and local cellular processes, global coordination of tissue remodeling at the organ scale ...
Lefebvre, Matthew F, Noll, Nicholas, Shraiman, Boris I, Streichan, Sebastian J, Wieschaus, Eric F   +4 more
core   +2 more sources

A Microphysiological Interface of Skeletal Myobundles and Inflamed Adipose Tissue for Recapitulating Muscle Dysfunction in an Obese Microenvironment

Advanced Healthcare Materials, EarlyView.
A human cell‐based microphysiological system integrates engineered muscle tissues with an inflamed adipose–macrophage niche to model obese microenvironment‐induced muscle dysfunction. Muscle contraction is quantified by pillar deflection coupled with computational stiffness estimation. Secretome and transcriptomic profiling reveal inflammation‐mediated
Seunggyu Kim, Tianxin Cao, Zhengpeng Wan, Jaesang Kim, Zhuxuan Li, Legairre A. Radden II, Rakesh Santhanam, Eunkyung Clare Ko, Tatsuya Osaki, Sarah Spitz, Hyunmin Moon, Maria Proestaki, Seokbeom Roh, Gyudo Lee, Jessie S. Jeon, Curtis R. Warren, Roger D. Kamm   +16 more
wiley   +1 more source