Results 81 to 90 of about 199,830 (310)

Chemical Screening Identifies Danofloxacin as a Self‐Renewal Agonist of Embryonic Stem Cells through Alleviation of HDAC1‐Mediated Deacetylation of Tert and Prdm10

Advanced Science, EarlyView.
This study identified Danofloxacin as a novel supporter of the maintenance of mouse embryonic stem cell (ESC) pluripotency. It functions partially by inhibiting HDAC1, which increases specific histone acetylation marks and activates key genes like Tert and Prdm10.
Yan Zhang, Junxiang Ji, Baoxing Dong, Zhenhua Zhu, Xucheng Lv, Peng Chen, Wenqiang Liu, Min Zhou, Shou‐Dong Ye   +8 more
wiley   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Myosin-X and myosin-XIX in intracellular transport [PDF]

, 2010
Myosin motor proteins travel along actin filaments and power the movements responsible for force generation, vesicle and organelle trafficking, and formation of protrusive cellular structures. This dissertation discusses myosin‐X and the novel myosin‐XIX.
DiVito, Melinda M.
core   +1 more source

CNTN2 Deficiency Disrupts Ascending Auditory Neuroglial Interactions and Redox Homeostasis in Neural Presbycusis

Advanced Science, EarlyView.
. ABSTRACT Neural presbycusis disrupts auditory timing and speech perception, yet its molecular basis remains poorly understood. This study identifies Cntn2 as the Ranvier's nodal molecule significantly downregulated in aged auditory nerves. Cntn2 heterozygous knockout (Cntn2+/−) mice showed elevated auditory brainstem response thresholds and prolonged
Penghui Chen, Jingyi Zhu, Sihan Huang, Beibei Xu, Maoli Duan, Jingrong Lv, Jiarui Chen, Jun Yang, Shule Hou   +8 more
wiley   +1 more source

SE-HPLC separation of myosin complex with tannins from bearberries (Arctostaphylos uva-ursi L. Sprengel) leaves - a short report.

Czech Journal of Food Sciences, 2009
Phenolic compounds were extracted from bearberry (Arctostaphylos uva-ursi L. Sprengel) leaves into 95% (v/v) ethanol. The tannin constituents were separated from the crude extract using Sephadex LH-20 column chromatography with 95% (v/v) ethanol and 50% (
Ryszard Amarowicz, Ronald B. Pegg, Agnieszka Kosińska   +2 more
doaj   +1 more source

Molecular analysis of the myosin gene family in Arabidopsis thaliana [PDF]

, 1994
Myosin is believed to act as the molecular motor for many actin-based motility processes in eukaryotes. It is becoming apparent that a single species may possess multiple myosin isoforms, and at least seven distinct classes of myosin have been identified
Kinkema, Mark, Schiefelbein, John W., Schiefelbein, John, Wang, Haiyang   +3 more
core   +2 more sources

Deciphering Anti‐Cancer Drug Efficacy Through Nanomechanical Vibrations in Living Gastric Cancer Organoids

Advanced Science, EarlyView.
This study developed an efficacy assessment platform that integrates patient‐derived gastric cancer organoids, atomic force microscopy (AFM)‐based nanomechanical vibration detection, deep learning analysis, and organoid mechanical modeling. It detects picomolar drug effects within 0.1 s signal, achieves 97% classification accuracy, and offers non ...
Ting Zhang, Qiubo Chen, Shihai Lan, Liang Zhu, Shuaiyu Liu, Yan Xia, Yalu Zhang, Hanhui Yao, Yongman Liu, Shangquan Wu, Qingchuan Zhang   +10 more
wiley   +1 more source

Loss of LCN2 Function Ameliorates Glucocorticoid‐Induced Muscle Atrophy via Remodeling the Extracellular Matrix

Advanced Science, EarlyView.
Glucocorticoids transcriptionally activate LCN2 expression via GR nuclear translocation. Secreted LCN2 binds MMP9 to degrade skeletal muscle ECM collagen, blocks integrin‐mediated mechanotransduction, bidirectionally disrupts muscle protein homeostasis, and reveals a novel target for steroid‐induced muscle atrophy.
Hongwei Shi, Xiaojing Hao, Yi Yan, Fengyang Li, Yaru Zhang, Zixin Li, Wenjuan Xie, Jiayin Lu, Xiaomao Luo, Yanjun Dong, Haidong Wang, Juan Wang   +11 more
wiley   +1 more source

A Microenvironment‐Adaptive Scaffold Rejuvenates Peripheral Nerve Regeneration During Aging Via Dual Modulation of Ferroptotic Stimuli in Schwann Cells

Advanced Science, EarlyView.
(i) Aging impairs peripheral nerve regeneration via its dual ferroptosis‐mediated pathologies in senescent schwann cells. (ii) The composite nerve conduit is a symbiosis niche integrating microenvironment‐responsive nanoparticles (Ga‐PTAs) and maxillofacial‐derived mesenchymal stem cells (Mmscs).
Ning Zhan, Lixin Tian, Lianjie Peng, Jingyu Zhang, Lining Lin, Xiaoting Zhang, Yaxian Luo, Zhichao Liu, Xinhua Yao, Mouyuan Sun, Yong He, Mengfei Yu, Huiming Wang   +12 more
wiley   +1 more source

Lack of replication for the myosin-18B association with mathematical ability in independent cohorts [PDF]

, 2015
Twin studies indicate that dyscalculia (or mathematical disability) is caused partly by a genetic component, which is yet to be understood at the molecular level.
Cowie, H., Paracchini, S., Watson, J., Hennessy, E. R., Nudel, R., Seckl, J., Dworzynski, K., Whitehouse, A. J O, Fisher, S. E., Bolton, P. F., Simkin, Z., Bishop, D. V.M., Thompson, P., Pettigrew, K. A., Newbury, D. F., Hayiou-Thomas, M. E., O'Hare, A., Baird, G., Wang, C., Conti, G., Clark, A., Bishop, D. V M, Snowling, M. J., Whitehouse, A. J.O., Fajutrao Valles, S. F., Helms, P. J., Ramsden, D., Simonoff, E.; id_orcid, Nasir, J., Monaco, A. P., Francks, C., Slonims, V., Moll, K., Simpson, N. H., Pennell, C., Leavett, R., Thompson, P.; id_orcid, Pickles, A., Everitt, A., Shaw, D., Simonoff, E., The SLI Consortium, SLI Consortium, Ring, S., Northstone, K., Cohen, W., Pettigrew, Kerry A, Fisher, S E, Simpson, N., S. E. Fisher, K. Northstone, N. H. Simpson, Newbury, D., S. Paracchini, S. Ring, M. E. Hayiou‐Thomas, M. J. Snowling, Hayiou-Thomas, M.E., Whitehouse, A., Newbury, D.F., Ring, S, C. Pennell, Fajutrao Valles, S., Clark, Ann, Pennell, C, Simpson, Nuala H, Northstone, K, D. F. Newbury, Snowling, M J, Newbury, D F, Wang, C, Pettigrew, K.A., Moll, Kristina, Fisher, S.E., S. F. Fajutrao Valles, Northstone, Kate, Paracchini, S, R. Leavett, C. Wang, Fajutrao-Valles, S. F., Whitehouse, A J O, Leavett, Ruth, Snowling, Margaret J, Hayiou-Thomas, M., Newbury, Dianne F, Wang, Carol, Consortium, S.L.I., Ring, Susan, Simpson, N H, Whitehouse, A. J. O., Fajutrao Valles, S F, Leavett, R, Moll, K, Fajutrao Valles, Samuelle F, K. A. Pettigrew, Hayiou-Thomas, M E, Whitehouse, Andrew J O, Thompson, Paul, K. Moll, Simpson, N.H., ?, ?, Whitehouse, A.J.O., Pettigrew, K A, A. J. O. Whitehouse, Hayiou-Thomas, Marianna E, Paracchini, Silvia, Snowling, M.J., Thompson, Paul A., Pettigrew, K., SLI Consortium, P. Thompson, Fisher, Simon E, Fisher, S., Pennell, Craig, Valles, S.F.F., Snowling, M., Watson, Jocelynne, Thompson, P, Paracchini, Silvia; id_orcid   +117 more
core   +1 more source