Results 81 to 90 of about 181,791 (317)

Enhancing Maturation of Human Neuromuscular Organoids via Electrical Stimulation

Advanced Science, EarlyView.
A framework for on‐demand and non‐invasive exposure of human neuromuscular organoids (NMOs) to electrical stimuli is established to promote their maturation. The robustness and effectiveness of different stimulation regimes are evaluated via thorough characterization of organoid tissue structure and contraction capacity. Chronic electrical stimulation,
Chrysanthi‐Maria Moysidou, Inês Afonso Martins, Ismail Amr El‐Shimy, Iacopo Bicci, Donatella Cea, Christina Bukas, Isra Mekki, Mara‐Camelia Rusu, Aylin Nebol, Ines Lahmann, Marie Piraud, Enrico Klotzsch, Mina Gouti   +12 more
wiley   +1 more source

Tyrosine phosphorylation of myosin heavy chain during skeletal muscle differentiation: an integrated bioinformatics approach

, 2005
Background: Previously it has been shown that insulin-mediated tyrosine phosphorylation of myosin heavy chain is concomitant with enhanced association of C-terminal SRC kinase during skeletal muscle differentiation. We sought to identify putative site(s)
RJ Edwards, Harney, D.F., Richard J. Edwards (7949342), DF Harney, Ryan K. Butler (7949339), Donal F. Harney (7949336), Butler, R., Edwards, Richard J., RK Butler   +8 more
core   +1 more source

Lack of replication for the myosin-18B association with mathematical ability in independent cohorts [PDF]

, 2015
SP is a Royal Society University Research Fellow. This specific study in the ALSPAC cohort was supported by a MRC grant to SP [grant number G0800523/8647].
Newbury, Dianne F, Pettigrew, Kerry A, Wang, Carol, Paracchini, S., Fisher, S E, Consortium, S.L.I., Simpson, N., Fisher, S. E., S. E. Fisher, Ring, Susan, Simpson, N H, K. Northstone, N. H. Simpson, Newbury, D., S. Paracchini, Whitehouse, A. J. O., Fajutrao Valles, S F, Leavett, R, S. Ring, Moll, K, Snowling, M. J., Fajutrao Valles, S. F., M. E. Hayiou‐Thomas, M. J. Snowling, Fajutrao Valles, Samuelle F, Hayiou-Thomas, M.E., K. A. Pettigrew, Hayiou-Thomas, M E, Whitehouse, Andrew J O, Whitehouse, A., Thompson, Paul, Newbury, D.F., Moll, K., K. Moll, Ring, S, Simpson, N. H., C. Pennell, Simpson, N.H., Leavett, R., ?, ?, Whitehouse, A.J.O., Pettigrew, K A, Fajutrao Valles, S., Clark, Ann, Northstone, K., Pennell, C, A. J. O. Whitehouse, Hayiou-Thomas, Marianna E, Paracchini, Silvia, Simpson, Nuala H, Snowling, M.J., Northstone, K, D. F. Newbury, Snowling, M J, Newbury, D F, Thompson, P., Pettigrew, K. A., Wang, C, Newbury, D. F., Pettigrew, K.A., Hayiou-Thomas, M. E., Thompson, Paul A., Pettigrew, K., Wang, C., SLI Consortium, P. Thompson, Moll, Kristina, Fisher, Simon E, Fisher, S.E., S. F. Fajutrao Valles, Fisher, S., Northstone, Kate, Pennell, Craig, Paracchini, S, Valles, S.F.F., Snowling, M., R. Leavett, Pennell, C., Watson, Jocelynne, C. Wang, Fajutrao-Valles, S. F., Whitehouse, A J O, Leavett, Ruth, Snowling, Margaret J, Thompson, P, Ring, S., Hayiou-Thomas, M.   +86 more
core   +1 more source

BIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow‐Transit Constipation

Advanced Science, EarlyView.
Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu, Hao Zhang, Wenhao Qiao, Ran Liu, Jie Sun, Xiaopei Li, Qin Li, Dongbo Zhao, Dawei Chen, Jingxin Li, Shuxiao Dong   +10 more
wiley   +1 more source

Shaking the myosin family tree: Biochemical kinetics defines four types of myosin motor

, 2011
Although all myosin motors follow the same basic cross-bridge cycle, they display a large variety in the rates of transition between different states in the cycle, allowing each myosin to be finely tuned for a specific task.
Bloemink, Marieke J., Geeves, M., Bloemink, M., Geeves, Michael A., Marieke J. Bloemink, Michael A. Geeves   +5 more
core   +1 more source

Diminished climing fiber innervation of Purkinje cells in the cerebellum of myosin Va mutant mice and rats [PDF]

, 2007
Myosin Va is an actin-based molecular motor that is involved in organelle transport and membrane trafficking. Here, we explored the role of myosin Va in the formation of synaptic circuitry by examining climbing fiber (CF) innervation of Purkinje cells ...
Otsuka, Hiroyuki, Murata, Yoshiharu, Takagishi, Yoshiko, Hashimoto, Kouichi, Mizoguchi, Akira, Kayahara, Tetsuro, Kano, Masanobu, Watanabe, Masahiko   +7 more
core   +1 more source

SE-HPLC separation of myosin complex with tannins from bearberries (Arctostaphylos uva-ursi L. Sprengel) leaves - a short report.

Czech Journal of Food Sciences, 2009
Phenolic compounds were extracted from bearberry (Arctostaphylos uva-ursi L. Sprengel) leaves into 95% (v/v) ethanol. The tannin constituents were separated from the crude extract using Sephadex LH-20 column chromatography with 95% (v/v) ethanol and 50% (
Ryszard Amarowicz, Ronald B. Pegg, Agnieszka Kosińska   +2 more
doaj   +1 more source

Multi‐Omics Insights Into the Mechanisms of Early Muscle Fiber Difference and Transformation Between Lean‐Type and Chinese Indigenous Pigs

Advanced Science, EarlyView.
Multi‐omics analyses uncover breed‐specific cis‐regulatory landscapes and higher‐order chromatin architectural differences that underlie early postnatal muscle fiber divergence in pigs. A super‐enhancer upstream of PPP3CB recruits MEF2C to activate PPP3CB transcription, while the PPP3CB–MEF2C positive feedback loop promotes oxidative muscle fiber ...
Shuailong Zheng, Hainan Wu, Min Liu, Kunpeng Wu, Shuntao Huang, Zulfiqar Ahmed, Lenox Pius, Mengjin Zhu, Dequan Xu   +8 more
wiley   +1 more source

Lactation is Associated with Accelerated Postpartum Pelvic Floor Muscle Recovery in a Pregnant Simulated Birth Injury Model

Advanced Science, EarlyView.
ABSTRACT Healthy pelvic floor muscles (PFMs) are essential for proper pelvic floor function. The biggest risk factor for PFM dysfunction is injury sustained during vaginal childbirth, yet the factors that facilitate or impair PFM recovery from birth injury remain unknown.
Bianca L. Peña, Khushi M. Diwakar, Hillary K. Tran, Selena Cao, Celeste E. Lintz, Laila N. Hayes, Marianna Alperin, Karen L. Christman   +7 more
wiley   +1 more source

Structure and Function of Myosin Isoforms in Adult Chicken Hindlimb Muscles [PDF]

, 2002
Although large accumulation of sequence data is published for a variety of myosin heavy chain (MHC) isoforms, the meaning of heterogeneity among the amino acid sequences remains unclear as to the key contractile and biochemical properties of muscle ...
Higashiyama, Yasuhito, Maita, Tetsuo, Nakayama, Susumu, Ohki, Takashi, Yamaguchi, Taku, Miyanishi, Takayuki, Hayashibara, Toshihisa, Aso, Hiroki, Yajima, Eiko   +8 more
core