FEBS Open Bio, EarlyView.KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph +7 more
wiley +1 more source
Myosin-II and cytosolic mCherry during migration under microfluidic confinement.
, 2016 (A) Myosin-II accumulates at the cortex in confined Dictyostelium cells, while (B) mCherry, used as a volume marker, does not show cortical/membrane enrichment at 1.7 μm.
Zachary R. Gagnon (3196320) +3 more
core +1 more source
FEBS Open Bio, EarlyView.The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen +8 more
wiley +1 more source
The role of myosin II in stabilizing actin tethers promoting GLUT4 exocytosis in 3T3-L1 adipocytes [PDF]
, 2018 Aberrant insulin signaling results in an impaired ability to clear glucose from the bloodstream, which progresses to type II diabetes mellitus once insulin stimulation no longer results in a significant decrease in blood glucose levels.
Nikouyeh, Jonah B. +1 more
core
Shaking the myosin family tree: Biochemical kinetics defines four types of myosin motor
, 2011 Although all myosin motors follow the same basic cross-bridge cycle, they display a large variety in the rates of transition between different states in the cycle, allowing each myosin to be finely tuned for a specific task.
Bloemink, Marieke J. +5 more
core +1 more source
Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach +23 more
wiley +1 more source
Localization of Myosin II and identification of its potential upstream regulators in Dictyostelium discoideum [PDF]
, 2015 The thesis work presented here aimed to understand how myosin II is regulated in Dictyostelium discoideum within the context of chemotactic signaling and cell migration.
Herring, Ashley +1 more
core
Tyrosine phosphorylation of myosin heavy chain during skeletal muscle differentiation: an integrated bioinformatics approach [PDF]
, 2005 Background: Previously it has been shown that insulin-mediated tyrosine phosphorylation of myosin heavy chain is concomitant with enhanced association of C-terminal SRC kinase during skeletal muscle differentiation. We sought to identify putative site(s)
RJ Edwards +8 more
core +1 more source
Biohybrid Crawling Robot With Spiral‐Spring Backbone and Inclined Legs for Enhanced Locomotion
Advanced Materials, EarlyView.We present a biohybrid crawling robot integrating a muscle ring with a flexible skeleton combining two complementary structural elements. The spiral‐spring backbone enables large‐amplitude bending without compromising axial stability, while outward‐inclined legs with unequal front–rear lengths effectively convert deformation into directional strides ...
Tomohiro Morita +2 more
wiley +1 more source
Ablation of smooth muscle myosin heavy chain SM2 increases smooth muscle contractility and results in postnatal death in mice [PDF]
, 2008 The smooth muscle myosin heavy chains (SMHC) are motor proteins powering smooth muscle contraction. Alternate splicing of SHMC gene at the C-terminus produces SM1, and SM2 myosin isoforms; SM2 (200 kDa) contains a unique 9-amino-acid sequence at the ...
Mei Chi +4 more
core