Results 51 to 60 of about 282,889 (299)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

An expanded role of the SNARE-containing regulon as it relates to the defense process that Glycine max has to Heterodera glycines

Journal of Plant Interactions, 2019
The defense regulon has been defined genetically in Arabidopsis thaliana to involve the syntaxin PENETRATION1 (PEN1), the secreted glucosidase (PEN2) and an ATP-binding cassette (ABC) transporter (PEN3).
Hannah W. Austin, Brant T. McNeece, Keshav Sharma, Prakash M. Niraula, Katherine S. Lawrence, Vincent P. Klink   +5 more
doaj   +1 more source

Drosophila non-muscle myosin II motor activity determines the rate of tissue folding

eLife, 2016
Non-muscle cell contractility is critical for tissues to adopt shape changes. Although, the non-muscle myosin II holoenzyme (myosin) is a molecular motor that powers contraction of actin cytoskeleton networks, recent studies have questioned the ...
Claudia G Vasquez, Sarah M Heissler, Neil Billington, James R Sellers, Adam C Martin   +4 more
doaj   +1 more source

Myosin light chain kinase is not a regulator of synaptic vesicle trafficking during repetitive exocytosis in cultured hippocampal neurons [PDF]

, 2006
The mechanism by which synaptic vesicles (SVs) are recruited to the release site is poorly understood. One candidate mechanism for trafficking of SVs is the myosin-actin motor system.
Goda, Y, Tokuoka, H
core   +1 more source

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

Myosin VIII associates with microtubule ends and together with actin plays a role in guiding plant cell division

eLife, 2014
Plant cells divide using the phragmoplast, a microtubule-based structure that directs vesicles secretion to the nascent cell plate. The phragmoplast forms at the cell center and expands to reach a specified site at the cell periphery, tens or hundreds of
Shu-Zon Wu, Magdalena Bezanilla
doaj   +1 more source

Structures of smooth muscle myosin and heavy meromyosin in the folded, shutdown state [PDF]

, 2007
Remodelling of the contractile apparatus within smooth muscle cells is an essential process that allows effective contractile activity over a wide range of cell lengths.
Ankrett, Burgess, Burgess, Burgess, Craig, Craig, Cremo, Cross, Dominguez, Elliott, Elliott, Frank, Fraser, Frederiksen, Gourinath, Houdusse, Hvidt, Ikebe, Joseph M. Chalovich, Knight, Knight, Lauzon, Liu, Matt L. Walker, Mazhari, Offer, Offer, Offer, Olney, Onishi, Onishi, Penczek, Persechini, Peter J. Knight, Quinlan, Rayment, Rhoda J. Hawkins, Rimm, Salzameda, Sellers, Seow, Sheng, Shuizi Yu, Sobieszek, Stafford, Stan A. Burgess, Suzuki, Tama, Thirumurugan, Tonino, Trybus, Trybus, Trybus, Trybus, Wahlstrom, Walker, Wendt, Wendt, Woodhead, Wu, Yanagisawa   +60 more
core   +1 more source

3D (Bio) Printing Combined Fiber Fabrication Methods for Tissue Engineering Applications: Possibilities and Limitations

Advanced Functional Materials, EarlyView.
Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana, Indra Apsite, Leonid Ionov   +2 more
wiley   +1 more source

Preparación de genotecas de ADNc de Plasmodium falciparum para la búsqueda de los genes de proteínas de unión a calmodulina, GOGAT y Pfmyo A.

Biomédica: revista del Instituto Nacional de Salud, 2002
Se construyó una genoteca de ADNc representativa de los estadios asexuales de Plasmodium falciparum, en el vector lZipLox. Esta genoteca (de la cepa colombiana FCB2) y otra genoteca construida en lZAP II (de la cepa Dd2), se rastrearon en busca de genes ...
Dary L. Mendoza, Moisés Wasserman
doaj   +1 more source

Prolonged function and optimization of actomyosin motility for upscaled network-based biocomputation

New Journal of Physics, 2021
Significant advancements have been made towards exploitation of naturally available molecular motors and their associated cytoskeletal filaments in nanotechnological applications. For instance, myosin motors and actin filaments from muscle have been used
Aseem Salhotra, Jingyuan Zhu, Pradheebha Surendiran, Christoph Robert Meinecke, Roman Lyttleton, Marko Ušaj, Frida W Lindberg, Marlene Norrby, Heiner Linke, Alf Månsson   +9 more
doaj   +1 more source