Results 101 to 110 of about 196,791 (307)

Tumor Mechanical Remodeling via Bidirectional Calcium Redistribution Enables Deep Photothermal‐Immunotherapy

Advanced Science, EarlyView.
A bidirectional calcium‑redistributing nanomodulator rewires intra‑extracellular calcium homeostasis to remodel tumor mechanical microenvironments. It softens tumor stroma to facilitate deep tissue penetration while stiffening tumor cells, evoking amplified immunogenic cell death and robust CTL infiltration, which achieves potent deep photothermal ...
Hongjuan Zhao, Jinpei Sun, Chenxi Zhao, Yuting Cang, Keyu Zong, Yuxin Guo, Yajing Wang, Di Meng, Qingling Song, Lei Wang   +9 more
wiley   +1 more source

Familial Hypertrophic Cardiomyopathy: Diagnosis and Management

Vascular Health and Risk Management, 2023
Michael J Litt,1 Ayan Ali,2 Nosheen Reza1 1Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; 2Department of Medicine, Perelman School of Medicine at the ...
Litt MJ, Ali A, Reza N
doaj  

Rapid chromosome territory relocation by nuclear motor activity in response to serum removal in primary human fibroblasts [PDF]

, 2010
This article has been made available through the Brunel Open Access Publishing Fund.Background: Radial chromosome positioning in interphase nuclei is nonrandom and can alter according to developmental, differentiation, proliferation, or disease status.
Ishita S Mehta, Bridger, JM, Joanna M Bridger, Mehta, IS, Manelle Amira, Harvey, AJ, Amira, M, Amanda J Harvey   +7 more
core   +1 more source

Long Noncoding RNAs in Aortic Dissection: Mechanistic Roles and Therapeutic Potential

AGING MEDICINE, EarlyView.
Aortic dissection (AD) involves vascular inflammation, VSMC dysfunction, and ECM degradation. LncRNAs regulate AD progression via ceRNA networks, with great potential as diagnostic biomarkers and therapeutic targets, while further clinical validation is needed.
Chao Chang, Yongrong Lan, Zhenhua Wu, Jie Geng, Zhigang Guo, Qingliang Chen   +5 more
wiley   +1 more source

Lack of replication for the myosin-18B association with mathematical ability in independent cohorts [PDF]

, 2015
SP is a Royal Society University Research Fellow. This specific study in the ALSPAC cohort was supported by a MRC grant to SP [grant number G0800523/8647].
Newbury, Dianne F, Pettigrew, Kerry A, Wang, Carol, Paracchini, S., Fisher, S E, Consortium, S.L.I., Simpson, N., Fisher, S. E., S. E. Fisher, Ring, Susan, Simpson, N H, K. Northstone, N. H. Simpson, Newbury, D., S. Paracchini, Whitehouse, A. J. O., Fajutrao Valles, S F, Leavett, R, S. Ring, Moll, K, Snowling, M. J., Fajutrao Valles, S. F., M. E. Hayiou‐Thomas, M. J. Snowling, Fajutrao Valles, Samuelle F, Hayiou-Thomas, M.E., K. A. Pettigrew, Hayiou-Thomas, M E, Whitehouse, Andrew J O, Whitehouse, A., Thompson, Paul, Newbury, D.F., Moll, K., K. Moll, Ring, S, Simpson, N. H., C. Pennell, Simpson, N.H., Leavett, R., ?, ?, Whitehouse, A.J.O., Pettigrew, K A, Fajutrao Valles, S., Clark, Ann, Northstone, K., Pennell, C, A. J. O. Whitehouse, Hayiou-Thomas, Marianna E, Paracchini, Silvia, Simpson, Nuala H, Snowling, M.J., Northstone, K, D. F. Newbury, Snowling, M J, Newbury, D F, Thompson, P., Pettigrew, K. A., Wang, C, Newbury, D. F., Pettigrew, K.A., Hayiou-Thomas, M. E., Thompson, Paul A., Pettigrew, K., Wang, C., SLI Consortium, P. Thompson, Moll, Kristina, Fisher, Simon E, Fisher, S.E., S. F. Fajutrao Valles, Fisher, S., Northstone, Kate, Pennell, Craig, Paracchini, S, Valles, S.F.F., Snowling, M., R. Leavett, Pennell, C., Watson, Jocelynne, C. Wang, Fajutrao-Valles, S. F., Whitehouse, A J O, Leavett, Ruth, Snowling, Margaret J, Thompson, P, Ring, S., Hayiou-Thomas, M.   +86 more
core   +2 more sources

Characterization and Selection of Contractile Actuators for Soft Robotics Operating in the Quasistatic Regime

Advanced Intelligent Systems, EarlyView.
We developed methods to characterize soft contractile actuators using force–displacement measurements in the passive state and the total force in the active state and define the operational range of thermal, electrothermal, and pneumatic muscles. A graphical method enables the selection of an actuator based on the required mechanical force–displacement
Qiong Wang, Liuyang Cheng, Jeongmin Kim, Samuel Tsai, Devin Roach, Sameh Tawfick   +5 more
wiley   +1 more source

Diminished climing fiber innervation of Purkinje cells in the cerebellum of myosin Va mutant mice and rats [PDF]

, 2007
Myosin Va is an actin-based molecular motor that is involved in organelle transport and membrane trafficking. Here, we explored the role of myosin Va in the formation of synaptic circuitry by examining climbing fiber (CF) innervation of Purkinje cells ...
Otsuka, Hiroyuki, Murata, Yoshiharu, Takagishi, Yoshiko, Hashimoto, Kouichi, Mizoguchi, Akira, Kayahara, Tetsuro, Kano, Masanobu, Watanabe, Masahiko   +7 more
core   +1 more source

Expanded Phenotype Associated With an Intronic PPP1R12A Variant: A Case Report and Literature Review

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Autosomal dominant PPP1R12A‐related genitourinary and/or brain malformation syndrome is a recently described multisystem disorder caused by loss‐of‐function variants in the protein phosphatase 1 regulatory subunit 12a (PPP1R12A) gene. To date, 22 affected individuals have been reported with variable brain malformations and genitourinary ...
Emily M. Bland, Amber Nakar Weinstein, Eric C. Kao, Xiaonan Zhao, Monika Weisz‐Hubshman   +4 more
wiley   +1 more source

Myosin Assembly, Maintenance and Degradation in Muscle: Role of the Chaperone UNC-45 in Myosin Thick Filament Dynamics

, 2008
Myofibrillogenesis in striated muscle cells requires a precise ordered pathway to assemble different proteins into a linear array of sarcomeres. The sarcomere relies on interdigitated thick and thin filaments to ensure muscle contraction, as well as ...
Kachur, T.M., Pilgrim, D.B.
core   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source