Results 91 to 100 of about 181,791 (317)

Dynamic Self‐Clickable Decellularized Matrix Hydrogels for Regulating Vascularity and Enhancing Muscle Regeneration

Advanced Science, EarlyView.
Dynamic decellularized hydrogels are prepared using bovine decellularized small intestine submucosa (SIS) norbornene (dSIS‐NB). Bovine dSIS contained significant amounts of disulfide‐rich fibrillin‐I, enabling ‘self‐clickable’ thiol‐norbornene gelation and spatiotemporal tuning of hydrogel physicochemical properties.
Van Thuy Duong, Tuba Marjan, Ngoc Ha Luong, Taimoor H. Qazi, Chien‐Chi Lin   +4 more
wiley   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Myosin Assembly, Maintenance and Degradation in Muscle: Role of the Chaperone UNC-45 in Myosin Thick Filament Dynamics

, 2008
Myofibrillogenesis in striated muscle cells requires a precise ordered pathway to assemble different proteins into a linear array of sarcomeres. The sarcomere relies on interdigitated thick and thin filaments to ensure muscle contraction, as well as ...
Kachur, T.M., Pilgrim, D.B.
core   +1 more source

Effects of myosin heavy chain (MHC) plasticity induced by HMGCoA-reductase inhibition on skeletal muscle functions. [PDF]

, 2011
The rate-limiting step of cholesterol biosynthetic pathway is catalyzed by 3-hydroxy-3-methylglutaryl coenzyme reductase (HGMR), whose inhibitors, the statins, widely used in clinical practice to treat hypercholesterolemia, often cause myopathy, and ...
Moreno, Sandra, Swiezewska, Ewa, Linari, Marco, Fanelli, Francesca, V. Trezza, Segatto, Marco, L. Melli, Marco Segatto, L. p. Pucillo, Patrizia Campolongo, Pallottini, Valentina, Laura Trapani, Leopoldo Paolo Pucillo, Viviana Trezza, S. Moreno, F. Fanelli, A. Jozwiak, M. Segatto, V. Pallottini, Campolongo, Patrizia, Melli, Luca, Sandra Moreno, Francesca Fanelli, Marco Linari, Trezza, Viviana, E. Swiezewska, L. Trapani, Trapani, Laura, Valentina Pallottini, Adam Jozwiak, Luca Melli, Ewa Swiezewska, Jóźwiak, Adam, M. Linari, Pucillo, Leopoldo Paolo   +34 more
core   +1 more source

A moving myosin motor protein

, 2013
The muscle myosin is a dimer of two identical motor heads (catalytic cores are blue; lever arms in the prestroke ADP-Pi state are yellow), which are anchored to the thick filament (top) by a coiled coil (gray rod extending to the upper right). In the ADP-
Vale, Ronald D., Milligan, Ronald A.
core   +1 more source

Cancer‐Associated Fibroblast‐Derived Sphingosine‐1‐Phosphate Activates a MALL–SDC4 Axis to Facilitate Perineural Invasion in Pancreatic Cancer

Advanced Science, EarlyView.
CAF‐derived S1P activates the S1PR3‐JNK‐Jun signaling pathway, thereby transcriptionally upregulating MALL expression in cancer cells. MALL increases the cell‐surface abundance of SDC4 by promoting its recycling and restricting its lysosomal degradation, which in turn enhances RhoA‐p‐MLC2‐dependent amoeboid invasion and SDC4‐PTN axis‐mediated cancer ...
Wang Peng, Mengdie Cao, Hai Huang, Shuya Bai, Luyao Liu, Jingwen Liang, Haochen Cui, Qiaodan Zhou, Shiru Chen, Jiamei Jiang, Luoxia Liu, Zhou Luan, Wei Chen, Si Xiong, Ronghua Wang, Bin Cheng, Yuchong Zhao   +16 more
wiley   +1 more source

The Hypertrophic Cardiomyopathy Myosin Mutation R453C Alters ATP Binding and Hydrolysis of Human Cardiac beta-Myosin

, 2014
The human hypertrophic cardiomyopathy mutation R453C results in one of the more severe forms of the myopathy. Arg-453 is found in a conserved surface loop of the upper 50-kDa domain of the myosin motor domain and lies between the nucleotide binding ...
Geeves, M., Leinwand, Leslie A., Combs, A., Geeves, Michael A., Vera, Carlos, Combs, Ariana, Deacon, John C., Bloemink, Marieke J., Langer, Stephen, Deacon, J., Vera, C., Bloemink, M., Langer, S., Leindwand, L.   +13 more
core   +1 more source

Glycogen Synthase Kinase (GSK) 3β phosphorylates and protects nuclear myosin 1c from proteasome-mediated degradation to activate rDNA transcription in early G1 cells [PDF]

, 2014
Nuclear myosin 1c (NM1) mediates RNA polymerase I (pol I) transcription activation and cell cycle progression by facilitating PCAF-mediated H3K9 acetylation, but the molecular mechanism by which NM1 is regulated remains unclear.
Laura Borgonovo-Brandter (573527), Neus Visa (245920), Gothenburg University., Al-Muzzaini, Bader, Anne Von Euler, Von Euler Anne, Sarshad, Aishe A., Visa, Neus,, Laura Borgonovo-Brandter, Martin Corcoran (573526), Borgonovo-Brandter Laura, Martin Corcoran, Piergiorgio Percipalle (393101), Borgonovo-Brandter, Laura, Visa, Neus, Göteborgs universitet., Lamont, Douglas, Sarshad, Aishe A.,, Corcoran, Martin, Percipalle Piergiorgio, Von Euler, Anne, Percipalle, Piergiorgio, Al-Muzzaini Bader, Corcoran Martin, Visa Neus, Douglas Lamont (573529), Lamont Douglas, Aishe A Sarshad, Bader Al-Muzzaini, Anne Von Euler (573528), Sarshad Aishe A., Von Euler, Anne,, Bader Al-Muzzaini (393098), Douglas Lamont, Aishe A. Sarshad (573525), Neus Visa, Piergiorgio Percipalle   +36 more
core   +1 more source

Effect of the Partial Substitution of NaCl with L-Arg on the Gel Properties and Aggregation Behavior of Beef Myosin

Foods
With 0.3 M KCl replacing NaCl, the effect of L-Arg on beef myosin’s gel, structure, and aggregation was investigated. L-Arg could enhance hydrogen and ionic bonds, increasing myosin solubility and reducing turbidity.
Chuanlong Yu, Lingli Chen, Kehui Ouyang, Hui Chen, Suyun Lin, Wenjun Wang   +5 more
doaj   +1 more source

The effect of Arginine, Lysine and Histidine in the myosin secondary structure by circular dichroism and Raman spectroscopy

CyTA - Journal of Food, 2019
Amino acids containing L-Arginine (Arg), L-Lysine (Lys) and L-Histidine (His) are recognized to increase the solubility of myosin at low ionic strength, but there is a difference in the researchers’ views on their effects on the secondary structure of ...
Tong Shi, Li Yuan, Jianlou Mu, Ruichang Gao   +3 more
doaj   +1 more source