Single-molecule studies of unconventional motor protein myosin VI [PDF]
, 2011 Myosin VI is one of the myosin superfamily members that are actin-based molecular motors. It has received special attention due to its distinct features as compared to other myosins, such as its opposite directionality and a much larger step size than ...
Kim, HyeongJun
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The Most Prevalent Freeman-Sheldon Syndrome Mutations in the Embryonic Myosin Motor Share Functional Defects. [PDF]
, 2016 The embryonic myosin isoform is expressed during fetal development and rapidly down-regulated after birth. Freeman-Sheldon syndrome (FSS) is a disease associated with missense mutations in the motor domain of this myosin.
Bloemink, Marieke J. +9 more
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Myosin-Catalyzed ATP Hydrolysis in the Presence of Disease-Causing Mutations: Mavacamten as a Way to Repair Mechanism [PDF]
Hypertrophic cardiomyopathy is one of the most common forms of genetic cardiomyopathy. Mavacamten is a first-in-class myosin modulator that was identified via activity screening on the wild type, and it is FDA-approved for the treatment of obstructive ...
Steven D. Schwartz (1355667) +2 more
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The slow sarco/endoplasmic reticulum Ca2+-ATPase declines independently of slow myosin in soleus muscle of diabetic rats [PDF]
, 2009 The sarcoplasmic reticulum Ca2+-ATPase (SERCA) isoforms are normally expressed in coordination with the corresponding myosin heavy chain (MyHC) isoforms in the fibers of skeletal muscle but this coordination is often disrupted in pathological conditions.
Rácz, Gábor +7 more
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The clinical characteristics of families with hypertrophic cardiomyopathy associated with mutations of cardiac myosin binding protein C [PDF]
, 2010 Introduction: Mutations in cardiac myosin binding protein-C (MYBPC3), the most common genetic cause of hypertrophic cardiomyopathy (HCM), have been reported to cause a comparatively benign and late-onset form of the disease with incomplete penetrance ...
Page, S.P.
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One must reconstitute the functions of interest from purified proteins
Frontiers in PhysiologyI am often asked by students and younger colleagues and now by the editors of this issue to tell the history of the development of the in vitro motility assay and the dual-beam single-molecule laser trap assay for myosin-driven actin filament movement ...
James A. Spudich
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The relay-converter interface influences hydrolysis of ATP by skeletal muscle myosin II [PDF]
, 2015 The interface between relay and converter domain of muscle myosin is critical for optimal myosin performance. Using Drosophila melanogaster indirect flight muscle S1 we performed a kinetic analysis of the effect of mutations in the converter and relay ...
Geeves, M. +3 more
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Pathophysiology of human hearing loss associated with variants in myosins
Frontiers in PhysiologyDeleterious variants of more than one hundred genes are associated with hearing loss including MYO3A, MYO6, MYO7A and MYO15A and two conventional myosins MYH9 and MYH14. Variants of MYO7A also manifest as Usher syndrome associated with dysfunction of the
Takushi Miyoshi +4 more
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Effect of Catechins on the Physicochemical, Structural and Gel Properties of Myosin in Tilapia
Shipin gongye ke-jiThis study investigated the influence of different mass concentrations of catechin (0~1.00 mg/mL) on the physicochemical characteristics, structures, and gel properties of myosin, through analyses of the turbidity, particle size, Zeta potential, surface ...
Yuyu HANG, Yang ZHANG, Du TAN, Yaqin HU
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The order of things: phosphate release or the power stroke, which does actomyosin do first?
Frontiers in PhysiologyMyosins are a highly conserved super family of motor proteins that are responsible for driving a host of intracellular processes in eukaryotes, from muscle contraction to vesicular transport.
Edward P. Debold +2 more
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