Results 31 to 40 of about 94,421 (295)

The Formin Inhibitor, SMIFH2, Inhibits Members of the Myosin Superfamily [PDF]

Biophysical Journal, 2020
AbstractThe small molecular inhibitor of formin FH2 domains, SMIFH2, is widely used in cell biological studies. It was selected in a chemical screen as a compound inhibiting formin-driven actin polymerizationin vitro, but not polymerization of pure actin, and found to be active against several types of formins from different species (Rizvi et al., 2009)
Yukako Nishimura, Shidong Shi, Fang Zhang, Rong Liu, Yasuharu Takagi, Alexander D. Bershadsky, Virgile Viasnoff, James R. Sellers   +7 more
openaire   +4 more sources

Left ventricular outflow tract obstruction in hypertrophic cardiomyopathy and the impact of mavacamten

Therapeutic Advances in Chronic Disease, 2022
Hypertrophic cardiomyopathy (HCM) is a common genetic disorder characterised by unexplained left ventricular hypertrophy. Left ventricular outflow tract obstruction is an integral component of the disease, often resulting in significant symptoms, but ...
Susan Mathai, Lynne Williams
doaj   +1 more source

Rapid chromosome territory relocation by nuclear motor activity in response to serum removal in primary human fibroblasts [PDF]

, 2010
This article has been made available through the Brunel Open Access Publishing Fund.Background: Radial chromosome positioning in interphase nuclei is nonrandom and can alter according to developmental, differentiation, proliferation, or disease status.
Amira, M, Bridger, JM, Harvey, AJ, Mehta, IS   +3 more
core   +2 more sources

A pharmacological cocktail for arresting actin dynamics in living cells. [PDF]

, 2011
The actin cytoskeleton is regulated by factors that influence polymer assembly, disassembly, and network rearrangement. Drugs that inhibit these events have been used to test the role of actin dynamics in a wide range of cellular processes.
Peng, Grace E, Weiner, Orion D, Wilson, Sarah R   +2 more
core   +2 more sources

A permeabilized cell model for studying cell division: a comparison of anaphase chromosome movement and cleavage furrow constriction in lysed PtK1 cells. [PDF]

, 1981
After lysis in a Brij 58-polyethylene glycol medium, PtK1 cells are permeable to small molecules, such as erythrosin B, and to proteins, such as rhodamine-labeled FAB, myosin subfragment-1, and tubulin.
CANDE, W. Zacheus, McDonald, K, Meeusen, R   +2 more
core   +2 more sources

The actin-myosin regulatory MRCK kinases: regulation, biological functions and associations with human cancer [PDF]

, 2014
The contractile actin-myosin cytoskeleton provides much of the force required for numerous cellular activities such as motility, adhesion, cytokinesis and changes in morphology.
AP Somlyo, B Rafn, C Gaggioli, C Gally, CL Moncrieff, CS Loo, D Pyeon, DA Heerding, DM Pirone, DR Rhodes, ER Gomes, ET Kimchi, F Corpet, G Brunhofer, G Groeger, H Yamaguchi, HI Lowe, I Tan, I Tan, I Tan, I Tan, I Tan, J Schlingemann, J Schwarz, JM Elkins, JM Herbert, K Ando, K Lefort, KE Fisher, L Huo, L Luo, LJ Veer van’t, LR Pearce, LT Lam, M Jacobs, M Uehata, M Vicente-Manzanares, MA Fabian, MA Ginos, Mathieu Unbekandt, MF Olson, MF Olson, Michael F. Olson, N Nakamura, N Rath, P Basu, P Madaule, PL Podolin, R Cmejla, RW Scott, S Balasenthil, S Wang, S Wilkinson, S Yamamoto, SH Choi, SM Kim, T Heikkila, T Leung, T Sumi, X Liu, Y Hao, Y Ng, Y Zhao   +62 more
core   +1 more source

Clinical Trials in Hypertrophic Cardiomyopathy Therapy: A Comprehensive Analysis of Trials Registered in Global Clinical Databases

Drug Design, Development and Therapy, 2023
Huan Zhang,1,2,* Cheng Yu,1,* Yuanling Cheng,1 Zhi Chen,2 Min Chen,2 Wangan He,1 Zhigang Jin,1 Shaoqian Cai,1 Lijuan Yu2 1Department of Cardiology, China Resources & Wisco General Hospital, Wuhan University of Science and Technology, Wuhan ...
Zhang H, Yu C, Cheng Y, Chen Z, Chen M, He W, Jin Z, Cai S, Yu L   +8 more
doaj  

MYH3‐associated distal arthrogryposis zebrafish model is normalized with para‐aminoblebbistatin

EMBO Molecular Medicine, 2020
Distal arthrogryposis (DA) is group of syndromes characterized by congenital joint contractures. Treatment development is hindered by the lack of vertebrate models.
Julia Whittle, Lilian Antunes, Mya Harris, Zachary Upshaw, Diane S Sepich, Aaron N Johnson, Mayssa Mokalled, Lilianna Solnica‐Krezel, Matthew B Dobbs, Christina A Gurnett   +9 more
doaj   +1 more source

Spheroid Fabrication Using Concave Microwells Enhances the Differentiation Efficacy and Function of Insulin-Producing Cells via Cytoskeletal Changes

Cells, 2020
Pancreatic islet transplantation is the fundamental treatment for insulin-dependent diabetes; however, donor shortage is a major hurdle in its use as a standard treatment. Accordingly, differentiated insulin-producing cells (DIPCs) are being developed as
Yu Na Lee, Hye Jin Yi, Hanse Goh, Ji Yoon Park, Sarah Ferber, In Kyong Shim, Song Cheol Kim   +6 more
doaj   +1 more source

Rho-Associated Kinases and Non-muscle Myosin IIs Inhibit the Differentiation of Human iPSCs to Pancreatic Endoderm

Stem Cell Reports, 2017
Summary: There has been increasing success with the generation of pancreatic cells from human induced pluripotent stem cells (hiPSCs); however, the molecular mechanisms of the differentiation remain elusive.
Taro Toyoda, Azuma Kimura, Hiromi Tanaka, Tomonaga Ameku, Atsushi Mima, Yurie Hirose, Masahiro Nakamura, Akira Watanabe, Kenji Osafune   +8 more
doaj   +1 more source