Results 151 to 160 of about 12,413 (263)

Semaglutide normalizes increased cardiomyocyte calcium transients in a rat model of high fat diet‐induced obesity

ESC Heart Failure, Volume 12, Issue 2, Page 1386-1397, April 2025.
Sequeira et al. reveal how the glucagon‐like peptide‐1 receptor agonist (GLP‐1‐RA) semaglutide restores cardiomyocyte function in rats subjected to a high‐fat/high‐fructose diet (HFD). Employing fluorescence‐ and patch‐clamp technology in isolated cardiac myocytes, they demonstrate that semaglutide reverses HFD‐induced activation of L‐type calcium ...
Vasco Sequeira, Julia Theisen, Katharina J. Ermer, Marie Oertel, Anton Xu, David Weissman, Katharina Ecker, Jan Dudek, Martin Fassnacht, Alexander Nickel, Michael Kohlhaas, Christoph Maack, Ulrich Dischinger   +12 more
wiley   +1 more source

Antimalarial cytoskeletal targeting with broad apicomplexan activity. [PDF]

Proc Natl Acad Sci U S A
Trivedi DV, Karabina A, Jiang T, Chen D, Mittal N, Huijs T, van der Laak R, Jeon JH, Yeo T, Moussaoui D, Robblee JP, Akey M, Freese M, Fuller L, Bergnes G, Racca A, Wander H, Jung S, Ouchida S, Ruijgrok PV, Song D, Spudich A, Ruppel KM, Nag S, Mueller-Dieckmann C, Burrows JN, Laleu B, Guido RVC, Campos Aguiar AC, Pereira DB, Wittlin S, Mukherjee P, Chakraborty A, Aggrey SE, Robert-Paganin J, Trybus KM, Sibley LD, Houdusse A, Fidock DA, Dechering KJ, Winzeler EA, Spudich JA.   +41 more
europepmc   +1 more source

Uncovering cardiac molecular remodelling in racing Thoroughbreds with paroxysmal atrial fibrillation

Equine Veterinary Journal, EarlyView.
Abstract Background Atrial fibrillation (AF) is the most common arrhythmia in both humans and horses, with a comparable prevalence of ~2%. In horses, AF is a major cause of poor athletic performance and linked to sudden cardiac death, yet its underlying molecular mechanisms remain poorly understood.
Charlotte E. Edling, Magdalena Arevalo‐Turrubiarte, Carla Moller‐Levet, Bronte Forbes, Victoria Kemp, Joe Weir, Gary Tse, Celia Marr, Rebecca Lewis, Kamalan Jeevaratnam   +9 more
wiley   +1 more source

Structural and Functional Stability of Natural Actomyosin From Freshwater Snail (Bellamya bengalensis): Unraveling Thermal and pH Effects

Food Chemistry International, EarlyView.
Natural actomyosin from B. bengalensis exhibited maximum solubility (∼69.9%) at 40°C and stability near neutral pH, with minimum solubility at pH 4. Surface hydrophobicity and emulsifying activity peaked at 50°C, whereas Ca2+‐ATPase and foaming peaked at 40°C. DSC and SDS–PAGE confirmed denaturation above 40°C.
Krishan Kumar Yadav, Naresh Kumar Mehta, Sanjeev Sharma, M. Bhargavi Priyadarshini, Himanshu Priyadarshi, Prasenjit Pal, Harjeet Nath, Sneha Chaudhury   +7 more
wiley   +1 more source

The structure of the native cardiac crossbridge in the rigor state. [PDF]

Sci Adv
Risi CM, Nguyen T, Belknap B, White HD, Pinto JR, Chase PB, Galkin VE.   +6 more
europepmc   +1 more source

Alternative protein sources: Extraction, modification and strategies for developing sustainable high‐quality food products

Food Biomacromolecules, EarlyView.
Novel Protein Sources: Strategies and Challenges for Product Formulation Abstract Search for alternative protein sources has intensified in the recent years, owing to the increasing population, demand for sustainable food systems and consumer's shift towards healthier diet choices.
Prem Sankaran, Baskaran Nagarethinam, Sunil Chikkaballapur Krishnappa, Chandrasekar Veerapandian, Ashish Rawson   +4 more
wiley   +1 more source

Drosophila myosin function and muscle structure are modulated by isoform-specific amino acid residues of the relay domain. [PDF]

Biochem Biophys Res Commun
Kronert WA, Melkani GC, Melkani A, Bernstein SI.   +3 more
europepmc   +1 more source

Elucidating chiral myosin-induced actin dynamics: From single-filament behavior to collective structures. [PDF]

Proc Natl Acad Sci U S A
Haraguchi T, Yoshimura K, Inoue Y, Imi T, Hasegawa K, Nagai T, Furusawa H, Mori T, Matsuno K, Ito K.   +9 more
europepmc   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Long‐Read Pan‐Cancer Transcriptomics Unravel Distinct Alteration Trends Between Gene and Isoform Expression in Tumorigenesis

iMetaMed, EarlyView.
Long‐read profiling of 144 tumor‐normal pairs identifies isoform‐level cancer dysregulation independent of gene changes. Our scoring system prioritizes isoform‐driven prognostic genes across cancers. ABSTRACT Tumorigenesis involves transcriptomic alterations at both gene and isoform levels.
Yuying Ding, Bo Wu, Dan Zhou, Qiang Li, Dingru Li, Mengyun Cai, Zhiyan Chen, Caimei Zhong, ChuanLe Xiao, Yuhua Deng   +9 more
wiley   +1 more source