Results 161 to 170 of about 20,285 (238)

Association between Perceived Dysphagia Symptoms and Swallowing Physiology in Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Swallowing disorders are prevalent in Parkinson's disease (PD). Swallowing assessment often relies on patient‐reported outcome measures (PROMs). Although PROMs and physiologic swallowing measures correlate with disease severity, the relationship between PROMs and physiologic swallowing impairments is unclear.
Rabab Rangwala, Mariana Mendes Bahia, Jing Song, Danny Bega, Bonnie Martin‐Harris   +4 more
wiley   +1 more source

Myosin-1C differentially displaces tropomyosin isoforms altering their inhibition of motility. [PDF]

J Biol Chem
Pollard LW, Boczkowska M, Dominguez R, Ostap EM.   +3 more
europepmc   +1 more source

Myosin Myopathies [PDF]

Biophysical Journal, 2015
openaire   +1 more source

The Role of Repeat Skeletal Muscle Biopsy: Indications, Yield and Outcomes

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Muscle biopsy performed to investigate weakness and/or pain may be nondiagnostic and prompt repeat biopsy. We determined the indications and yield of rebiopsy. Methods Patients who underwent > 1 muscle biopsy (South Australia, 2000–2023) were identified.
Thomas Khoo, Sarah Saxon, Barbara Koszyca, Bernice Gutschmidt, Vidya Limaye   +4 more
wiley   +1 more source

A combined experimental and computational analysis of mantATP turnover in skinned muscle fibers. [PDF]

Proc Natl Acad Sci U S A
Montesel M, De Napoli C, Schmidt L, Germinario E, Guzman UH, Olsen JV, Marcucci L, Nogara L.   +7 more
europepmc   +1 more source

A Phase 1, Double‐Blind, Placebo‐Controlled Trial of Sevasemten (EDG‐5506), a Selective Modulator of Fast Skeletal Muscle Contraction, in Healthy Volunteers and Adults With Becker Muscular Dystrophy

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Sevasemten (EDG‐5506) is an orally administered, investigational small molecule that selectively modulates fast muscle fiber contraction by inhibiting fast myosin ATPase. This study assessed the safety, tolerability, and pharmacokinetics (PK)/pharmacodynamics (PD) of sevasemten in healthy adult volunteers (HVs) and adults ...
Joanne Donovan, Jeffrey A. Silverman, Ben Barthel, Michael DuVall, Molly Madden, James MacDougall, Nicole Rempel Kilburn, Abby Bronson, Marc Evanchik, Gilad Gordon, Kevin Koch, Alan J Russell   +11 more
wiley   +1 more source

Transition to Piscivory Seen Through Brain Transcriptomics in a Juvenile Percid Fish: Complex Interplay of Differential Gene Transcription, Alternative Splicing, and ncRNA Activity. [PDF]

J Exp Zool A Ecol Integr Physiol
Symonová R, Jůza T, Tesfaye M, Brabec M, Bartoň D, Blabolil P, Draštík V, Kočvara L, Muška M, Prchalová M, Říha M, Šmejkal M, Souza AT, Sajdlová Z, Tušer M, Vašek M, Skubic C, Brabec J, Kubečka J.   +18 more
europepmc   +1 more source

Mitochondrial transfer as a novel therapeutic approach in ischemic stroke treatment: Current challenges and future perspectives

Neuroprotection, EarlyView.
Cerebral ischemia is a serious neurological disease that mainly leads to pathological changes such as mitochondrial dysfunction, oxidative stress and iron death. Mitochondria play a key role in the regulation of cellular energy metabolism and oxidative stress, and their damage can lead to mitochondrial damage, reduced adenosine triphosphate production,
Shuchen Meng, Min Bai, Changsheng Ma, Bo Han, Mengyuan Duan, Liying Zhang, Jinfen Guo, Changku Shi, Ke Li, Maotao He   +9 more
wiley   +1 more source