Results 201 to 210 of about 40,761 (237)

Semaglutide normalizes increased cardiomyocyte calcium transients in a rat model of high fat diet‐induced obesity

ESC Heart Failure, Volume 12, Issue 2, Page 1386-1397, April 2025.
Sequeira et al. reveal how the glucagon‐like peptide‐1 receptor agonist (GLP‐1‐RA) semaglutide restores cardiomyocyte function in rats subjected to a high‐fat/high‐fructose diet (HFD). Employing fluorescence‐ and patch‐clamp technology in isolated cardiac myocytes, they demonstrate that semaglutide reverses HFD‐induced activation of L‐type calcium ...
Vasco Sequeira, Julia Theisen, Katharina J. Ermer, Marie Oertel, Anton Xu, David Weissman, Katharina Ecker, Jan Dudek, Martin Fassnacht, Alexander Nickel, Michael Kohlhaas, Christoph Maack, Ulrich Dischinger   +12 more
wiley   +1 more source

Increasing Cardiac Myosin Super-Relaxation With Decreasing Metabolic Demand. [PDF]

J Am Heart Assoc
Ochala J, Galán-Arriola C, Veiberg V, Ibanez B.   +3 more
europepmc   +1 more source

Comparative Analysis of the Fecal Proteome in Two Canine Breeds: Dalmatians and Weimaraners. [PDF]

Int J Mol Sci
Cerquetella M, Pinnella F, Morazzini R, Rossi G, Marchegiani A, Gavazza A, Mangiaterra S, Di Cerbo A, Sorio D, Brandi J, Cecconi D, Vincenzetti S.   +11 more
europepmc   +1 more source

Inflammation and genetics in myo‐pericardial diseases: Insights from the Italian Study Group on Cardiomyopathies and Pericardial Diseases

ESC Heart Failure, EarlyView.
Proposed management of myo‐pericardial diseases. A systematic interdisciplinary approach to myo‐pericardial disease is essential to reach a correct diagnosis, starting from multiparametric characterization including EKG, echocardiography with GLS, laboratory exams and CMR or, in case of electric or haemodynamic instability, EMB.
Marco Merlo, Giulia Bassetto, Antonio Cannatà, Alberto Aimo, Camillo Autore, Barbara Bauce, Elena Biagini, Francesco Cappelli, Silvia Castelletti, Flavio D'Ascenzi, Cesare de Gregorio, Giuseppe Limongelli, Francesca Marzo, Beatrice Musumeci, Giacomo Tini, Roberto Pedrinelli, Pasquale Perrone Filardi, Gianfranco Sinagra, Massimo Imazio   +18 more
wiley   +1 more source

Early diagnostic value of novel biomarkers for breast cancer therapy‐related cardiac dysfunction

ESC Heart Failure, EarlyView.
Our meta‐analysis revealed significant post‐treatment increases in GDF‐15, CRP, MPO, and PLGF levels (Gal‐3 unchanged) among breast cancer patients. Only elevated MPO levels were significantly associated with an increased risk of cancer therapy‐related cardiac dysfunction (CTRCD).
Zhengwei Wang, Yujuan Wu, Jingyi He, Diansa Gao, Zhong Zuo   +4 more
wiley   +1 more source

Stuck in Traffic-Myosin Motors Ease Gridlock in the Loop. [PDF]

Function (Oxf)
Curry JN, McCormick JA.
europepmc   +1 more source

Broad therapeutic benefit of myosin inhibition in hypertrophic cardiomyopathy [PDF]

Laura Sen-Martín, Ángel Fernández‐Trasancos, Miguel A. López‐Unzu, Divya Pathak, Alessia Ferrarini, V. Labrador, David Sánchez-Ortiz, María Rosaria Pricolo, Natália Vicente, Diana Velázquez-Carreras, Lucía Sánchez-García, José Ángel Nicolás-Ávila, María Sánchez-Díaz, Saskia Schlossarek, Lorena Cussó, Manuel Desco, María Villalba‐Orero, Gabriela Guzmán, Enrique Calvo, Roberto Barriales‐Villa, Jesús Vázquez, Fátima Sánchez‐Cabo, Andrés Hidalgo, Lucie Carrier, James A. Spudich, Kathleen M. Ruppel, Jorge Alegre-Cebollada   +26 more
openalex   +1 more source

Worsening versus advanced heart failure: Management and challenges

ESC Heart Failure, EarlyView.
Clinical feature, circulating biomarkers and therapeutic management of patients with WHF versus AdvHF. Abbreviations: AdvHF, advanced heart failure; HF, heart failure; HTx, heart transplant; GDMT, guideline‐directed medical therapy; MCS, mechanical circulatory support; NYHA, New York Heart Association; WHF, worsening heart failure.
Alberto Palazzuoli, Marco Giuseppe Del Buono, Giulia La Vecchia, Stephen J. Greene, Andrew P. Ambrosy, Ovidiu Chioncel, Finn Gustafsson, Selim R. Krim, Carl J. Lavie, Marianna Adamo, Tuvia Ben Gal, Oliviana Geavlete, Laura Antohi, Giuseppe Rosano, Sean Collins, Filippo Crea   +15 more
wiley   +1 more source

Super-relaxed myosins contribute to respiratory muscle hibernation in mechanically ventilated patients. [PDF]

Sci Transl Med
van den Berg M, Shi Z, Claassen WJ, Hooijman P, Lewis CTA, Andersen JL, van der Pijl RJ, Bogaards SJP, Conijn S, Peters EL, Begthel LPL, Uijterwijk B, Lindqvist J, Langlais PR, Girbes ARJ, Stapel S, Granzier H, Campbell KS, Ma W, Irving T, Hwee DT, Hartman JJ, Malik FI, Paul M, Beishuizen A, Ochala J, Heunks L, Ottenheijm CAC.   +27 more
europepmc   +1 more source

Cardioimmunologic response patterns after an acute heart failure event: Design and first results of AHF‐ImmunoCS

ESC Heart Failure, EarlyView.
Abstract Aims We have previously shown that patients who develop heart‐reactive antibodies (HRAs) de novo after a heart failure (HF) hospitalization are at increased risk of adverse outcomes, lending weight to the hypothesis that B cells may play a pivotal role in HF progression.
Niklas Beyersdorf, Boshra Afshar, Dora Pelin, Maximilian Bauser, Elisa Kaiser, Janna Lamers, Jannika Pätkau, Mairin Heil, Dennis Göpfert, Hanna Hepp, Wafaa Al Hassan, Thomas Kerkau, Fabian Kerwagen, Roland Jahns, Valerie Boivin‐Jahns, Stefan Frantz, Gustavo Ramos, Ulrich Hofmann, Stefan Störk, Caroline Morbach   +19 more
wiley   +1 more source