Results 151 to 160 of about 33,582 (263)

Investigation into Developmental Stages of Chicken and Quail Blood to Determine Alternative Splicing Isoforms of Myostatin [PDF]

, 2013
Myostatin is key to understanding avian muscle development, as it is known to negatively regulate skeletal muscle growth. The primary objective of this study was to reveal myostatin isoforms of broiler and layer chickens and the heavyweight, random-bred,
Wheeler, Jessica
core   +1 more source

Distinct Proteomic Signatures Driving Progression of Sarcopenia: A Longitudinal Multicohort Study

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Background Sarcopenia is an age‐related condition characterized by progressive muscle mass, strength and physical performance declines, contributing to frailty and adverse health outcomes. Despite increasing interest in molecular biomarkers, longitudinal data with external validation are limited.
Sung Hye Kong, Ok Hee Jeon, Ji Yeon Kim, Miji Kim, Jinhee Kim, Seung Shin Park, Hak Chul Chang, Chang Won Won, Dohyun Han   +8 more
wiley   +1 more source

Effects of Phenolic‐Rich Extra Virgin Olive Oil and Prebiotics on Sarcopenia in Older Adults: FOOP‐Sarc Project

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Background Management of sarcopenia by nutritional and lifestyle interventions is a challenge. The aim is to assess the effectiveness of a phenolic‐rich extra virgin olive oil (EVOO), alone or combined with a prebiotic (PREB) (fructooligosaccharides and inulin), to improve skeletal muscle mass and function in home‐dwelling older adults (60–80 ...
Maria Besora‐Moreno, Claudia Jiménez‐ten Hoevel, Judit Queral, Glòria Bernal, Laura Pérez‐Merino, José Puzo, Laura Conangla‐Ferrin, Leann Constance Sleebos, Wout van Helden, Elisabet Llauradó, Rosa M. Valls, Rosa Solà, Anna Pedret   +12 more
wiley   +1 more source

Metabolic Functions of Myostatin and GDF11 [PDF]

Immunology‚ Endocrine & Metabolic Agents in Medicinal Chemistry, 2010
Myostatin is a member of the transforming growth factor β superfamily of secreted growth factors that negatively regulates skeletal muscle size. Mice null for the myostatin gene have a dramatically increased mass of individual muscles, reduced adiposity, increased insulin sensitivity, and resistance to obesity.
openaire   +2 more sources

Muscle Weakness and the Irisin–BDNF and Oxidative Stress Axis in the 60‐Day Pseudorandomised Controlled AGBRESA Bed Rest Study

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Background Muscle atrophy and weakness are among the most detrimental consequences of disuse, microgravity, hospitalisation and ageing. Oxidative modifications of myofibrillar proteins generated by oxidative stress may contribute to the reduced force‐ and power‐generating capacity of skeletal muscles. As part of the 60‐day AGBRESA bed rest (BR)
Alessandra Bosutti, Bergita Ganse, Edwin Mulder, Markus Gruber, Maria Venegas‐Carro, Jochen Zange, Jörn Rittweger, Moritz Eggelbusch, Rob C. I. Wüst, Paul Hendrickse, Hans Degens   +10 more
wiley   +1 more source

Future trends in Animal Breeding due to new genetic tecnologies

, 2011
The Darwin theory of evolution by natural selection is based on three principles: (a) variation; (b) inheritance; and (c) natural selection. Here, I take these principles as an excuse to review some topics related to the future research prospects in ...
Toro Ibañez, Miguel Angel
core   +1 more source

KARIs, Ghrelin Receptor Agonists With Excellent Brain Permeability, Increase Food Intake and Attenuate the Muscle Loss in Mice

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Background Ghrelin regulates appetite, gastrointestinal motility and growth hormone (GH) secretion through activation of the growth hormone secretagogue receptor (GHSR‐1a) in hypothalamic neurons, with downstream effects on adipose tissue and skeletal muscle.
Hee Ji Yoon, Wan Hui Han, Sang Bo Kim, Won Gyeong Lee, Seo Young Choi, Byung Jo Choi, Minyeong Pang, Min‐Koo Choi, Jihoon Lee, Im‐Sook Song, Min Hee Park, Hee Kyung Jin, Jae‐sung Bae   +12 more
wiley   +1 more source

Myofibre Density Reveals a Critical Threshold Around Age 6 in Steroid‐Naïve Duchenne Muscular Dystrophy: A Retrospective Observational Study

Neuropathology and Applied Neurobiology, Volume 52, Issue 2, April 2026.
We analysed archival muscle biopsies of steroid‐naïve patients with Duchenne muscular dystrophy (DMD), proposing a novel, simple metric: myofibre density (MFD). MFD sharply declines until age 6, identifying a critical threshold around this age. MFD provides a sensitive, reproducible biomarker for early disease progression, highlighting a potential ...
Tetsuhiro Yamakado, Yuka Ishikawa, Koki Ise, Lei Wang, Yoshitaka Oda, Masumi Tsuda, Taichi Kimura, Masayoshi Nagao, Manabu Ito, Shinya Tanaka, Zen‐ichi Tanei   +10 more
wiley   +1 more source

Understanding Impact of Anti‐Obesity Medications on Skeletal Muscle Mass Change Is Confounded by Measurement Methods

Obesity Reviews, Volume 27, Issue 4, April 2026.
ABSTRACT Anti‐obesity medications promote greater degrees of weight loss than lifestyle interventions alone. There is an important need to understand whether loss of skeletal muscle during pharmacologically induced weight loss is clinically significant due to its essential role in health and disease.
Arden McMath, Dympna Gallagher
wiley   +1 more source

Myostatin-driven muscle hypertrophy: a double-edged sword in muscle physiology

Journal of Rare Diseases
Myostatin (MSTN), a pivotal regulator of skeletal muscle homeostasis, belongs to the TGF-β family and functions as a potent inhibitor of muscle hypertrophy.
Ghisaram Dewasi, Parikshit Nagda, Gurusha Bahl, Vivek Jain, Sanjay Kumar Gupta   +4 more
doaj   +1 more source