Results 41 to 50 of about 33,582 (263)
Journal of Cellular and Molecular Medicine, 2021 Muscle atrophy is a common complication in chronic kidney disease (CKD). Inflammation and myostatin play important roles in CKD muscle atrophy. Formononetin (FMN), which is a major bioactive isoflavone compound in Astragalus membranaceus, exerts anti ...
Ling-yu Liu +10 more
semanticscholar +1 more source
The use of genes for performance enhancement: doping or therapy? [PDF]
, 2011 Recent biotechnological advances have permitted the manipulation of genetic sequences to treat several diseases in a process called gene therapy. However, the advance of gene therapy has opened the door to the possibility of using genetic manipulation ...
Collares, T. F. +4 more
core +5 more sources
MOTS-c reduces myostatin and muscle atrophy signaling.
American Journal of Physiology. Endocrinology and Metabolism, 2021 Obesity and type 2 diabetes are metabolic diseases, often associated with sarcopenia and muscle dysfunction. MOTS-c, a mitochondrial-derived peptide, acts as a systemic hormone and has been implicated in metabolic homeostasis.
H. Kumagai +11 more
semanticscholar +1 more source
Low Myostatin Serum Levels Are Associated with Poor Outcome in Critically Ill Patients
Diagnostics, 2020 Background: Growth differentiation factor 8, GDF-8 (Myostatin), is a protein released by myocytes inhibiting muscle growth and differentiation. Serum concentrations of Myostatin can predict poor survival in different chronic diseases, but its role in ...
Theresa H. Wirtz +12 more
doaj +1 more source
Regulation of tissue crosstalk by skeletal muscle-derived myonectin and other myokines. [PDF]
, 2012 The integrated control of animal physiology requires intimate tissue crosstalk, a vital task mediated by circulating humoral factors. As one type of these factors, adipose tissue-derived adipokines have recently garnered attention as important regulators
Seldin, Marcus M, Wong, G William
core +1 more source
Cytokines and chemokines as regulators of skeletal muscle inflammation: presenting the case of Duchenne muscular dystrophy [PDF]
, 2013 Duchenne muscular dystrophy is a severe inherited muscle disease that affects 1 in 3500 boys worldwide. Infiltration of skeletal muscle by inflammatory cells is an important facet of disease pathophysiology and is strongly associated with disease ...
De Bleecker, Jan, De Paepe, Boel
core +3 more sources
Serum Myostatin among Excessive Drinkers
International Journal of Molecular Sciences, 2023 Myostatin acts as a negative regulator of muscle growth. Its effect on fat mass is subject to debate. Among alcoholics, there is a high prevalence of muscle atrophy, and increased fat deposition has been also described in these patients. Myostatin could be involved in these alterations, but its relationships with body composition have been scarcely ...
Candelaria Martín-González +8 more
openaire +2 more sources
FHL1 activates myostatin signalling in skeletal muscle and promotes atrophy
FEBS Open Bio, 2015 Myostatin is a TGFβ family ligand that reduces muscle mass. In cancer cells, TGFβ signalling is increased by the protein FHL1. Consequently, FHL1 may promote signalling by myostatin. We therefore tested the ability of FHL1 to regulate myostatin function.
Jen Y. Lee +3 more
doaj +1 more source
Frontiers in Pharmacology, 2020 Myostatin is a crucial cytokine that is widely present in skeletal muscle and that negatively regulates the growth and development of muscle cells. Recent research has shown that myostatin might play an essential role in bone metabolism.
Xin Zhi +10 more
doaj +1 more source
Sarcopenia from mechanism to diagnosis and treatment in liver disease [PDF]
, 2016 Sarcopenia or loss of skeletal muscle mass is the major component of malnutrition and is a frequent complication in cirrhosis that adversely affects clinical outcomes.
Dasarathy, Srinivasan, MERLI, Manuela
core +1 more source