Results 61 to 70 of about 26,633 (217)
3152 The role of myostatin in diabetic bone disease
Journal of Clinical and Translational Science, 2019 OBJECTIVES/SPECIFIC AIMS: Our primary objective is to determine the mechanism of action of myostatin on osteoblasts by measuring markers of osteoblast differentiation.
Evangelia Kalaitzoglou +2 more
doaj +1 more source
Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues
ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang +7 more
wiley +1 more source
Plasma and muscle myostatin in relation to type 2 diabetes.
PLoS ONE, 2012 ObjectiveMyostatin is a secreted growth factor expressed in skeletal muscle tissue, which negatively regulates skeletal muscle mass. Recent animal studies suggest a role for myostatin in insulin resistance.
Claus Brandt +5 more
doaj +1 more source
Inhibition of myostatin signaling through Notch activation following acute resistance exercise. [PDF]
PLoS ONE, 2013 Myostatin is a TGFβ family member and negative regulator of muscle size. Due to the complexity of the molecular pathway between myostatin mRNA/protein and changes in transcription, it has been difficult to understand whether myostatin plays a role in ...
Matthew G MacKenzie +4 more
doaj +1 more source
Metabolites, 2023 Myostatin (gene symbol: Mstn) is an autocrine and paracrine inhibitor of muscle growth. Pregnant mice with genetically reduced levels of myostatin give birth to offspring with greater adult muscle mass and bone biomechanical strength.
Ruth Opoku +3 more
doaj +1 more source
A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood. [PDF]
, 2016 Heterochronic parabiosis rejuvenates the performance of old tissue stem cells at some expense to the young, but whether this is through shared circulation or shared organs is unclear.
Causey, Keith +6 more
core +1 more source
Nutrition in Clinical Practice, EarlyView.Abstract Background Although previous experimental studies showed that metabolic acidosis promoted muscle catabolism and impaired protein synthesis, few epidemiological studies reported an independent association between serum bicarbonate levels and muscle atrophy in patients with chronic kidney disease (CKD).
Nobuhisa Morimoto +13 more
wiley +1 more source
Vitamin D, a modulator of musculoskeletal health in chronic kidney disease [PDF]
, 2017 The spectrum of activity of vitamin D goes beyond calcium and bone homeostasis, and growing evidence suggests that vitamin D contributes to maintain musculoskeletal health in healthy subjects as well as in patients with chronic kidney disease (CKD ...
Jordi Bover +6 more
core +2 more sources
British Journal of Pharmacology, EarlyView.Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska +2 more
wiley +1 more source
Frontiers in Physiology, 2021 Skeletal muscle, the most abundant tissue in the body, plays vital roles in locomotion and metabolism. Understanding the cellular processes that govern regulation of muscle mass and function represents an essential step in the development of therapeutic ...
Caroline Barbé +4 more
doaj +1 more source