Fibro-Adipogenic Progenitors Regulate Orofacial Neuromuscular Junction Regeneration via Myostatin. [PDF]
J Cachexia Sarcopenia MuscleABSTRACT Background Orofacial and limb muscles differ in embryonic origin and regenerative capacity. Neuromuscular junction (NMJ) regeneration is critical for muscle restoration both histologically and functionally. The relative potential of orofacial and limb muscles to form postsynaptic apparatuses remains elusive.
Li R +7 more
europepmc +2 more sources
Targeting myostatin/activin A protects against skeletal muscle and bone loss during spaceflight
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Among the major health challenges for astronauts during prolonged space travel are loss of muscle mass and loss of bone mass. Here, we investigated the effects of targeting the signaling pathway mediated by the secreted signaling molecules ...
Se-Jin Lee +14 more
semanticscholar +1 more source
JCSM Clinical Reports, 2021 Myostatin (MSTN) is a key negative regulator of muscle mass in humans and animals, having direct and indirect influences on molecular regulators of atrophy and hypertrophy, thus potentially impacting fitness and physical function.
A. Ryan, Guoyan Li
semanticscholar +1 more source
The Inhibitory Core of the Myostatin Prodomain: Its Interaction with Both Type I and II Membrane Receptors, and Potential to Treat Muscle Atrophy. [PDF]
PLoS ONE, 2015 Myostatin, a muscle-specific transforming growth factor-β (TGF-β), negatively regulates skeletal muscle mass. The N-terminal prodomain of myostatin noncovalently binds to and suppresses the C-terminal mature domain (ligand) as an inactive circulating ...
Yutaka Ohsawa +11 more
doaj +1 more source
The mechanical stimulation of myotubes counteracts the effects of tumor-derived factors through the modulation of the activin/follistatin ratio [PDF]
, 2019 Activin negatively affects muscle fibers and progenitor cells in aging (sarcopenia) and in chronic diseases characterized by severe muscle wasting (cachexia). High circulating activin levels predict poor survival in cancer patients. However, the relative
Adamo, Sergio +8 more
core +1 more source
Skeletal muscle myopenia in mice model of bile duct ligation and carbon tetrachloride-induced liver cirrhosis [PDF]
, 2017 Skeletal muscle myopathy is universal in cirrhotic patients, however, little is known about the main mechanisms involved. The study aims to investigate skeletal muscle morphological, histological, and functional modifications in experimental models of ...
Ascenzi, Francesca +11 more
core +1 more source
Serum Concentrations of Myostatin and Myostatin-Interacting Proteins do not differ between young and Scarcopenic elderly men [PDF]
, 2011 Peer ...
A. DeVries +41 more
core +1 more source
Serum myostatin levels are associated with abdominal aortic calcification in dialysis patients
Kidney Research and Clinical Practice, 2019 Background : Serum myostatin levels are increased according to renal function decline and myostatin may be a main mediator of chronic kidney disease–related sarcopenia.
Su Mi Lee +5 more
doaj +1 more source
Rhabdomyosarcoma: Advances in Molecular and Cellular Biology. [PDF]
, 2015 Rhabdomyosarcoma (RMS) is the most common soft tissue malignancy in childhood and adolescence. The two major histological subtypes of RMS are alveolar RMS, driven by the fusion protein PAX3-FKHR or PAX7-FKHR, and embryonic RMS, which is usually ...
Duan, Zhenfeng +5 more
core +3 more sources
Molecular and Cellular BiochemistryMyostatin, a potent negative regulator of skeletal muscle mass, has garnered significant attention as a therapeutic target for muscle dystrophies.
Brock Wetzlich +2 more
semanticscholar +1 more source