Results 71 to 80 of about 33,582 (263)

Myostatin genotype regulates muscle-specific miRNA expression in mouse pectoralis muscle

BMC Research Notes, 2010
Background Loss of functional Myostatin results in a dramatic increase in skeletal muscle mass. It is unknown what role miRNAs play in Myostatin mediated repression of skeletal muscle mass. We hypothesized that Myostatin genotype would be associated with
Cheng Ye, Rachagani Satyanarayana, Reecy James M   +2 more
doaj   +1 more source

Association between serum GDF-15, myostatin, and sarcopenia in cardiovascular surgery patients

International Journal of Cardiology: Heart & Vasculature, 2022
Background: Myostatin is a negative regulator of skeletal muscle mass. On the other hand, growth differentiation factor (GDF)-15 is associated with lower muscle strength and muscle mass.
Riichi Nishikawa, Taira Fukuda, Akiko Haruyama, Ikuko Shibasaki, Suomi Yamaguchi, Takuo Arikawa, Syotaro Obi, Hirohisa Amano, Hiroshi Yagi, Masashi Sakuma, Shichiro Abe, Hirotsugu Fukuda, Shigeru Toyoda, Toshiaki Nakajima   +13 more
doaj   +1 more source

Systemic Problems: A perspective on stem cell aging and rejuvenation. [PDF]

, 2015
This review provides balanced analysis of the advances in systemic regulation of young and old tissue stem cells and suggests strategies for accelerating development of therapies to broadly combat age-related tissue degenerative pathologies.
CONBOY, Irina M, Conboy, Michael, Rebo, Justin   +2 more
core   +2 more sources

The central role of myostatin in skeletal muscle and whole body homeostasis [PDF]

, 2012
Myostatin is a powerful negative regulator of skeletal muscle mass in mammalian species. It plays a key role in skeletal muscle homeostasis and has now been well described since its discovery.
Allen, Allen, Amirouche, Amthor, Anker, Artaza, Artaza, Bakker, Bernard, Biga, Bish, Bodell, Bodine, Bogdanovich, Burgess, Cai, Castillero, Chen, Chen, Coffey, Costelli, Costelli, Dasarathy, Escobar, Feldman, Fernandez-Celemin, Franckhauser, Frost, Frost, Gentry, George, Goncalves, Gonzalez-Cadavid, Gonzalez-Cadavid, Gonzalez-Freire, Grobet, Gruson, Guo, Guttridge, Hayot, Heinemeier, Hill, Hill, Hirai, Hittel, Hosoyama, Hulmi, Jeanplong, Ji, Jiang, Jones, Kambadur, Kinouchi, Kirk, Kopple, Kraemer, Lang, Lang, Lang, Langen, Langen, Langley, Larsen, Larsen, Lawlor, Lee, Leger, Lehti, Li, Li, Li, Lin, Liu, Liu, Llovera, Lyons, Ma, Manini, Marcell, Mascher, Matsakas, Matsakas, Matzuk, McFarlane, McFarlane, McMahon, McMahon, McPherron, McPherron, McPherron, Megeney, Meienberg, Mendler, Milan, Mitch, Molina, Mosher, Murphy, Nakatani, Nicholas, Nozaki, Ohsawa, Oldham, Peters, Prontera, Ratkevicius, Reardon, Rebbapragada, Rios, Rodgers, Roth, Salehian, Schuelke, Schulte, Seibert, Sharma, Siriett, Southgate, Steffen, Stolz, Swallow, Taylor, Tessitore, Thies, Thomas, Wagner, Wagner, Walker, Weber, Whittemore, Willoughby, Willoughby, Yamaguchi, Yang, Yarasheski, Zachwieja, Zhang, Zhao, Zhu, Zimmers, Zurlo   +140 more
core   +1 more source

The C313Y Piedmontese mutation decreases myostatin covalent dimerisation and stability

BMC Research Notes, 2011
Background Myostatin is a key negative regulator of muscle growth and development, whose activity has important implications for the treatment of muscle wastage disorders.
Starck Carlene S, Sutherland-Smith Andrew J   +1 more
doaj   +1 more source

Dual Action of Dipyridamole in Experimental Rheumatoid Arthritis: Suppression of Joint Inflammation and Upregulation of Muscle Anabolism via Adenosine and AMPK pathways

Arthritis &Rheumatology, Accepted Article.
Introduction Rheumatoid sarcopenia, characterized by the progressive loss of skeletal muscle mass and function, is a frequent comorbidity in rheumatoid arthritis (RA), linked to prolonged, severe systemic inflammation. Purinergic signaling (adenosine, AMP, and ATP) plays a crucial role in inflammation, myogenesis, and muscle hypertrophy.
Miguel Marco‐Bonilla, Maria Fresnadillo, Irene Sanchez‐Platero, Macarena de la Riva‐Bueno, Fernando Huete‐Toral, Gonzalo Carracedo, Carmen Conde, Yolanda Benitez, Pablo Minguez, Sandra Carolina Cifuentes, Joaquin Rams, Gabriel Herrero‐Beaumont, Raquel Largo, Aránzazu Mediero   +13 more
wiley   +1 more source

Inhibition of myostatin signaling through Notch activation following acute resistance exercise. [PDF]

PLoS ONE, 2013
Myostatin is a TGFβ family member and negative regulator of muscle size. Due to the complexity of the molecular pathway between myostatin mRNA/protein and changes in transcription, it has been difficult to understand whether myostatin plays a role in ...
Matthew G MacKenzie, David Lee Hamilton, Mark Pepin, Amy Patton, Keith Baar   +4 more
doaj   +1 more source

p21-Activated Kinase 1 Is Permissive for the Skeletal Muscle Hypertrophy Induced by Myostatin Inhibition

Frontiers in Physiology, 2021
Skeletal muscle, the most abundant tissue in the body, plays vital roles in locomotion and metabolism. Understanding the cellular processes that govern regulation of muscle mass and function represents an essential step in the development of therapeutic ...
Caroline Barbé, Audrey Loumaye, Pascale Lause, Olli Ritvos, Jean-Paul Thissen   +4 more
doaj   +1 more source

Vitamin D, a modulator of musculoskeletal health in chronic kidney disease [PDF]

, 2017
The spectrum of activity of vitamin D goes beyond calcium and bone homeostasis, and growing evidence suggests that vitamin D contributes to maintain musculoskeletal health in healthy subjects as well as in patients with chronic kidney disease (CKD ...
Jordi Bover, Juan J. Carrero, null null, Pablo Molina, Pablo Ureña Torres, Philippe Chauveau, Sandro Mazzaferro   +6 more
core   +2 more sources

Association of serum adiponectin and myostatin levels with skeletal muscle in patients with obesity: A cross-sectional study

PLoS ONE, 2021
Background Adiponectin has been reported to be associated with lower skeletal muscle mass and skeletal strength and may be involved in skeletal muscle regulation along with myostatin.
S. Kurose, Katsuko Onishi, N. Takao, T. Miyauchi, Kazuhisa Takahashi, Y. Kimura   +5 more
semanticscholar   +1 more source