Results 71 to 80 of about 594,131 (308)

Caspase‐3/GSDME‐Mediated Trophoblast Pyroptosis and Reciprocal Macrophage Polarization Contribute to Inflammation in Early‐Onset Preeclampsia

Advanced Science, EarlyView.
In trophoblast cells, T/S (TNFα + SM164) activated caspase‐3, which cleaved GSDME to switch apoptosis to pyroptosis, causing cell swelling, membrane rupture, and release of LDH, HMGB1, IL‐1β and IL‐18. These cytokines induced pro‐inflammatory macrophage polarization, which in turn reinforced pyroptotic signaling in trophoblasts, amplifying systemic ...
Baoying Huang, Weinan Deng, Shilei Bi, Yifan Wang, Zhaowei Tu, Lijun Huang, Lili Du, Lizi Zhang, Zhoushan Feng, Wei Sun, Tengfei Liu, Julia Kzhyshkowska, Haibin Wang, Jingsi Chen, Dunjin Chen, Shuang Zhang   +15 more
wiley   +1 more source

The aesthetics of Harold Pinter's dramatic art [PDF]

Zbornik Radova Filozofskog Fakulteta u Prištini, 2011
The British playwright Harold Pinter (1930-2008) is undoubtedly one of the greatest and most extraordinary modern playwrights, with the writing career which spanned over fifty years.
Šoškić Radoje V.
doaj  

The mystery of the chromosphere [PDF]

, 1996
We discuss many aspects of the solar chromosphere from an observational point of view, and show that most existing models are in direct contradiction to radio and eclipse measurements.
Zirin, Harold
core  

A Non‐Mitophagy Activity of BNIP3L/NIX in Amygdala Glutamatergic Neurons is Essential for Contextual Fear Memory Formation

Advanced Science, EarlyView.
Contextual fear conditioning induces BNIP3L‐dependent mitochondrial fission in glutamatergic neurons of the BLA, independently of mitophagy. Loss of BNIP3L elevates Drp1Ser637 phosphorylation, thereby suppressing mitochondrial fission, compromising ATP production, and attenuating excitatory synaptic transmission.
Xingxian Zhang, Xinlei Mo, Xinyu Zhou, Xiaoliang Liu, Guizhi Li, Songhui Hu, Yangyang Lu, Chenze Zhu, Jinxi Feng, Zhitong Chen, Weiwei Hu, Yihui Cui, Zhong Chen, Xiangnan Zhang   +13 more
wiley   +1 more source

Why Jesus spoke in parables

In die Skriflig, 2019
n the Synoptic Gospels, listeners ask Jesus about the purpose of his parables. These Gospels provide two parallel accounts of this discussion (Mt 13:10–17 // Mk 4:10–12 // Lk 8:9–10 and Mt 13:34–35 // Mk 4:33).
Francois P. Viljoen
doaj   +1 more source

Receptivity to Mystery: Cultivation, Loss, and Scientism [PDF]

, 2012
The cultivation of receptivity to the mystery of reality is a central feature of many religious and philosophical traditions, both Western and Asian. This paper considers two contemporary accounts of receptivity to mystery – those of David E.
Kidd, Ian James
core  

Targeting PRKCN, an Essential Driver Orchestrating mTOR‐IRF4 Axis Independently of Kinase Activity, in Multiple Myeloma

Advanced Science, EarlyView.
Constitutive PRKCN expression is driven by super‐enhancers and modulated by NF‐κB signaling in multiple myeloma (MM). PRKCN activates mTORC1/2‐IRF4 signaling axis and favors tumor cell growth independently of its kinase activity. IRF4 reciprocally promotes PRKCN transcription, creating a feed‐forward loop.
Koukou Tang, Dongpeng Jiang, Peng Ke, Xiaosen Bian, Lili Zhang, Ying Zhang, Tingting Zhu, Weiwei Qu, Wenhui Qi, Yang Xu, Chengcheng Fu, Depei Wu, Jianhong Chu   +12 more
wiley   +1 more source

Illusionismo e magia nel ‘Golden Age Mystery’

Linguae &: Rivista di Lingue e Culture Moderne, 2015
The Golden Age of detective fiction, usually delimitated between 1914 and 1940, coincides with the Golden Age of theatrical magic. Mystery and magic are linked by various elements such as the persistence of the challenge (between writer and readers or ...
Stefano Serafini
doaj   +1 more source

The Highest Energy Cosmic Rays, Gamma Rays and Neutrinos: Facts, Fancy and Resolution

, 2001
Although cosmic rays were discovered 90 years ago, we do not know how and where they are accelerated. There is compelling evidence that the highest energy cosmic rays are extra-galactic -- they cannot be contained by our galaxy's magnetic field anyway ...
Halzen, F.
core   +1 more source

CsdA‐LaeB Regulatory Hub Contributes to Aspergillus fumigatus Virulence via Fumiquinazoline C Biosynthesis

Advanced Science, EarlyView.
This study identifies a conserved CsdA‐LaeB hub in Aspergillus fumigatus that regulates secondary metabolite fumiquinazoline C (FqC). Disrupting this hub enhances FqC production and virulence, shedding new light on the post‐transcriptional regulatory logic linking secondary metabolism to pathogenicity and offering alternative strategies for diagnostic ...
Zili Song, Hongjiao Zhang, Leixin Ye, Yuxin Lei, Linqi Wang, Xiao Liu, Nayanna M. Mercado Soto, Nancy P. Keller, Berl R. Oakley, Can Zhao, Michael Bromley, Hongwei Liu, Lei Cai, Koon Ho Wong, Wen‐Bing Yin   +14 more
wiley   +1 more source