Results 161 to 170 of about 1,029,181 (225)

In vivo metabolism of 5-methoxy-N, N-dimethyltryptamine and N,N-dimethyltryptamine in the rat

Biochemical Pharmacology, 1987
Following intraperitoneal administration, 5-methoxy-N,N-dimethyltryptamine and N,N-dimethyltryptamine are subject to both a very rapid uptake into, and clearance from, all tissues examined. The current studies in vivo confirm previous in vitro observations that the routes involved in the metabolism of these compounds include oxidative deamination, N ...
B R, Sitaram, L, Lockett, R, Talomsin, G L, Blackman, W R, McLeod   +4 more
openaire   +2 more sources

Safety and tolerability of inhaled N,N-Dimethyltryptamine (BMND01 candidate): A phase I clinical trial.

European Neuropsychopharmacology, 2023
Psychedelics are being increasingly examined for their therapeutic potential in mood disorders. While the acute effects of ayahuasca, psilocybin, and lysergic acid diethylamide (LSD) last over several hours, inhaled N,N-Dimethyltryptamine (DMT) effects ...
Marcelo Falchi-Carvalho, Isabel Wießner, S. R. B. Silva, Lucas O． Maia, Handersson Barros, Sophie Laborde, Flávia Arichelle, Sam Tullman, Natan Silva-Costa, Aline Assunção, Raissa Almeida, Érica J. Pantrigo, Raynara Bolcont, José V. Costa-Macedo, Emerson Arcoverde, N. Galvão-Coelho, Dráulio B. Araújo, Fernanda Palhano-Fontes   +17 more
semanticscholar   +1 more source

A new metabolic pathway for N,N-dimethyltryptamine

Biological Psychiatry, 1986
N,N-Dimethyltryptamine (DMT) undergoes a major structural alteration when added to whole human blood or its red blood cells in vitro. A new high-pressure liquid chromatography (HPLC) peak is present in extracts of these treated tissues. The compound responsible for this peak has been identified by ultraviolet spectrophotometry and by mass spectrometry ...
L M, Hryhorczuk, J M, Rainey, C E, Frohman, E A, Novak   +3 more
openaire   +2 more sources

N,N-Dimethyltryptamine: An Endogenous Hallucinogen

1981
Publisher Summary This chapter reviews the biosynthesis, metabolism, pharmacology, and properties of N,N-dimethyltryptamine (DMT), leading to a conclusion that DMT may be a neurotransmitter in the mammalian brain. The identification of DMT and other hallucinogens in man explains the experience of hallucinatory phenomena in general.
S A, Barker, J A, Monti, S T, Christian
openaire   +2 more sources

Biosynthesis and turnover of N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine in Phalaris tuberosa

Phytochemistry, 1972
Abstract The biosynthesis and turnover of N , N -dimethyltryptamine and 5-methoxy- N , N -dimethyltryptamine have been studied in the pasture grass Phalaris tuberosa by a combination of feeding and trapping experiments using radioisotopically labelled compounds. Their turnover has been demonstrated by feeding tryptophan and tryptamine.
Claire Baxter, M. Slaytor
openaire   +1 more source

Neuromodulatory mechanisms of N,N-dimethyltryptamine

Brain Network and Modulation, 2023
N,N-dimethyltryptamine (DMT) is the simplest psychedelic tryptamine and is produced naturally by many plant and animal species, including humans. While classical psychedelics, such as lysergic acid diethylamide, or psilocybin, are gaining interest because of their therapeutic potential, DMT has yet to be fully investigated ...
openaire   +1 more source

Studies on several 7-substituted N,N-dimethyltryptamines

Journal of Medicinal Chemistry, 1980
Several 7-substituted derivatives of N,N-dimethyltryptamine (DMT) were prepared and evaluated in the rat fundus serotonin receptor assay and in a behavioral (discriminative stimulus) assay in rats. Both 7-Me- and 5-OMe-7-Me-DMT possess a higher pA2, and 5,7-(OMe)2-DMT a lower pA2, than that of DMT itself.
R A, Glennon, E, Schubert, J M, Jacyno, J A, Rosecrans   +3 more
openaire   +2 more sources

N,N-dimethyltryptamine like substance in rat brain

Life Sciences, 1973
Abstract Rat brain contains 8 μg/g of a tertiary amine, very probably N,N-dimethyltryptamine as shown by bidimensional thin layer and gas ohromatography. Pretreatment with Nialamide did not modify the concentration of this substance in the brain.
B, Heller, E, Fischer, H, Spats
openaire   +2 more sources

Human psychopharmacology of N,N-dimethyltryptamine

Behavioural Brain Research, 1995
We generated dose-response data for the endogenous and ultra-short-acting hallucinogen, N,N-dimethyltryptamine (DMT), in a cohort of experienced hallucinogen users, measuring multiple biological and psychological outcome measures. Subjective responses were quantified with a new rating scale, the HRS, which provided better resolution of dose effects ...
openaire   +2 more sources

Hydroxylation and N-demethylation of N,N-dimethyltryptamine

Experientia, 1959
Der intermediare Stoffwechsel des psychotropen N,N-Dimethyltryptamins wurde untersucht. N-Methyltryptamin, als Produkt der Demethylierung, und 6-Hydroxy-N,N-Dimethyltryptamin, als Produkt der Hydroxylierung, wurden nachgewiesen und papierchromatographisch charakterisiert.
S, SZARA, J, AXELROD
openaire   +2 more sources