Results 151 to 160 of about 10,565,775 (206)

A comparison of the behavioral effects of proteo- and deutero-N, N-dimethyltryptamine

Pharmacology Biochemistry and Behavior, 1982
The behavioral effects of N,N-dimethyltryptamine (DMT) and α, α, β, β-tetradeutero-N,N-dimethyltryptamine (D4DMT) at dose levels of 2.5 and 5.0 mg/kg were examined in rats on a food reinforced schedule. The D4DMT was observed to produce a significantly greater disruption of behavior, have a longer duration of action and a shorter time to onset than DMT.
Wu-Fu Liu, W F Liu
exaly   +3 more sources

Neural and subjective effects of inhaled N,N-dimethyltryptamine in natural settings [PDF]

Journal of Psychopharmacology, 2021
Background: N,N-dimethyltryptamine is a short-acting psychedelic tryptamine found naturally in many plants and animals. Few studies to date have addressed the neural and psychological effects of N,N-dimethyltryptamine alone, either administered ...
Carla Pallavicini, Christopher Timmermann, Alethia De La Fuente   +2 more
exaly   +2 more sources

Parapsychology, N, N-Dimethyltryptamine and the Pineal Gland [PDF]

, 2019
In the last decades, one of the psychedelic substances which has gained high attention for its implications in several para-psychological phenomena (including out-of-body states, deep changes in sensory perception, mood, and thought, travels in" hyperspace", and meetings with disincarnate entities, as well as other" breakthrough experiences") is ...
Bragazzi, Nicola Luigi, Khabbache, Hicham, Perduca, Marco, Neri, Bruno, Firenzuoli, Fabio, Penazzi, Gabriele, Simões, Mário, Zerbetto, Riccardo, Re, Tania Simona   +8 more
openaire   +2 more sources

“In vivo biosynthesis of N,N-dimethyltryptamine, 5-MeO-N,N-dimethyltryptamine, and bufotenine in E. coli”

Metabolic Engineering, 2023
N,N-dimethyltryptamine (DMT), 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) and 5-hydroxy-N,N-dimethyltryptamine (bufotenine) are psychedelic tryptamines found naturally in both plants and animals and have shown clinical potential to help treat mental disorders, such as anxiety and depression.
Lucas M. Friedberg, Abhishek K. Sen, Quynh Nguyen, Gabriel P. Tonucci, Elle B. Hellwarth, William J. Gibbons, J. Andrew Jones   +6 more
openaire   +2 more sources

In vivo metabolism of 5-methoxy-N, N-dimethyltryptamine and N,N-dimethyltryptamine in the rat

Biochemical Pharmacology, 1987
Following intraperitoneal administration, 5-methoxy-N,N-dimethyltryptamine and N,N-dimethyltryptamine are subject to both a very rapid uptake into, and clearance from, all tissues examined. The current studies in vivo confirm previous in vitro observations that the routes involved in the metabolism of these compounds include oxidative deamination, N ...
B R, Sitaram, L, Lockett, R, Talomsin, G L, Blackman, W R, McLeod   +4 more
openaire   +2 more sources

N,N-Dimethyltryptamine–Induced Psychosis

Clinical Neuropharmacology, 2015
N,N-dimethyltryptamine (DMT) is a 5-hydroxytryptamine 2A and 1A receptor agonist that exhibits potent psychoactive properties in humans. Recreational use of this drug has increased precipitously and is likely to result in an increase in patients presenting with substance-induced psychoses. The present case provides an early example of substance-induced
Neil E, Paterson, W Connor, Darby, Preetpal S, Sandhu   +2 more
openaire   +2 more sources

N,N-Dimethyltryptamine: An Endogenous Hallucinogen

1981
Publisher Summary This chapter reviews the biosynthesis, metabolism, pharmacology, and properties of N,N-dimethyltryptamine (DMT), leading to a conclusion that DMT may be a neurotransmitter in the mammalian brain. The identification of DMT and other hallucinogens in man explains the experience of hallucinatory phenomena in general.
S A, Barker, J A, Monti, S T, Christian
openaire   +2 more sources

A new metabolic pathway for N,N-dimethyltryptamine

Biological Psychiatry, 1986
N,N-Dimethyltryptamine (DMT) undergoes a major structural alteration when added to whole human blood or its red blood cells in vitro. A new high-pressure liquid chromatography (HPLC) peak is present in extracts of these treated tissues. The compound responsible for this peak has been identified by ultraviolet spectrophotometry and by mass spectrometry ...
L M, Hryhorczuk, J M, Rainey, C E, Frohman, E A, Novak   +3 more
openaire   +2 more sources

Neuromodulatory mechanisms of N,N-dimethyltryptamine

Brain Network and Modulation, 2023
N,N-dimethyltryptamine (DMT) is the simplest psychedelic tryptamine and is produced naturally by many plant and animal species, including humans. While classical psychedelics, such as lysergic acid diethylamide, or psilocybin, are gaining interest because of their therapeutic potential, DMT has yet to be fully investigated ...
openaire   +1 more source

Hydroxylation and N-demethylation of N,N-dimethyltryptamine

Experientia, 1959
Der intermediare Stoffwechsel des psychotropen N,N-Dimethyltryptamins wurde untersucht. N-Methyltryptamin, als Produkt der Demethylierung, und 6-Hydroxy-N,N-Dimethyltryptamin, als Produkt der Hydroxylierung, wurden nachgewiesen und papierchromatographisch charakterisiert.
S, SZARA, J, AXELROD
openaire   +2 more sources