Results 171 to 180 of about 1,029,181 (225)

Examining the pharmacokinetic and pharmacodynamic interaction of N,N-dimethyltryptamine and harmine in healthy volunteers: Α factorial dose-escalation study.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Ayahuasca, a traditional psychoactive Amazonian brew, usually contains N,N-dimethyltryptamine (DMT) and β-carboline (harmine, harmaline, tetrahydroharmine) monoamine oxidase inhibitors.
K. Egger, Javier Jareño Redondo, Jovin Müller, Joëlle Dornbierer, John W. Smallridge, H. Aicher, D. Meling, Per Müller, Jonas Kost, Maxim Puchkov, Angela Äbelö, Erich Seifritz, B. Quednow, R. von Rotz, M. Scheidegger, Dario Dornbierer   +15 more
semanticscholar   +1 more source

Significance of mammalian N, N-dimethyltryptamine (DMT): A 60-year-old debate

Journal of Psychopharmacology, 2022
N,N-dimethyltryptamine (DMT) is a potent psychedelic naturally produced by many plants and animals, including humans. Whether or not DMT is significant to mammalian physiology, especially within the central nervous system, is a debate that started in the
Javier Hidalgo Jiménez, José Carlos Bouso   +1 more
semanticscholar   +1 more source

[Elimination of N,N-dimethyltryptamine by urine].

Acta psiquiatrica y psicologica de America latina, 1994
N,N-dimethiltryptamine (DMT) in urine has been quantified on an 83-psychiatric patient sample. Sample covered patients who had sometimes been administered neuroleptic drugs as well as patients with some particular symptomatology associated to psychotic disorders such as hallucinations, delusions, perception disorders, etc. 43.3% (36 cases) evidenced an
N, Spatz, H, Spatz, H L, Mesones Arroyo, T, Rosan, F, Brengio   +4 more
openaire   +2 more sources

Phase 1, placebo-controlled, single ascending dose trial to evaluate the safety, pharmacokinetics and effect on altered states of consciousness of intranasal BPL-003 (5-methoxy-N,N-dimethyltryptamine benzoate) in healthy participants

Journal of Psychopharmacology
Aims: To investigate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of BPL-003, a novel intranasal benzoate salt formulation of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT), in healthy participants.
James J Rucker, C. Roberts, M. Seynaeve, Allan H Young, B. Suttle, Takahiro Yamamoto, A.O. Ermakova, Fiona Dunbar, F. Wiegand   +8 more
semanticscholar   +1 more source

Effects of N,N-Dimethyltryptamine (DMT) and 5-Methoxy-N,N-dimethyltryptamine (5-MeODMT) on shock elicited fighting in rats

Pharmacology Biochemistry and Behavior, 1978
Rats were tested for shock elicited fighting under various doses of N,N-dimethyltryptamine (0.12, 0.25, 0.50, 1.0, 4.0, 8.0 mg/kg) and 5-methoxy-N,N-dimethyltryptamine (0.06, 0.12, 0.5, 2.0 mg/kg). Both drugs produced an inhibition of fighting at higher doses but no significant effects at lower doses.
J K, Walters, M H, Sheard, M, Davis
openaire   +2 more sources

The Psilocin (4‐hydroxy‐N,N‐dimethyltryptamine) and Bufotenine (5‐hydroxy‐N,N‐dimethyltryptamine) Case: Ensuring the Correct Isomer has Been Identified

Journal of Forensic Sciences, 2020
AbstractPsilocin (4‐hydroxy‐N,N‐dimethyltryptamine, 4‐HO‐DMT) and bufotenine (5‐hydroxy‐N,N‐dimethyltryptamine, 5‐HO‐DMT), which are both naturally occurring compounds, are classified as controlled substances in numerous countries due to their pharmacological activities and recreational usage.
Tehila, Mishraki-Berkowitz, Esti, Kochelski, Pierce, Kavanagh, John, O'Brien, Clodagh, Dunne, Brian, Talbot, Patricia, Ennis, Udi Ehud, Wolf   +7 more
openaire   +2 more sources

N, N-dimethyltryptamine (DMT) in rodent brain: Concentrations, distribution, and recent pharmacological data.

Progress in Neuro-psychopharmacology and Biological Psychiatry
Renewed interest in the clinical use of psychedelic drugs acknowledges their therapeutic effectiveness. It has also provided a changing frame of reference for older psychedelic drug study data, especially regarding concentrations of N, N ...
Steven A Barker
semanticscholar   +1 more source

PHARMACOKINETICS OF N,N-DIMETHYLTRYPTAMINE FUMARATE IN HUMANS

2022
Aim: N,N-dimethyltryptamine (DMT) is a psychedelic compound under development for the treatment of major depressive disorder (MDD). This study evaluated the in vitro metabolism and clinical pharmacokinetics (PK) of DMT fumarate (SPL026) in healthy subjects.
Meghan Good, Tiffanie Benway, Zelah Joel, Carol Routledge, Christopher Timmermann, David Erritzoe, Richard Weaver, Graham Allen, Charlotte Hughes, Helen Topping, Ellen James   +10 more
openaire   +1 more source

Time-resolved Neural and Experience Dynamics of Medium- and High-dose N,N-Dimethyltryptamine.

Journal of Cognitive Neuroscience
N,N-dimethyltryptamine (DMT) is a fast-acting psychedelic drug that induces a radical reorganization of conscious contents and brain dynamics. However, our understanding of how brain dynamics support psychedelic-induced conscious states remains unclear ...
Evan Lewis-Healey, Carla Pallavicini, F. Cavanna, T. D’Amelio, L. A. de la Fuente, Débora Copa, Stephanie Müller, Nicolás Bruno, E. Tagliazucchi, T. Bekinschtein   +9 more
semanticscholar   +1 more source

Analysis of N,N‐dimethyltryptamine (DMT) and its metabolites using LC–MS/MS for forensic purposes

Journal of Forensic Sciences
Ayahuasca contains N,N‐dimethyltryptamine (DMT), the primary alkaloid responsible for its psychedelic effects. DMT oxidative deamination yields indole‐3‐acetic acid (IAA) as the predominant metabolite, while N‐oxidation produces N,N‐dimethyltryptamine‐N ...
Munchelou M. Gomonit, Madeleine J. Swortwood, M. Truver, Britni N Skillman   +3 more
semanticscholar   +1 more source