Results 181 to 190 of about 1,029,181 (225)

Liquid chromatography-tandem mass spectrometry method for the bioanalysis of N,N-dimethyltryptamine (DMT) and its metabolites DMT-N-oxide and indole-3-acetic acid in human plasma.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2022
The indole alkaloid N,N-dimethyltryptamine (DMT) induces psychedelic effects in humans. In addition to ceremonial and recreational use, DMT is subject to clinical investigations. Sensitive bioanalytical methods are required to assess the pharmacokinetics
D. Luethi, Karolina E. Kolaczynska, S. Vogt, L. Ley, L. Erne, M. Liechti, Urs Duthaler   +6 more
semanticscholar   +1 more source

Increased synthesis of striatal dopamine by N,N-dimethyltryptamine

Life Sciences, 1977
Abstract The effect of acute doses of N,N-dimethyltryptamine (DMT) on the synthesis or degradation rates of rat diencephalon norepinephrine and striatal dopamine was estimated by administering 150 μCi L-tyrosine-3,5- 3 H at various times before sacrifice. In all cases DMT, 20 mg/kg, was injected one-half hour before sacrifice.
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Relative potency of amphetamine derivatives and N,N-dimethyltryptamines

Psychopharmacologia, 1971
The relative potency of amphetamine derivatives and N,N-dimethyltryptamine (DMT) derivatives was evaluated in rats trained to swim through an underwater tube in order to escape at the other and of the tank. All of the compounds tested significantly increased the starting latency.
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Opposite effects of N,N-dimethyltryptamine (DMT) and 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) on acoustic startle: Spinal vs brain sites of action

Neuroscience & Biobehavioral Reviews, 1982
The present studies examined the role of the spinal cord and the brain in mediating the effects of the hallucinogens N,N-dimethyltryptamine (DMT) and 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) on the acoustic startle response in the rat. Systemic administration of these agents, which distributes to both the brain and spinal cord, produced opposite ...
R L, Commissaris, M, Davis
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Endogenous Biosynthesis and Neural Correlates of N,N-dimethyltryptamine

2023
N,N-dimethyltryptamine (DMT) belongs to a class of drugs known as serotonergic psychedelics, which produce profound shifts in consciousness by dramatically altering perception and causing hallucinatory phenomena. In humans, DMT has a rapid onset and the effects, which include feelings of dissociation from external reality, entering into an ...
openaire   +2 more sources

Effects of 5-methoxy-N,N-dimethyltryptamine on central monoamine neurons

European Journal of Pharmacology, 1972
Abstract Using α-propyldopacetamide (H 22/54), a tryptophan hydroxylase inhibitor, and α-methyltyrosine methylester (H 44/68), a tyrosine hydroxylase inhibitor, the effects of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) on amine turnover in central 5-HT, NA and DA nerve terminals of the rat were studied using histochemical fluorescence methods for ...
K, Fuxe, B, Holmstedt, G, Jonsson
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Metabolism of the hallucinogen N,N-dimethyltryptamine in rat brain homogenates

Biochemical Pharmacology, 1980
Abstract The metabolism of the hallucinogen N , N -dimethyltryptamine (DMT) in whole rat brain homogenate is reported. Studies were conducted using tritiated DMT and DMT- N -oxide (DMT-NO), and metabolites were identified and quantified using thin-layer chromatography and liquid scintillation counting techniques. Metabolite confirmation was obtained
S A, Barker, J A, Monti, S T, Christian
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The psychedelic model of schizophrenia: the case of N,N- dimethyltryptamine

American Journal of Psychiatry, 1976
The authors review the research on N,N-dimethyltryptamine (DMT) as a possible "schizotoxin." DMT produces psychedelic effects when administered to normal subjects, the means are present to synthesize it in man, it has occasionally been found in man, and tolerance to its behavioral effects is incomplete.
J C, Gillin, J, Kaplan, R, Stillman, R J, Wyatt   +3 more
openaire   +2 more sources

N,N-Dimethyltryptamine: DMT-induced psychosis

The American Journal of Emergency Medicine, 2020
David, Barbic, Justin, Fernandes, Caroline, Eberdt, Apu, Chakraborty   +3 more
openaire   +2 more sources

Identification of N,N-dimethyltryptamine, 5-methoxy-N,N-dimethyltryptamine and bufotenin by cellulose TLC

Journal of Chromatography A, 1973
P, Baumann, , Narasimhachari
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