Results 71 to 80 of about 37,494,510 (234)
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
This dataset contains experimental data from a sample (N-(3-bromophenyl)acetamide, InChI=1S/C8H8BrNO/c1-6(11)10-8-4-2-3-7(9)5-8/h2-5H,1H3,(H,10,11)).
Wippert, Nicolai
core +1 more source
Número 3. Diciembre 2014 Presentación del número 3. Graciela H. Tonon El nacionalismo en los Balcanes. La creación de naciones a un alto precio. Horacio Sánchez Mariño.
Graciela Tonon
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Tuumorispesifisen aldehydidehydrogenaasi-3:n alueellinen ilmentyminen maksassa
Tuumorispesifinen aldehydidehydrogenaasi, ALDH-3, ilmentyy jyrsijän maksassa karsinogeenialtistuksen jälkeen. ALDH3 kuuluu myös vierasaine-aineenvaihduntaan osallistuvien geenituotteiden ryhmään, joiden ilmentymän säätely välittyy ns. Ah (aryylihiilivety)
Järveläinen, Harri
core
Editorial (RDPDF, vol. 3, n. 3, 2021)
A Revista da Defensoria Pública do Distrito Federal (RDPDF) apresenta o terceiro número de 2021, composto por artigos que se debruçaram sobre o dossiê temático “Violência e direito: discussões teóricas e práxis”. Concretizando o objetivo institucional
Alberto Carvalho Amaral
doaj
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Ato n. 168/GP, de 3 de abril de 2014
Altera a redação do art. 2º, do art. 3º e seu § 1º e do § 1º do art. 6º do Ato n. 786/GP, de 3 de dezembro de 2012, que institui o Sistema de Gestão Estratégica do Tribunal Superior do Trabalho (SIGEST).Determina a republicação do Ato n.
Brasil. Tribunal Superior do Trabalho (TST)
core
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source

