Results 61 to 70 of about 14,619 (195)

The Role of Magnetic Resonance Spectroscopy (MRS), Diffusion‐Tensor‐Imaging (DTI) and Structural MRI in the Alzheimer's Disease and Mild Cognitive Impairment Diagnosis: A Review

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Alzheimer's disease (AD) is one of the most common neurological disorders affecting older adults, with approximately 7.2 million cases only in the United States. This number is projected to increase to 13.8 million in the United States by 2060, leading to increased expenditures for healthcare, long‐term care and hospice services. Consequently,
Valentina Zecca, Gianmauro Palombelli, Nicola Vanacore, Rossella Canese   +3 more
wiley   +1 more source

N-acetylaspartate complexes with calcium and lanthanide ions

Journal of Inorganic Biochemistry, 1995
N-acetylaspartate (NAA) is the one of the most prominent resonances observed in the solvent-suppressed NMR spectrum of the human brain. Although it is present in the brain at about 10 mM, its precise metabolic function is still unclear, We have examined the NAA as a potential chelator for divalent metal ions such as Ca2+.
Y, Rubin, G P, Connelly, R E, Lenkinski
openaire   +2 more sources

N-acetyl-aspartate and Myo-inositol as Markers of White Matter Microstructural Organization in Mild Cognitive Impairment: Evidence from a DTI-¹H-MRS Pilot Study

Diagnostics, 2023
We implemented a multimodal approach to examine associations between structural and neurochemical changes that could signify neurodegenerative processes related to mild cognitive impairment (MCI).
Kristina Valatkevičienė, Oron Levin, Milda Šarkinaitė, Wouter A. J. Vints, Rimantė Kunickaitė, Greta Danylė, Simona Kušleikienė, Samrat Sheoran, Vida J. Česnaitienė, Nerijus Masiulis, Uwe Himmelreich, Rymantė Gleiznienė   +11 more
doaj   +1 more source

Exploratory 7-Tesla magnetic resonance spectroscopy in Huntington’s disease provides in vivo evidence for impaired energy metabolism [PDF]

, 2011
Neurological Motor ...
Simon J. A. den Bogaard, Eve M. Dumas, Wouter M. Teeuwisse, Hermien E. Kan, Andrew Webb, Raymund A. C. Roos, Jeroen Grond   +6 more
core   +1 more source

Spectral Representation of Neurochemicals With Phase, Frequency Offset, and Lineshape Invariance: Application to JPRESS for In Vivo Concentration and T2 Mapping by Deep Learning

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Using artificial intelligence neural networks to generate a representation that maps the input directly to neurochemical concentrations and metabolite‐level average transverse relaxation times (T2). Methods The proposed model used time‐domain JPRESS data as input and was trained to be invariant to phase shifts, frequency offsets, and ...
Yan Zhang, Jun Shen
wiley   +1 more source

Metabolite differences between glutamate carboxypeptidase II gene knockout mice and their wild-type littermates after traumatic brain injury: a 7-tesla 1H-MRS study

BMC Neuroscience, 2018
Background Traumatic brain injury (TBI) is a complex condition and remains a prominent public and medical health issue in individuals of all ages. A rapid increase in extracellular glutamate occurs after TBI, leading to glutamate-induced excitotoxicity ...
Wenbo Wu, Siyi Xu, Jialin Wang, Kuiming Zhang, Mingkun Zhang, Yang Cao, Hongqing Ren, Deyou Zheng, Chunlong Zhong   +8 more
doaj   +1 more source

Hypoglutamatergic activity in the STOP knockout mouse: a potential model for chronic untreated schizophrenia.: 13C study of metabolism in STOP KO mice [PDF]

, 2007
International audienceIn mice, the deletion of the STOP protein leads to hyperdopaminergia and major behavioral disorders that are alleviated by neuroleptics, representing a potential model of schizophrenia.
Andrieux, Annie, Brenner, Eiliv, Nehlig, Astrid, Schweitzer, Annie, Sonnewald, Ursula   +4 more
core   +3 more sources

Effect of Water Suppression and Metabolite Cycling on Quantification of 1H MRS Spectra in the Human Brain at 3 Tesla

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose This study investigates the effect of VAPOR water suppression and metabolite cycling on metabolite quantification and macromolecules in proton magnetic resonance spectroscopy. Methods Single‐voxel semi‐LASER spectra (TR/TE = 3000/28 ms) and metabolite‐nulled spectra (macromolecules) were acquired in five healthy subjects in the ...
Dinesh K. Deelchand, Pierre‐Gilles Henry   +1 more
wiley   +1 more source

Associations of cannabis use, tobacco use and co‐use with brain volume: A systematic review and meta‐analysis

Addiction, EarlyView.
Abstract Background and aims Cannabis is the most widely used illicit drug worldwide and is often co‐used with tobacco, the leading cause of preventable death. Although cannabis and tobacco have distinct neurobiological actions, their associations with brain volumes are unclear.
Katherine Sawyer, Tom P. Freeman, Martine Skumlien, Esther Walton, Thomas Lancaster, Jorien L. Treur, Valentina Lorenzetti, Anna K. M. Blackwell, Chloe Burke, Richie J. Carr, Constantinos Constantinides, Maisie Cox, Sarah Dance, Shadi Daryan, Sorcha Hamilton, Tom Jenkins, Gemma M. J. Taylor   +16 more
wiley   +1 more source

Inhibition of N-acetylaspartate production

NeuroReport, 1996
The effect of specific irreversible inhibitors of complexes I, III, IV and V of the mitochondrial respiratory chain, (rotenone, myxothiazol, cyanide and oligomycin, respectively) on mitochondrial N-acetylaspartate production, and its relationship to oxidative phosphorylation (ATP production and oxygen consumption) were investigated in isolated rat ...
Timothy Bates, Maria Strangward, Julia Keelan, Gavin P. Davey, Peter M. G. Munro, John B. Clark   +5 more
openaire   +2 more sources