Results 71 to 80 of about 14,619 (195)

N-Acetylaspartate in the CNS: From neurodiagnostics to neurobiology [PDF]

Progress in Neurobiology, 2007
The brain is unique among organs in many respects, including its mechanisms of lipid synthesis and energy production. The nervous system-specific metabolite N-acetylaspartate (NAA), which is synthesized from aspartate and acetyl-coenzyme A in neurons, appears to be a key link in these distinct biochemical features of CNS metabolism.
Moffett, John R, Ross, Brian, Arun, Peethambaran, Madhavarao, Chikkathur N, Namboodiri, Aryan M. A.   +4 more
openaire   +2 more sources

Magnetic Resonance Spectroscopy in Neurofibromatosis

Pediatric Neurology Briefs, 1999
The functional significance of T2 hyperintense lesions (UBOs) and their role in learning disabilities associated with neurofibromatosis type 1 (NF-1) were studied by quantitative magnetic resonance spectroscopy (MRS) in 7 male patients, aged 6-19 years ...
J Gordon Millichap
doaj   +1 more source

A Cerebellar High-Grade Neuroepithelial Tumour with BCOR Alteration in a five-year-old Child: A case report. [PDF]

, 2019
New groups of high-grade neuroepithelial tumours (HGNET) have emerged from the reclassification of central nervous system (CNS) embryonal tumours that have recognised CNS HGNET with BCOR alteration (CNS HGNET-BCOR).
Al Hajri, Zahra, Al-Battashi, Abeer, Al-Ghaithi, Ibrahim, Al-Kindi, Hunaina, Perry, Arie   +4 more
core   +1 more source

Combining Double Fluorescence In Situ Hybridization with Immunolabelling for Detection of the Expression of Three Genes in Mouse Brain Sections [PDF]

, 2016
Detection of gene expression in different types of brain cells e.g., neurons, astrocytes, oligodendrocytes, oligodendrocyte precursors and microglia, can be hampered by the lack of specific primary or secondary antibodies for immunostaining.
Fudge, A, Jolly, S, Li, H, Pringle, N, Richardson, WD   +4 more
core   +1 more source

Methodological comparison of fetal brain 1H‐MRS data analysis techniques and gestational age analysis using LCModel in the fetal sheep brain

Experimental Physiology, EarlyView.
Abstract Proton (1H) magnetic resonance spectroscopy (MRS) is a non‐invasive imaging technique that can be used to assess brain metabolism. Establishing reference levels of fetal brain metabolites in a translatable preclinical model is crucial for identifying subtle deviations from normal cerebral development. Herein, we developed a 1H‐MRS protocol for
Jordan A. Minns, Jack R. T. Darby, Georgia K. Williams, Jesse T. Tu, Ziqi Sun, Jessie Guo, Steven P. Miller, Christopher K. Macgowan, Mike Seed, Jamie Near, Janna L. Morrison   +10 more
wiley   +1 more source

Proton magnetic resonance spectroscopy of neurometabo­lites in the hippocampi of aggressive and tame male rats

Вавиловский журнал генетики и селекции, 2015
Proportions of major neurometabolites with regard to their total amount in the dorsal region of the hippocampus were studied in adult male rats of populations selected for long for increase and absence of aggressivefearful response to humans and in ...
R. G. Gulevich, A. E. Akulov, S. G. Shikhevich, R. V. Kozhemyakina, I. Z. Plyusnina   +4 more
doaj   +1 more source

Stabilized low-n amyloid-ß oligomers induce robust novel object recognition deficits associated with inflammatory, synaptic, and GABAergic dysfunction in the rat [PDF]

, 2017
YesBackground:With current treatments for Alzheimer’s disease (AD) only providing temporary symptomatic benefits, disease modifying drugs are urgently required. This approach relies on improved understanding of the early pathophysiology of AD.
Akkerman, Bouter, Brady, Brouillette, Chen, Cheng, Cohen, Daniels, Desbene, Domek-Lopacinska, Figueiredo, Garcia, Garcia-Osta, Gong, Goutagny, Grayson, Grayson, Griffin, Harte, Jarosz-Griffiths, Lacor, Lai, Lesné, Martinez, Matsumura, McKibben, McLean, McLean, McLean, Ono, Paxinos, Rosales-Corral, Satoh, Selkoe, Shaftel, Shankar, Snigdha, Sohal, Taguchi, Townsend, Verret, Wang, Warburton, Youssef   +43 more
core   +2 more sources

Simultaneous Detection of GABA and Glycine Using MEGA‐PRESS With TE Optimization at 3T

Magnetic Resonance in Medicine, Volume 95, Issue 5, Page 2479-2488, May 2026.
ABSTRACT Purpose To achieve the simultaneous acquisition of gamma‐aminobutyric acid (GABA) and glycine (Gly) using a MEGA‐PRESS sequence with an optimized TE at 3T. Methods MEGA‐PRESS simulations were performed at TEs 60‐88 ms to determine the optimal TE for Gly detection with minimal myo‐Inositol (mI) overlap and maximal GABA detection sensitivity ...
Justin R. Singer, Kimberly L. Chan
wiley   +1 more source

Evidence for distinct neuro-metabolic phenotypes in humans

NeuroImage, 2022
Advances in magnetic resonance imaging have shown how individual differences in the structure and function of the human brain relate to health and cognition.
Bofan Wu, Andrew P. Bagshaw, Clayton Hickey, Simone Kühn, Martin Wilson   +4 more
doaj   +1 more source

Oligodendrocytes Do Not Export NAA-Derived Aspartate In Vitro. [PDF]

, 2016
Oligodendroglial cells are known to de-acetylate the N-acetylaspartate (NAA) synthesized and released by neurons and use it for lipid synthesis. However, the role of NAA regarding their intermediary metabolism remains poorly understood.
AC Yu, AF D’Adamo Jr, AI Amaral, AI Amaral, AI Amaral, Ana I. Amaral, AS Baer, C Mazzoccoli, CN Madhavarao, CN Madhavarao, CN Madhavarao, D Attwell, EB Sherry, G Chakraborty, HH Tallan, I Tkáč, IY Choi, JD Cahoy, JE Rinholm, JR Moffett, JR Moffett, JR Moffett, JR Moffett, JR Moffett, JV Nadler, JW Geddes, K Biemann, Mark Kotter, MC McKenna, MD Norenberg, MD Norenberg, MH Baslow, MH Baslow, MH Baslow, ML Simmons, ML Wynn, Mussie Ghezu Hadera, PM Long, PS Ariyannur, S Kumar, S Signoretti, S Zaroff, SL Miller, TB Patel, TE Bates, TP Mawhinney, U Funfschilling, Ursula Sonnewald, W Liu, Y Zhang   +49 more
core   +2 more sources