A common polymorphism associated with antibiotic-induced cardiac arrhythmia [PDF]
, 2000 Drug-induced long QT syndrome (LQTS) is a prevalent disorder of uncertain etiology that predisposes to sudden death. KCNE2 encodes MinK-related peptide 1 (MiRP1), a subunit of the cardiac potassium channel I(Kr) that has been associated previously with ...
F. Sesti +9 more
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Mechanisms of drug-induced lupus. IV. Comparison of procainamide and hydralazine with analogs in vitro and in vivo [PDF]
, 1997 Objective . T cells treated with DNA methylation inhibitors overexpress lymphocyte function-associated antigen 1 (LFA-1), which results in autoreactivity, and the autoreactive cells cause a lupus-like disease in vivo, suggesting a mechanism by which some
Chang, Sandra +4 more
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N-Acetylprocainamide: An Active Metabolite of Procainamide
Experimental Biology and Medicine, 1974 SummaryN-Acetylprocainamide has been detected in the plasma samples of each of four patients receiving procainamide. The metabolite was identified from tlc data and its identity confirmed by gas chomatographic-mass spectroscopic analysis. The metabolite was also detected in the whole blood of Sprague-Dawley rats after administration of PA.
D E, Drayer, M M, Reidenberg, R W, Sevy
openaire +2 more sources
Electrochemistry-on-chip for on-line conversions in drug metabolism studies [PDF]
, 2010 We have designed an integrated 3-electrode electrochemical cell on-chip with high analyte conversion rates for use in drug metabolism studies. The electrochemical cell contains platinum working and counter electrodes and an iridium oxide pseudo-reference
Baumann, A. +4 more
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UK-68,798, A Class III Antiarrhythmic Drug with Antifibrillatory Properties [PDF]
, 1992 Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/74787/1/j.1527-3466.1992.tb00244.x ...
Balser JR +26 more
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CD4+ cells treated with DNA methylation inhibitors induce autologous B cell differentiation [PDF]
, 1990 The DNA methylation inhibitor 5-azacytidine induces autoreactivity in cloned CD4+ T cells, but the functional consequences of this response are unknown.
Akbar +42 more
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Manejo de las intoxicaciones agudas [PDF]
, 2013 La toxicología clínica es la parte de la toxicología general que se ocupa del diagnóstico y tratamiento de las intoxicaciones en su amplio sentido.
Bretones Sánchez, Cristina
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Cardiovascular drugs inducing QT prolongation: facts and evidence [PDF]
, 2010 Acquired QT syndrome is mainly caused by the administration of drugs that prolong ventricular repolarization. On the other hand, the risk of drug-induced torsades de pointes is increased by numerous predisposing factors, such as genetic predisposition ...
Höcht, Christian +3 more
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Interrelationships between serum levels of amiodarone, desethylamiodarone, reverse T3 and the QT interval during long-term amiodarone treatment [PDF]
, 1986 The interrelationships between serum levels of amiodarone, desethylamiodarone, and reverse T3, and changes in the corrected QT interval ([Delta]QTc) were examined in 22 patients during long-term treatment with amiodarone.
Annesley, Thomas M. +6 more
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Alternative Pharmacokinetic Models in End Stage Renal Disease During Continuous Ambulatory Peritoneal Dialysis [PDF]
, 1987 An important principle of pharmacokinetic modeling is to use the least complicated model possible that adequately describes the process studied.
Cefali, Eugenio
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