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A chemosensor to recognize N-acyl homoserine lactone in bacterial biofilm
Sensors and Actuators B: Chemical, 2018Abstract A simple, sensitive, and rapid assay has been developed for detection of N-acyl homoserine lactone (HSL) autoinducers involved in bacterial quorum sensing (QS) by a new coumarin appended rhodamine derivative (RNC) ensembled with Cu2+. RNC-Cu2+ conjugate shows “turn on” fluorescence while binding with HSLs.
Sujoy Das +4 more
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Detection of bacterial quorum sensing N-acyl homoserine lactones in clinical samples
Analytical and Bioanalytical Chemistry, 2008Bacteria communicate among themselves using certain chemical signaling molecules. These signaling molecules generally are N-acyl homoserine lactones (AHLs) in Gram-negative bacteria and oligopeptides in Gram-positive bacteria. In addition, both Gram-positive and Gram-negative bacteria produce a family of signaling molecules known as autoinducer-2 that ...
Anjali, Kumari +2 more
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QSAR MODEL OF THE QUORUM-QUENCHING N-ACYL-HOMOSERINE LACTONE LACTONASE ACTIVITY
Journal of Biological Systems, 2008A quantitative structure-activity relationship (QSAR) study was performed to model the lactonolysis activity of N-acyl-homoserine lactone lactonase. A data set comprising of 20 homoserine lactones and related compounds was taken from the work of Wang et al. Quantum chemical descriptors were calculated using the semiempirical AM1 method.
Nantasenamat, Chanin +5 more
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Selective transamidation of 3-oxo-N-acyl homoserine lactones by hydrazine derivatives
Org. Biomol. Chem., 2014Hydrazine derivatives are employed for selective amide cleavage of 3-oxo- N -acyl homoserine lactones under physiologically relevant conditions.
Michael A, Bertucci +2 more
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Synthetic Agents for the Derivatization of N-Acyl Homoserine Lactones
2014Quorum sensing is a process of chemical communication in bacteria that enables bacteria to coordinate group function, including unified gene expression. As the quorum sensing mechanism is in part responsible for the virulent activity of many bacteria, inhibiting the communication pathway has the potential to lead to the development of novel antibiotics.
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Inactivation of bacterial quorum sensing signals N-acyl homoserine lactones is widespread in yeasts
Fungal Biology, 2018The inactivation of quorum sensing signals, a phenomenon known as quorum quenching, has been described in diverse microorganisms, though it remains almost unexplored in yeasts. Beyond the well-known properties of these microorganisms for the industry or as eukaryotic models, the role of yeasts in soil or in the inner tissues of a plant is largely ...
Ana Carolina del V. Leguina +6 more
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Trends in Biotechnology, 1997
N-acyl homoserine lactones are bacterial signalling molecules involved in regulating diverse metabolic functions, particularly those relating to virulence, in concert with cell density. Each aspect of the signalling pathway, from production and recognition of the signal to expression of the target genes, offers a potential opportunity for exploitation.
N D, Robson +4 more
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N-acyl homoserine lactones are bacterial signalling molecules involved in regulating diverse metabolic functions, particularly those relating to virulence, in concert with cell density. Each aspect of the signalling pathway, from production and recognition of the signal to expression of the target genes, offers a potential opportunity for exploitation.
N D, Robson +4 more
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Journal of Chemical Ecology, 2012
Many environmental and interactive important traits of bacteria, such as antibiotic, siderophore or exoenzyme (like cellulose, pectinase) production, virulence factors of pathogens, as well as symbiotic interactions, are regulated in a population density-dependent manner by using small signaling molecules.
Anton, Hartmann, Adam, Schikora
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Many environmental and interactive important traits of bacteria, such as antibiotic, siderophore or exoenzyme (like cellulose, pectinase) production, virulence factors of pathogens, as well as symbiotic interactions, are regulated in a population density-dependent manner by using small signaling molecules.
Anton, Hartmann, Adam, Schikora
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n → π* Interactions in N-Acyl Homoserine Lactone Derivatives and Their Effects on Hydrolysis Rates
The Journal of Physical Chemistry A, 2019N-Acyl homoserine lactones (AHLs) mediate population-wide behavioral changes in Gram-negative bacteria through quorum sensing (QS), a process shown to regulate virulence, biofilm formation, and other phenotypes that impact human health. AHLs have been proposed to contain an n → π* interaction that reduces the molecules' susceptibility to signal ...
Daniel J. Schmucker +3 more
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Candidates of quorum sensing bacteria in activated sludge associated with N-acyl homoserine lactones
Chemosphere, 2019This study aimed to explore candidates of microbial groups which is associated with quorum sensing in activated sludge. Activated sludge samples were collected from three wastewater treatment plants (WWTP) to analyze N-acyl homoserine lactone (AHL) by Fourier-transform mass spectrometry (FTMS) and 16S rRNA-based microbial community.
Smarch Panchavinin +4 more
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