Results 181 to 190 of about 12,623 (216)
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Solution structural features of N -acyl homoserine lactones
Tetrahedron Letters, 2015Here we demonstrate that in interbacterial quorum signal moderators, N-acylhomoserine lactones (AHLs), the stabilization of bioactive pharmacophore lactone against lysis is through the e(-) withdrawing N-acyl motif which reduces lactone carbonyl polarization. This lysis is assisted by weak (
Tumminakatti, Shama +4 more
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Imaging N-Acyl Homoserine Lactone Quorum Sensing In Vivo
2010In order to study N-acyl homoserine lactone (AHL)-based quorum sensing in vivo, we present a protocol using an Escherichia coli strain equipped with a luxR-based monitor system, which in the presence of exogenous AHL molecules expresses a green fluorescent protein (GFP).
Hultqvist, Louise Dahl +4 more
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Development and characterization of rat monoclonal antibodies for N-acylated homoserine lactones
Analytical and Bioanalytical Chemistry, 2010Quorum sensing (QS) is a communication mechanism between bacteria using diffusible chemical signaling molecules, which are called autoinducers (AI). By detecting the concentration of quorum sensing molecules through binding to a specific receptor protein, bacteria regulate their gene expressions when the concentration of autoinducers and thus the cell ...
Xiao, Chen +8 more
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QSAR MODEL OF THE QUORUM-QUENCHING N-ACYL-HOMOSERINE LACTONE LACTONASE ACTIVITY
Journal of Biological Systems, 2008A quantitative structure-activity relationship (QSAR) study was performed to model the lactonolysis activity of N-acyl-homoserine lactone lactonase. A data set comprising of 20 homoserine lactones and related compounds was taken from the work of Wang et al. Quantum chemical descriptors were calculated using the semiempirical AM1 method.
Nantasenamat, Chanin +5 more
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Selective transamidation of 3-oxo-N-acyl homoserine lactones by hydrazine derivatives
Org. Biomol. Chem., 2014Hydrazine derivatives are employed for selective amide cleavage of 3-oxo-N-acyl homoserine lactones under physiologically relevant conditions.
Michael A, Bertucci +2 more
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Trends in Biotechnology, 1997
N-acyl homoserine lactones are bacterial signalling molecules involved in regulating diverse metabolic functions, particularly those relating to virulence, in concert with cell density. Each aspect of the signalling pathway, from production and recognition of the signal to expression of the target genes, offers a potential opportunity for exploitation.
N D, Robson +4 more
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N-acyl homoserine lactones are bacterial signalling molecules involved in regulating diverse metabolic functions, particularly those relating to virulence, in concert with cell density. Each aspect of the signalling pathway, from production and recognition of the signal to expression of the target genes, offers a potential opportunity for exploitation.
N D, Robson +4 more
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Detection of bacterial quorum sensing N-acyl homoserine lactones in clinical samples
Analytical and Bioanalytical Chemistry, 2008Bacteria communicate among themselves using certain chemical signaling molecules. These signaling molecules generally are N-acyl homoserine lactones (AHLs) in Gram-negative bacteria and oligopeptides in Gram-positive bacteria. In addition, both Gram-positive and Gram-negative bacteria produce a family of signaling molecules known as autoinducer-2 that ...
Anjali, Kumari +2 more
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A chemosensor to recognize N-acyl homoserine lactone in bacterial biofilm
Sensors and Actuators B: Chemical, 2018Abstract A simple, sensitive, and rapid assay has been developed for detection of N-acyl homoserine lactone (HSL) autoinducers involved in bacterial quorum sensing (QS) by a new coumarin appended rhodamine derivative (RNC) ensembled with Cu2+. RNC-Cu2+ conjugate shows “turn on” fluorescence while binding with HSLs.
Sujoy Das +4 more
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N-Acyl-homoserine lactones and autoinducer-2-mediated quorum sensing during wastewater treatment
Applied Microbiology and Biotechnology, 2017Bacteria can coordinate and synchronize activities through a cell density-dependent regulatory mechanism called quorum sensing (QS). Bacteria can measure their population by the synthesis, secretion, and perception of QS signal molecules to regulate specific gene expression when the population reaches a critical threshold.
Han, Chen +6 more
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Synthetic Agents for the Derivatization of N-Acyl Homoserine Lactones
2014Quorum sensing is a process of chemical communication in bacteria that enables bacteria to coordinate group function, including unified gene expression. As the quorum sensing mechanism is in part responsible for the virulent activity of many bacteria, inhibiting the communication pathway has the potential to lead to the development of novel antibiotics.
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