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Bacterial N-acyl-homoserine-lactone-dependent signalling and its potential biotechnological applications

Trends in Biotechnology, 1997
N-acyl homoserine lactones are bacterial signalling molecules involved in regulating diverse metabolic functions, particularly those relating to virulence, in concert with cell density. Each aspect of the signalling pathway, from production and recognition of the signal to expression of the target genes, offers a potential opportunity for exploitation.
N D, Robson   +4 more
openaire   +2 more sources

Detection of bacterial quorum sensing N-acyl homoserine lactones in clinical samples

Analytical and Bioanalytical Chemistry, 2008
Bacteria communicate among themselves using certain chemical signaling molecules. These signaling molecules generally are N-acyl homoserine lactones (AHLs) in Gram-negative bacteria and oligopeptides in Gram-positive bacteria. In addition, both Gram-positive and Gram-negative bacteria produce a family of signaling molecules known as autoinducer-2 that ...
Anjali, Kumari   +2 more
openaire   +2 more sources

A chemosensor to recognize N-acyl homoserine lactone in bacterial biofilm

Sensors and Actuators B: Chemical, 2018
Abstract A simple, sensitive, and rapid assay has been developed for detection of N-acyl homoserine lactone (HSL) autoinducers involved in bacterial quorum sensing (QS) by a new coumarin appended rhodamine derivative (RNC) ensembled with Cu2+. RNC-Cu2+ conjugate shows “turn on” fluorescence while binding with HSLs.
Sujoy Das   +4 more
openaire   +1 more source

N-Acyl-homoserine lactones and autoinducer-2-mediated quorum sensing during wastewater treatment

Applied Microbiology and Biotechnology, 2017
Bacteria can coordinate and synchronize activities through a cell density-dependent regulatory mechanism called quorum sensing (QS). Bacteria can measure their population by the synthesis, secretion, and perception of QS signal molecules to regulate specific gene expression when the population reaches a critical threshold.
Han, Chen   +6 more
openaire   +2 more sources

Synthetic Agents for the Derivatization of N-Acyl Homoserine Lactones

2014
Quorum sensing is a process of chemical communication in bacteria that enables bacteria to coordinate group function, including unified gene expression. As the quorum sensing mechanism is in part responsible for the virulent activity of many bacteria, inhibiting the communication pathway has the potential to lead to the development of novel antibiotics.
openaire   +1 more source

Gram-negative bacterial communication by N-acyl homoserine lactones: a universal language?

Trends in Microbiology, 1994
The ability of bacterial cells to use small signalling molecules to monitor population growth may help them to react rapidly to environmental change. Regulatory systems made up of a small sensor molecule, an N-acyl homoserine lactone and a protein effector have been identified recently in a wide range of Gram-negative bacteria.
S, Swift, N J, Bainton, M K, Winson
openaire   +2 more sources

High-Performance Liquid Chromatography Analysis of N-Acyl Homoserine Lactone Hydrolysis by Paraoxonases

2010
Mammalian paraoxonases (PONs) are a unique, highly conserved family of calcium-dependent esterases consisting of PON1, PON2, and PON3. The PONs can hydrolyze the lactone ring of a range of N-acyl-L: -homoserine lactone (AHL) quorum sensing signaling molecules, rendering them inactive.
John F, Teiber, Dragomir I, Draganov
openaire   +2 more sources

Quorum-sensing molecules N-acyl homoserine lactones inhibit Trueperella pyogenes infection in mouse model

Veterinary Microbiology, 2018
Trueperella pyogenes is a gram-positive opportunistic pathogen normally causes mastitis, liver abscesses and pneumonia of economically important livestock. It has been suggested that gram-negative bacteria can suppress the growth and virulence of T.
Ting, Huang   +6 more
openaire   +2 more sources

The role of N-acyl homoserine lactones in maintaining the stability of aerobic granules

Bioresource Technology, 2014
In this study, porcine kidney acylase, as N-acyl homoserine lactones (AHLs)-degradation enzyme, was employed for the first time to directly investigate the role of AHLs in the structure stability of aerobic granules. Results clearly showed that inactivation of AHLs by AHLs-acylase could weaken the stability of aerobic granule.
Yaochen, Li   +5 more
openaire   +2 more sources

Inactivation of bacterial quorum sensing signals N-acyl homoserine lactones is widespread in yeasts

Fungal Biology, 2018
The inactivation of quorum sensing signals, a phenomenon known as quorum quenching, has been described in diverse microorganisms, though it remains almost unexplored in yeasts. Beyond the well-known properties of these microorganisms for the industry or as eukaryotic models, the role of yeasts in soil or in the inner tissues of a plant is largely ...
Ana Carolina del V. Leguina   +6 more
openaire   +2 more sources

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