Results 51 to 60 of about 3,877,766 (328)

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

The Lie-Poisson structure of the reduced n-body problem

open access: yes, 2012
The classical n-body problem in d-dimensional space is invariant under the Galilean symmetry group. We reduce by this symmetry group using the method of polynomial invariants.
Albouy A   +7 more
core   +2 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

The reduction on the linear stability of elliptic Euler-Moulton solutions of the n-body problem to those of 3-body problems

open access: yes, 2016
In this paper, we consider the elliptic collinear solutions of the classical $n$-body problem, where the $n$ bodies always stay on a straight line, and each of them moves on its own elliptic orbit with the same eccentricity.
Long, Yiming, Zhou, Qinglong
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Supersymmetric extension of qKZ-Ruijsenaars correspondence

open access: yesNuclear Physics B, 2019
We describe the correspondence of the Matsuo–Cherednik type between the quantum n-body Ruijsenaars–Schneider model and the quantum Knizhnik–Zamolodchikov equations related to supergroup GL(N|M).
A. Grekov, A. Zabrodin, A. Zotov
doaj   +1 more source

The quantum marginal problem for symmetric states: applications to variational optimization, nonlocality and self-testing

open access: yesNew Journal of Physics, 2021
In this paper, we present a method to solve the quantum marginal problem for symmetric d -level systems. The method is built upon an efficient semi-definite program that uses the compatibility conditions of an m -body reduced density with a global n ...
Albert Aloy, Matteo Fadel, Jordi Tura
doaj   +1 more source

A Quasi-Exactly Solvable N-Body Problem with the sl(N+1) Algebraic Structure

open access: yes, 1998
Starting from a one-particle quasi-exactly solvable system, which is characterized by an intrinsic sl(2) algebraic structure and the energy-reflection symmetry, we construct a daughter N-body Hamiltonian presenting a deformation of the Calogero model ...
M. SHIFMAN, Ushveridze A., XINRUI HOU
core   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

open access: yesFEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini   +2 more
wiley   +1 more source

Mathematical modeling of some single-pulse space car flights

open access: yesИзвестия Томского политехнического университета: Промышленная кибернетика, 2023
This paper examines the movement of a spacecraft launching from the surface of the Earth at different speeds, within the framework of the five-body problem “Sun–Earth–Moon–Mars–a body with negligible mass” with a close approach to the surface of the Moon,
Nikita Yu. Isachenkov
doaj   +1 more source

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