Results 221 to 230 of about 151,394 (263)

N-cadherin at the glial scar in the rat

Brain Research, 1999
Following injury to the central nervous system (CNS), astrocytes become reactive and in many cases form a glial scar. Very little is known about the adhesive interactions between astrocytes at the glial scar, even though reactive gliosis and scar formation are a central issue in CNS wound healing.
F, Vázquez-Chona, E E, Geisert
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Identification of a novel N-cadherin antagonist

Peptides, 2008
The cell adhesion molecule, N-cadherin plays a pivotal role in many biological and disease processes. Drugs that modulate N-cadherin function should therefore be useful therapeutic agents. We have used phage display technology to identify amino acid sequences capable of binding to N-cadherin.
Emmanuelle, Devemy, Orest W, Blaschuk
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N-cadherin as a therapeutic target in cancer

Expert Opinion on Investigational Drugs, 2007
During tumor progression, cancer cells undergo dramatic changes in the expression profile of adhesion molecules resulting in detachment from original tissue and acquisition of a highly motile and invasive phenotype. A hallmark of this change, also referred to as the epithelial-mesenchymal transition, is the loss of E- (epithelial) cadherin and the de ...
Agnese, Mariotti, Antonella, Perotti, Cristiana, Sessa, Curzio, Rüegg   +3 more
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N-cadherin in adult rat cardiomyocytes in culture. I. Functional role of N-cadherin and impairment of cell-cell contact by a truncated N-cadherin mutant

Journal of Cell Science, 1996
ABSTRACT N-cadherin is a transmembrane Ca2+-dependent glycoprotein that is part of adherens junctions. It functions with the cell adhesion N-terminal extracellular domain as a site of homophilic cell-cell contacts. The intracellular C-terminal domain provides via a catenin complex the interaction with the cytoskeleton ...
C M, Hertig, M, Eppenberger-Eberhardt, S, Koch, H M, Eppenberger   +3 more
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Role of N‐cadherin in bone formation

Journal of Cellular Physiology, 2002
AbstractCell–cell adhesion mediated by cadherins is essential for the function of bone forming cells during osteogenesis. Here, the evidence that N‐cadherin is an important regulator of osteoblast differentiation and osteogenesis is reviewed. Osteoblasts express a limited number of cadherins, including the classic N‐cadherin.
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Discovery and development of N-cadherin antagonists

Cell and Tissue Research, 2012
This article describes over 20 years of research on antagonists of the cell adhesion molecule, N-cadherin. Four types of antagonists are discussed: synthetic linear peptides, synthetic cyclic peptides, non-peptidyl peptidomimetics of the disulfide linked cyclic peptide N-Ac-CHAVC-NH(2) and monoclonal antibodies directed against the N-cadherin ...
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Is N-Cadherin Expression Important in Ductal Carcinoma?

Southern Medical Journal, 2008
Neural (N)-cadherin is a calcium-dependent cell adhesion molecule that is associated with invasive tumors in breast cancer, but no association with grade or nodal status has been shown in previous studies. The present study examined the expression of N-cadherin in human breast cancer and assessed its prognostic value in long-term patient follow-up (10 ...
Judy A, King, Lalita A, Shevde, Solomon, Ofori-Acquah, Gareth, Watkins, Wen G, Jiang   +4 more
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N-cadherin-associated proteins in chicken muscle

Differentiation, 1991
The development and functional activity of the heart depends on the regulated interaction of cardiac cells. This is in part mediated by cell-cell adhesion molecules such as N-cadherin. N-cadherin belongs to a family of Ca+(+)-dependent, transmembrane, adhesion glycoproteins that promote cell-cell adhesion by molecular self-association extracellularly ...
M J, Wheelock, K A, Knudsen
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Robo is Abl to block N-Cadherin function

Nature Cell Biology, 2002
The molecular pathways involved in wiring the brain have just begun to be elucidated. Work in this issue of Nature Cell Biology has uncovered inhibitory interactions between two such pathways: Roundabout (Robo) and N-Cadherin. This discovery provides a potential mechanistic understanding of how pathways are used in a coordinated manner to guide axons.
Mark M, Emerson, David, Van Vactor
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The cleavage of N-cadherin is essential for chondrocyte differentiation

Biochemical and Biophysical Research Communications, 2010
The aggregation of chondroprogenitor mesenchymal cells into precartilage condensation represents one of the earliest events in chondrogenesis. N-cadherin is a key cell adhesion molecule implicated in chondrogenic differentiation. Recently, ADAM10-mediated cleavage of N-cadherin has been reported to play an important role in cell adhesion, migration ...
Shigeto, Nakazora, Akihiko, Matsumine, Takahiro, Iino, Masahiro, Hasegawa, Ayae, Kinoshita, Kengo, Uemura, Rui, Niimi, Atsumasa, Uchida, Akihiro, Sudo   +8 more
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