Results 231 to 240 of about 151,394 (263)

N‐cadherin is not essential for limb mesenchymal chondrogenesis

Developmental Dynamics, 2004
AbstractThe cell adhesion molecule N‐cadherin is implicated in many morphogenetic processes, including mesenchyme condensation during limb development. To further understand N‐cadherin function, we characterized a new N‐cadherin allele containing the lacZ reporter gene under the regulation of the mouse N‐cadherin promoter.
Yang, Luo, Igor, Kostetskii, Glenn L, Radice   +2 more
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A possible role of N-cadherin in thalidomide teratogenicity

Life Sciences, 2000
Several experimental findings indicate that the adhesion molecule N-cadherin participates in distinct processes of embryogenesis that spatiotemporarily correlate with high sensitivity to thalidomide. Therefore, we suppose that thalidomide might interfere with N-cadherin-mediated interactions.
A, Thiele, M, Thormann, H J, Hofmann, W W, Naumann, K, Eger, S, Hauschildt   +5 more
openaire   +2 more sources

N-Cadherin—a Potential Target for Psychopharmacology

Neurochemical Journal
Glycoprotein N-cadherin (Neuronal cadherin) belongs to the family of calcium-dependent cell adhesion molecules, representing a key element that carries out intercellular contacts in brain neurons. However, it is involved not only in the mechanical connection of neurons, but also influences the specifics of the further development and functional state ...
Y. Y. Firstova, G. I. Kovalev
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N-cadherin expression and function in cultured oligodendrocytes

Developmental Brain Research, 1996
N-Cadherin is a major cell adhesion molecule that is expressed in the developing nervous system where it has been implicated in neural migration and axon growth. Recently, a role for N-cadherin in oligodendrocyte differentiation has been identified [23]. Oligodendrocyte precursors adhere to N-cadherin and mature rapidly to produce myelin sheets.
H R, Payne, J J, Hemperly, V, Lemmon
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Traction forces exerted through N‐cadherin contacts

Biology of the Cell, 2006
Background information. Mechanical forces play an important role in the organization, growth and function of living tissues. The ability of cells to transduce mechanical signals is governed by two types of microscale structures: focal adhesions, which link cells to the extracellular matrix, and adherens junctions, which link adjacent cells through ...
Ganz, Arthur, Lambert, Mireille, Saez, Alexandre, Silberzan, Pascal, Buguin, Axel, Mège, René-Marc, Ladoux, Benoît   +6 more
openaire   +4 more sources

N-cadherin of the human lens.

Current eye research, 1989
N-cadherin was identified in the human lens by its immunological specificity, and concanavalin-A (Con-A) binding. The 135 kd glycoprotein was partially purified from human lens plasma membranes by Con-A affinity column chromatography. In the newborn lens, N-cadherin is distributed equally in amount between cortical and nuclear membranes. It is markedly
P L, Atreya, J, Barnes, M, Katar, J, Alcala, H, Maisel   +4 more
openaire   +1 more source

The N-Cadherin/Catenin Complex in Colon Fibroblasts and Myofibroblasts

Cell Adhesion and Communication, 1999
Fibroblasts and myofibroblasts were isolated respectively from normal colon mucosa and from colon cancers. Immunostaining with an antibody against alpha-smooth muscle actin (alpha-SMA) of the tissues of origin and of early passage cultures showed equal proportions of alpha-SMA positive myofibroblasts in vivo as in vitro.
van Hoorde, Leen, Braet, Katleen, Mareel, Marc   +2 more
openaire   +4 more sources

Stimulation of N-cadherin-dependent neurite outgrowth by small molecule peptide mimetic agonists of the N-cadherin HAV motif

Peptides, 2010
N-cadherin is a cell adhesion molecule that promotes axon outgrowth and synapse formation during the development of the central nervous system. In addition, N-cadherin promotes glial cell adhesion and myelination of axons. Therefore, stimulating N-cadherin function with N-cadherin agonists could be used therapeutically to promote regeneration of the ...
Susan M, Burden-Gulley, Theresa J, Gates, Sonya E L, Craig, Mukur, Gupta, Susann M, Brady-Kalnay   +4 more
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An immobilized antibody targeting N-cadherin facilitates spread of N-cadherin-positive tumour cells.

Anticancer research, 2013
We investigated whether an antibody targeting N-cadherin facilitates the adhesion and spreading of N-cadherin-positive tumour cells under static conditions.Two human melanoma cell lines, HMB-2 and BLM, were selected for their presence and lack of expression of N-cadherin, respectively.
Danielle, Maes, Marc, Bracke, Piet, Ost
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N-cadherin-mediated aggregate formation; cell detachment by Trypsin-EDTA loses N-cadherin and delays aggregate formation

Biochemical and Biophysical Research Communications, 2019
Although cell aggregates/spheroids are useful tools in various fields of cell biology, the mechanism for aggregate formation is not fully resolved yet. Here I show the involvement of N-cadherin in the quick formation of packed aggregates in suspension culture.
openaire   +2 more sources