Results 141 to 150 of about 13,464,291 (195)
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Metabolic Engineering, 2023
N,N-dimethyltryptamine (DMT), 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) and 5-hydroxy-N,N-dimethyltryptamine (bufotenine) are psychedelic tryptamines found naturally in both plants and animals and have shown clinical potential to help treat mental disorders, such as anxiety and depression.
Lucas M. Friedberg +6 more
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N,N-dimethyltryptamine (DMT), 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) and 5-hydroxy-N,N-dimethyltryptamine (bufotenine) are psychedelic tryptamines found naturally in both plants and animals and have shown clinical potential to help treat mental disorders, such as anxiety and depression.
Lucas M. Friedberg +6 more
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Comparison of a placebo, N-dimethyltryptamine, and 6-hydroxy-N-dimethyltryptamine in man
Psychopharmacologia, 19631. Five human subjects received intramuscularly at weekly intervals a placebo and equal doses of 6-hydroxy-N-dimethyltryptamine (6-HDMT) and N-dimethyltryptamine (DMT) (1 mg/kg, 4 subjects; 0.75 mg/kg, 1 subject). 2. DMT produced markedly significant mental effects including anxiety, hallucinations, and perceptual distortions and ...
D E, ROSENBERG, H, ISBELL, E J, MINER
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In vivo metabolism of 5-methoxy-N, N-dimethyltryptamine and N,N-dimethyltryptamine in the rat
Biochemical Pharmacology, 1987Following intraperitoneal administration, 5-methoxy-N,N-dimethyltryptamine and N,N-dimethyltryptamine are subject to both a very rapid uptake into, and clearance from, all tissues examined. The current studies in vivo confirm previous in vitro observations that the routes involved in the metabolism of these compounds include oxidative deamination, N ...
B R, Sitaram +4 more
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N,N-Dimethyltryptamine–Induced Psychosis
Clinical Neuropharmacology, 2015N,N-dimethyltryptamine (DMT) is a 5-hydroxytryptamine 2A and 1A receptor agonist that exhibits potent psychoactive properties in humans. Recreational use of this drug has increased precipitously and is likely to result in an increase in patients presenting with substance-induced psychoses. The present case provides an early example of substance-induced
Neil E, Paterson +2 more
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Pharmacology Biochemistry and Behavior, 1978
Rats were tested for shock elicited fighting under various doses of N,N-dimethyltryptamine (0.12, 0.25, 0.50, 1.0, 4.0, 8.0 mg/kg) and 5-methoxy-N,N-dimethyltryptamine (0.06, 0.12, 0.5, 2.0 mg/kg). Both drugs produced an inhibition of fighting at higher doses but no significant effects at lower doses.
M H Sheard, Michael H Sheard
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Rats were tested for shock elicited fighting under various doses of N,N-dimethyltryptamine (0.12, 0.25, 0.50, 1.0, 4.0, 8.0 mg/kg) and 5-methoxy-N,N-dimethyltryptamine (0.06, 0.12, 0.5, 2.0 mg/kg). Both drugs produced an inhibition of fighting at higher doses but no significant effects at lower doses.
M H Sheard, Michael H Sheard
exaly +3 more sources
A new metabolic pathway for N,N-dimethyltryptamine
Biological Psychiatry, 1986N,N-Dimethyltryptamine (DMT) undergoes a major structural alteration when added to whole human blood or its red blood cells in vitro. A new high-pressure liquid chromatography (HPLC) peak is present in extracts of these treated tissues. The compound responsible for this peak has been identified by ultraviolet spectrophotometry and by mass spectrometry ...
L M, Hryhorczuk +3 more
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N,N-Dimethyltryptamine: An Endogenous Hallucinogen
1981Publisher Summary This chapter reviews the biosynthesis, metabolism, pharmacology, and properties of N,N-dimethyltryptamine (DMT), leading to a conclusion that DMT may be a neurotransmitter in the mammalian brain. The identification of DMT and other hallucinogens in man explains the experience of hallucinatory phenomena in general.
S A, Barker, J A, Monti, S T, Christian
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Hydroxylation and N-demethylation of N,N-dimethyltryptamine
Experientia, 1959Der intermediare Stoffwechsel des psychotropen N,N-Dimethyltryptamins wurde untersucht. N-Methyltryptamin, als Produkt der Demethylierung, und 6-Hydroxy-N,N-Dimethyltryptamin, als Produkt der Hydroxylierung, wurden nachgewiesen und papierchromatographisch charakterisiert.
S, SZARA, J, AXELROD
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Neuromodulatory mechanisms of N,N-dimethyltryptamine
Brain Network and Modulation, 2023N,N-dimethyltryptamine (DMT) is the simplest psychedelic tryptamine and is produced naturally by many plant and animal species, including humans. While classical psychedelics, such as lysergic acid diethylamide, or psilocybin, are gaining interest because of their therapeutic potential, DMT has yet to be fully investigated ...
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Human psychopharmacology of N,N-dimethyltryptamine
Behavioural Brain Research, 1995We generated dose-response data for the endogenous and ultra-short-acting hallucinogen, N,N-dimethyltryptamine (DMT), in a cohort of experienced hallucinogen users, measuring multiple biological and psychological outcome measures. Subjective responses were quantified with a new rating scale, the HRS, which provided better resolution of dose effects ...
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