Results 61 to 70 of about 13,352,036 (198)

Arenavirus Glycan Shield Promotes Neutralizing Antibody Evasion and Protracted Infection

PLoS Pathogens, 2015
Arenaviruses such as Lassa virus (LASV) can cause severe hemorrhagic fever in humans. As a major impediment to vaccine development, delayed and weak neutralizing antibody (nAb) responses represent a unifying characteristic of both natural infection and ...
R. Sommerstein, Lukas Flatz, M. Remy, P. Malinge, G. Magistrelli, N. Fischer, M. Sahin, A. Bergthaler, S. Igonet, J. T. ter Meulen, Dorothée Rigo, P. Meda, N. Rabah, B. Coutard, T. Bowden, P. Lambert, C. Siegrist, D. Pinschewer   +17 more
semanticscholar   +1 more source

Associations between genetically predicted plasma N-glycans and pancreatic cancer risk

All Life, 2023
Objectives: Previous studies have suggested a potential link between glycan levels and pancreatic cancer. To better characterize this relationship, we performed a study to evaluate the association between genetically predicted N-glycan levels in plasma ...
Duo Liu, Tianying Zhao, Jingjing Zhu, Sodbo Sharapov, Evgeny Tiys, Lang Wu   +5 more
doaj   +1 more source

Exploring site-specific N-glycosylation microheterogeneity of haptoglobin using glycopeptide CID tandem mass spectra and glycan database search.

Journal of Proteome Research, 2013
Glycosylation is a common protein modification with a significant role in many vital cellular processes and human diseases, making the characterization of protein-attached glycan structures important for understanding cell biology and disease processes ...
K. Chandler, P. Pompach, R. Goldman, N. Edwards   +3 more
semanticscholar   +1 more source

Simultaneous Glycan-Peptide Characterization Using Hydrophilic Interaction Chromatography and Parallel Fragmentation by CID, Higher Energy Collisional Dissociation, and Electron Transfer Dissociation MS Applied to the N-Linked Glycoproteome of Campylobacter jejuni*

Molecular & Cellular Proteomics, 2010
Campylobacter jejuni is a gastrointestinal pathogen that is able to modify membrane and periplasmic proteins by the N-linked addition of a 7-residue glycan at the strict attachment motif (D/E)XNX(S/T).
Nichollas E. Scott, B. Parker, Angela M. Connolly, Jana Paulech, A. Edwards, B. Crossett, L. Falconer, D. Kolarich, S. Djordjevic, P. Højrup, N. Packer, M. Larsen, S. Cordwell   +12 more
semanticscholar   +1 more source

Mass spectrometric profiling reveals association of -glycan patterns with epithelial ovarian cancer progression

Tumor Biology, 2017
Aberrant changes of N -glycan modifications on proteins have been linked to various diseases including different cancers, suggesting possible avenue for exploring their etiologies based on N -glycomic analysis.
Huanhuan Chen, Zaian Deng, Chuncui Huang, Hongmei Wu, Xia Zhao, Yan Li   +5 more
doaj   +1 more source

Glycan modification of glioblastoma-derived extracellular vesicles enhances receptor-mediated targeting of dendritic cells

Journal of Extracellular Vesicles, 2019
Glioblastoma is the most prevalent and aggressive primary brain tumour for which total tumour lysate-pulsed dendritic cell vaccination is currently under clinical evaluation.
S. Dusoswa, Sophie K. Horrevorts, M. Ambrosini, H. Kalay, N. Paauw, R. Nieuwland, M. Pegtel, T. Würdinger, Y. van Kooyk, J. Garcia-Vallejo   +9 more
semanticscholar   +1 more source

Identification of Glycan Structure Alterations on Cell Membrane Proteins in Desoxyepothilone B Resistant Leukemia Cells*

Molecular & Cellular Proteomics, 2011
Resistance to tubulin-binding agents used in cancer is often multifactorial and can include changes in drug accumulation and modified expression of tubulin isotypes.
M. Nakano, Rohit G. Saldanha, Anja Göbel, M. Kavallaris, N. Packer   +4 more
semanticscholar   +1 more source

Modeling human congenital disorder of glycosylation type IIa in the mouse: conservation of asparagine-linked glycan-dependent functions in mammalian physiology and insights into disease pathogenesis.

Glycobiology, 2001
The congenital disorders of glycosylation (CDGs) are recent additions to the repertoire of inherited human genetic diseases. Frequency of CDGs is unknown since most cases are believed to be misdiagnosed or unrecognized.
Yan Wang, Jenny Tan, M. Sutton‐Smith, David Ditto, M. Panico, Robert M. Campbell, N. Varki, Jeffrey M. Long, J. Jaeken, S. Levinson, A. Wynshaw-Boris, H. Morris, D. Le, A. Dell, H. Schachter, J. Marth   +15 more
semanticscholar   +1 more source

Glycan-dependent and -independent Association of Vesicular Stomatitis Virus G Protein with Calnexin*

Journal of Biological Chemistry, 1996
Calnexin (CNX) is a membrane-bound molecular chaperone that associates with newly synthesized proteins in the endoplasmic reticulum. Although several studies have indicated that it interacts exclusively with glycoproteins that carry monoglucosylated N ...
Kurt S. Cannon, D. Hebert, A. Helenius
semanticscholar   +1 more source

Analysis of the human cancer glycome identifies a novel group of tumor-associated N-acetylglucosamine glycan antigens.

Cancer Research, 2009
The cell surface is covered by a dense layer of protein- and lipid-linked glycans. Although it has been known that distinct glycan structures are associated with cancer, the whole spectrum of cancer-associated glycans has remained undiscovered.
T. Satomaa, A. Heiskanen, I. Leonardsson, J. Ångström, Anne Olonen, M. Blomqvist, Noora Salovuori, C. Haglund, S. Teneberg, J. Natunen, O. Carpén, J. Saarinen   +11 more
semanticscholar   +1 more source