Results 61 to 70 of about 13,066,219 (329)

Salmonella Degrades the Host Glycocalyx Leading to Altered Infection and Glycan Remodeling

Scientific Reports, 2016
Complex glycans cover the gut epithelial surface to protect the cell from the environment. Invasive pathogens must breach the glycan layer before initiating infection.
Narine Arabyan, Dayoung Park, S. Foutouhi, Allison M. Weis, B. Huang, Cynthia C. Williams, P. Desai, Jigna D. Shah, R. Jeannotte, N. Kong, C. Lebrilla, B. Weimer   +11 more
semanticscholar   +1 more source

Comparison of denaturing agent effects in enzymatic N-glycan release for human plasma N-glycan analysis

Turkish Journal of Chemistry, 2022
Glycosylation is an essential posttranslational modification observed in the living proteome. Glycosylation profiles in glycoproteins can change in commonly observed diseases such as cancer. Identifying these changes is crucial in discovering new biomarkers for the early diagnosis of cancer.
KAYILI, H. Mehmet, SAKHTA, Rokia, SALİH, Bekir   +2 more
openaire   +2 more sources

Identification and comparison of N-glycome profiles from common dietary protein sources

Food Chemistry: X
The N-glycomes of bovine whey, egg white, pea, and soy protein isolates are described here. N-glycans from four protein isolates were analyzed by HILIC high performance liquid chromatography and quadrupole time-of-flight tandem mass spectrometry (HILIC ...
Matthew Bolino, İzzet Avcı, Hacı Mehmet Kayili, Hatice Duman, Bekir Salih, Sercan Karav, Steven A. Frese   +6 more
doaj   +1 more source

Profiling of Glycan Receptors for Minute Virus of Mice in Permissive Cell Lines Towards Understanding the Mechanism of Cell Recognition [PDF]

, 2013
The recognition of sialic acids by two strains of minute virus of mice (MVM), MVMp (prototype) and MVMi (immunosuppressive), is an essential requirement for successful infection.
Agbandje-McKenna, M, Chen, X, Cotmore, S, Cummings, RD, Dell, A, Halder, S, Haslam, SM, Heimburg-Molinaro, J, McKenna, R, North, SJ, Smith, DF, Tattersall, P, Trollope, AJ   +12 more
core   +1 more source

Characterization of VRC01, a potent and broadly neutralizing anti-HIV mAb, produced in transiently and stably transformed tobacco [PDF]

, 2014
The proposed clinical trial in Africa of VRC01, a potent broadly neutralizing antibody (bNAb) capable of neutralizing 91% of known HIV-1 isolates, raises concerns about testing a treatment which will be too expensive to be accessible by the most ...
EMEA, Montefiori D.C., Pabst M., Pegu A., WHO   +4 more
core   +1 more source

Human T cell glycosylation and implications on immune therapy for cancer [PDF]

, 2020
Glycosylation is an important post-translational modification, giving rise to a diverse and abundant repertoire of glycans on the cell surface, collectively known as the glycome.
Callewaert, Nico, De Bousser, Elien, Festjens, Nele, Meuris, Leander   +3 more
core   +1 more source

Specific N-glycans of Hepatocellular Carcinoma Cell Surface and the Abnormal Increase of Core-α-1, 6-fucosylated Triantennary Glycan via N-acetylglucosaminyltransferases-IVa Regulation

Scientific Reports, 2015
Glycosylation alterations of cell surface proteins are often observed during the progression of malignancies. The specific cell surface N-glycans were profiled in hepatocellular carcinoma (HCC) with clinical tissues (88 tumor and adjacent normal tissues)
Huan Nie, Xia Liu, Yubao Zhang, Tingting Li, Chao Zhan, W. Huo, Anshun He, Yuanfei Yao, Yueying Jin, Youpeng Qu, Xue-Long Sun, Y. Li   +11 more
semanticscholar   +1 more source

N-glycans of human amniotic fluid transferrin stimulate progesterone production in human first trimester trophoblast cells in vitro [PDF]

, 2004
Aims: During pregnancy, the placenta produces a variety of steroid hormones and proteins. Several of these substances have been shown to exert immunomodulatory effects.
Briese, V., Friese, K., Gundel, G., Jeschke, U., Mylonas, I., Müller, H., Richter, D.-U., Streu, A., Unverzagt, C.   +8 more
core   +1 more source

Plasma N-glycans in colorectal cancer risk [PDF]

Scientific Reports, 2018
AbstractAberrant glycosylation has been associated with a number of diseases including cancer. Our aim was to elucidate changes in whole plasmaN-glycosylation between colorectal cancer (CRC) cases and controls in one of the largest cohorts of its kind. A set of 633 CRC patients and 478 age and gender matched controls was analysed.
Margaret Doherty, Evropi Theodoratou, Ian Walsh, Barbara Adamczyk, Henning Stöckmann, Felix Agakov, Maria Timofeeva, Irena Trbojević-Akmačić, Frano Vučković, Fergal Duffy, Ciara A. McManus, Susan M. Farrington, Malcolm G. Dunlop, Markus Perola, Gordan Lauc, Harry Campbell, Pauline M. Rudd   +16 more
openaire   +4 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source